University of Alberta

Therapeutic-scale CAR-NK microrobots with programmable swarm navigation for targeted solid tumor therapy

An urgent requirement in chimeric antigen receptor (CAR) immune cell therapy [e.g., CAR–natural killer (NK) cells] for solid tumors is to engineer the cells for precise tumor targeting. Meanwhile, medical microrobots can be navigated toward specific target sites using external ma...

Systematic review of clinical trials and cohort studies evaluating HIV post‐exposure prophylaxis (PEP) regimens to inform updated Canadian guidelines

Abstract Background We conducted a systematic review of clinical trials and cohort studies on HIV post‐exposure prophylaxis (PEP) regimens to inform updated 2025 Canadian guidelines. Methods We searched Medline and Embase (July 2017–June 2024) for studies reporting on: HIV acquis...

Real‐Life Psychological Experiences and Cardiac Autonomic Physiology Among Survivors of a Myocardial Infarction in Midlife

Abstract Middle-aged women with ischemic heart disease have a higher burden of psychosocial factors compared with male counterparts. Data on daily life stress and autonomic physiology could help guide targeted interventions. We studied 302 individuals ≤ 61 years of age (129 women...

Solar-driven photocatalytic air purification for road infrastructure: Pollutant dynamics, material integration, and sustainable engineering

Road infrastructure provides a scalable platform for integrating photocatalytic technologies to mitigate urban air pollution. However, practical deployment remains uncertain because pollutants in road environments show substantial diversity and dynamic variation in their emission...

A standardized permafrost ground temperature collection for Canada 2025

Abstract. Ground temperature is an essential variable for monitoring the thermal state of permafrost, developing models, and conducting fundamental research. However, the usability of GT data in Canada is often hampered by inconsistent file formats, a lack of metadata standardiza...

Seasonal surface melt onset and firn freeze-up across the central Wrangell and St. Elias Mountains

Abstract. High-elevation alpine firn is increasingly influenced by surface melt and meltwater retention, yet the spatial extent and timing of these processes remain poorly quantified. Here we present spatially distributed estimates of seasonal surface melt onset and firn freeze-u...

Convective Amplification of Ionospheric Feedback by a Finite‐Duration Inertial Alfvén‐Wave Source

Abstract We investigate the ionospheric feedback instability (IFI) driven by a finite‐duration localized source of inertial Alfvén waves. Wave‐excited conductance perturbations undergo Pedersen mobility drift in the convection and wave electric fields and are amplified. A causal...

MR Imaging and Radiomics Features for Predicting Variant Histology of Bladder Cancer: A Single Centre Retrospective Analysis

ABSTRACT Introduction Compare MRI features of bladder variant histology (VH) and pure urothelial carcinoma (UC) and determine if MRI radiomics features can predict VH. Methods In this retrospective study, cystectomy pathology database search yielded 37 patients with tumours with...

From orientation to action: how thinking longer at the start matters for successful complex problem-solving efficiency

Process data from complex problem-solving (CPS) tasks have allowed researchers to extensively investigate time- and action-related indicators associated with accuracy. Nevertheless, little research has examined the association between these indicators and response time in success...

Perils of the Paleocene: vertebrate and invertebrate induced bioerosion in freshwater turtles from Tiupampa, Bolivia (early Paleocene)

Abstract Turtles provide an important link between terrestrial and aquatic ecosystems, acting as both predators and prey, while also being an important host for a range of parasites. The dermal armor that characterizes the group ensures their abundance in the vertebrate fossil re...

Photon Absorption Remote Sensing Virtual Histopathology: A Preliminary Exploration of Diagnostic Equivalence to Gold-Standard H&E Staining in Skin Cancer Excisional Biopsies

Background: Photon Absorption Remote Sensing (PARS) enables label-free imaging of subcellular morphology by observing absorption interactions. Coupled with deep-learning, PARS produces label-free virtual hematoxylin and eosin (H&E) images in unprocessed tissues. This study evalua...

Phosphorylated STYK1 Promotes Gemcitabine Resistance via Autophagy‐Mediated Cancer Stemness in Pancreatic Cancer

ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies, with gemcitabine resistance remaining a major clinical challenge. Although cancer stemness and autophagy have both been implicated in PDAC chemoresistance, the mechanism by which their crosst...

Does EQ-5D measure the most relevant aspects of health across cultures? Findings from a multi-country qualitative and card-sorting study

The EQ-5D is a widely used measure of health-related quality of life (HRQoL) in health services and economic evaluations globally. However, its cross-cultural content validity remains underexplored. This study assesses the relevance and adequacy of EQ-5D across diverse cultural c...

mRNA Delivery with Lipopolymers to Rejuvenate TRAIL Therapy for Lung Cancer Treatment

Abstract Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) has long been identified as a promising therapeutic due to its ability to induce apoptosis selectively in cancer cells. However, poor stability and rapid clearance of the administered TRAIL protein in circul...

No effect of short‐term exposure to ocean acidification on individual‐level variation in behaviour and susceptibility to predation in a Great Barrier Reef damselfish

Abstract Ocean acidification, caused by rising carbon dioxide (CO 2 ) in the atmosphere, has been reported to negatively impact a wide variety of behaviours in fishes, including activity, exploration, and predator avoidance. These effects have been documented at the population le...

Co-creating and testing a bibliotherapy e-storybook for children coping with parental complex post-traumatic stress disorder

The e-storybook was perceived as a useful bibliotherapy tool to support child and family outcomes and to facilitate meaningful conversations about family experiences.

Longleaf Pine Drought Resilience is More Sensitive Than Resistance to Competition Reduction but Influenced by Site Conditions

Competition reduction is widely considered an effective strategy for mitigating drought impacts. Yet little is known about the efficacy of this strategy on drought-tolerant species, particularly across contrasting silvicultural treatments. We reconstructed annual growth of longle...

Improving Discharge Instructions: Systematic Review of Language and Health Literacy Interventions.

CONTEXT: Effective pediatric inpatient discharge relies on clear, responsive communication to support safe transitions from hospital to home. Families who use a language other than English and those with lower health literacy experience disproportionate barriers during discharge,...

Recruitment by Exporters: Implications for Labour Demand Concentration and Labour Market Matching

ABSTRACT Leading up to Slovenia's entry into the EU, Slovenian exporters experienced large reductions in tariffs with their main trading partners, the EU member countries. We exploit variation in exports during this period to examine the role of exporting in the firms' recruiting...

Evidence for dromaeosaurid scavenging on Albertosaurus (Dinosauria: Tyrannosauridae)

Abstract Direct evidence of trophic interactions in the fossil record (e.g., feeding traces, stomach contents) are key to understanding predator–prey relationships between extinct species and reconstructing ancient ecosystems. Recently discovered associated cranial material of an...