University of Arizona

P1.021. Esophageal Reconstruction in an Adult with Failed Colonic Interposition and Recurrent Aspiration

Abstract Topic Benign Disease: Esophageal Surgery Case Submission We present a 23-year-old male with a history of tracheoesophageal fistula repaired in childhood with multiple revisions including a esophagostomy and ultimately a colonic interposition. He continued to have recurre...

P1.020. Real-World Deviations From Standard Adjuvant Immunotherapy After Esophagectomy

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background Adjuvant IO is recommended within 4–16 weeks post-esophagectomy, but delays and interruptions are common in practice. Trials like CheckMate 577 permitted treatment delays of up to 10 weeks. We evalua...

The clinical and molecular spectrum of AGO2-associated Lessel-Kreienkamp neurodevelopmental syndrome

Abstract Background Pathogenic variants in AGO2 ,encoding a central component of the RNA-induced silencing complex (RISC), cause the neurodevelopmental disorder Lessel-Kreienkamp syndrome (LESKRES). The variant spectrum and associated molecular mechanisms underlying phenotypic va...

Social Performance Feedback and Managerial Moral Self-Regulation: The Microfoundations of Corporate Social (Ir)Responsibility

Despite growing interest in the microfoundations of corporate social activities, prior research has not articulated the full chain connecting firm-level conditions to managers' psychological processes (a topdown pathway) and back to firm-level corporate social behavior (a bottom-...

The Star Formation History and Evolution of the Ultra-Diffuse M81 Satellite F8D1

Abstract We present deep Hubble Space Telescope (HST) imaging of one of the nearest ultra-diffuse galaxies (UDGs) outside of the Local Group: F8D1, a satellite of M81 known to be tidally disrupting. UDGs are an enigmatic and diverse population, with evolutionary pathways ranging...

A Bayesian approach to postfire debris-flow probability modeling for southern California, United States

Background Intense rainfall on steep, burned landscapes can initiate postfire debris flows (PFDFs). Watershed-scale estimates of PFDF probability in response to a given rainfall intensity are beneficial for assessing PFDF hazards, including prioritizing areas for hazard mitigatio...

Provider-Identified strategies to address homelessness in Arizona: a summary of strategies, evidence, and impact

Few sources have reviewed the state of the evidence on commonly implemented and emerging strategies to prevent and respond to homelessness in the United States. We conducted focus groups with 58 homeless service providers and administrators across Arizona about strategies used to...

Wavelength Requirements for Life Detection via Reflected Light Spectroscopy of Rocky Exoplanets

Searching for signs of life is a primary goal of the Habitable Worlds Observatory (HWO). However, merely detecting oxygen, methane, or other widely discussed biosignatures is insufficient evidence for a biosphere. In parallel with biosignature detection, exoplanet life detection...

Development of a Tool to Assess Competency in Bronchoscopic Lung Volume Reduction Via Endobronchial Valve Placement

RATIONALE: Bronchoscopic lung volume reduction (BLVR) is an established treatment option for severe emphysema, improving lung function and quality of life. Despite its growing use, there are no standardized, validated tools to assess operator competency in performing BLVR, limiti...

Discovery and Characterization of Inhibitors of Ubiquitin-Like Modifier Activating Enzyme 5 (UBA5): Targeting the UFMylation Pathway in Cancer and Neurodegenerative Diseases

Abstract UBA5 is the E1 enzyme that initiates UFMylation, a ubiquitin-like modification implicated in proteostasis, neurodegeneration, and cancer. Here, we report a chemical biology approach to interrogate UBA5 function through small-molecule inhibition. We developed a robust hig...

Host DNA repair factors empower a mechanism of antiviral nucleoside analog resistance

ABSTRACT How host functions affect resistance to antiviral drugs is poorly understood. Ganciclovir, a chain-terminating nucleoside analog, is a first-line therapy against human cytomegalovirus, a widespread herpesvirus that causes life-threatening disease in immunocompromised ind...

Cryotherapy for Subglottic and Tracheal Stenosis in Patients Without Tracheostomies

BACKGROUND: Cryotherapy is used in the endoscopic treatment of subglottic and tracheal stenosis (SGTS), though comparative data remain limited. METHODS: A retrospective chart review identified 49 patients with benign SGTS treated with standard endoscopic management or cryotherapy...

Ryugu and Bennu preserve primordial isotopic heterogeneity absent from the meteorite record

Ivuna-type (CI) carbonaceous chondrites are commonly used as proxies for the composition of the planet-forming disk because their chemical abundances resemble those of the solar photosphere. However, their isotopic uniformity may reflect pervasive alteration and isotopic averagin...

SynCellNet: generative AI framework for single-cell RNA sequencing data generation and validation

Generative AI plays a pivotal role in addressing the challenges of data scarcity and class imbalance in single-cell transcriptomics. In this work, we present SynCellNet, a generative AI technique for synthesis of single-cell gene expression profiles. SynCellNet can be used to enr...

Electron Shot Noise on a Current Biased Antenna

Abstract The Parker Solar Probe (PSP) Fields Experiment (FIELDS) uses Radio Frequency Spectrometer (RFS) data and Quasi‐Thermal Noise Spectroscopy (QTN) to determine the temperature and density of electrons in the heliosphere. The FIELDS antennas typically operate with a negative...

Breaking voltage-controlled magnetic anisotropy–magnetoresistance trade-off for ultralow-energy switching in magnetic tunnel junctions

Electric-field control of spin states offers a promising route to ultralow-power, ultrafast magnetization switching in spintronic devices such as magnetic tunnel junctions (MTJs). However, enhancing voltage-controlled magnetic anisotropy (VCMA) through interfacial engineering oft...

Does plastic waste present an infection hazard? Current evidence, surveillance challenges and research priorities

Abstract Unmanaged plastic waste is widespread in settings with limited waste collection, yet its contribution to infectious disease risk remains poorly understood. In this review, we synthesise current evidence on the human health implications of plastic waste, with a specific f...

Inventories of Rich Carbon-Chain Chemistry in Prestellar and Starless Cores in the Perseus Molecular Cloud

Abstract Carbon-chain molecules serve as an important reservoir of reactive organic matter that will eventually be incorporated into protoplanetary disks, planets, and cometary material. Prestellar and starless cores are composed of cold (~ 10 K) and dense (~ 105 cm−3) clumps of...

Evaluation of a 3D Crustal Velocity Model for Northern Israel Using Wavefield Simulations

ABSTRACT We evaluate a recently developed 3D crustal velocity model for northern Israel using numerical simulations of seismic wave propagation for eighteen earthquakes (3≤Mw≤4.5). Synthetic seismograms were compared with observed recordings from the Israel Seismic Network in the...

Design of Fluorescent Membrane Scaffold Proteins for Nanodiscs

Abstract Nanodiscs are nanoscale lipid bilayer membrane mimetics surrounded by two membrane scaffold proteins (MSPs). They are widely used as soluble cassettes for membrane proteins and lipids in diverse applications in structural, functional, and biophysical studies. The origina...