University Hospital of Bern

Safety and Efficacy of Right‐ Versus Left‐Sided Transvenous Lead Extraction

ABSTRACT Background and Aims Transvenous lead extraction (TLE) is increasingly performed for malfunction or infection of cardiac implantable electronic devices. Because of anatomic differences, TLE for right‐sided (RS) electrodes may differ in outcome. This study aimed to evaluat...

Accelerated TMS is associated with changes of subgenual cingulate–default mode network coupling in depression: an observational 7 Tesla fMRI study

Abstract Background Accelerated transcranial magnetic stimulation (aTMS) is an effective treatment for depression, but its neurobiological mechanisms of action remain to be elucidated. This study used high-resolution 7-Tesla MRI to investigate changes in resting-state functional...

Exploring patients' and family members’ perspectives on intensive care unit experiences through unsolicited feedback: A qualitative content analysis

Background Intensive care unit (ICU) stays are profound and distressing experiences for critically ill patients and their family members, often resulting in physical, psychological, cognitive, and social sequelae. Existing knowledge stems largely from structured interviews or que...

Promotion of long-term health in early life

Noncommunicable chronic diseases (NCDs) are on the rise in high-income countries, leading to substantial morbidity and mortality and contributing to increased resource demands and healthcare costs. Early-life exposures can initiate trajectories that culminate in NCDs later in lif...

Long-term outcomes of balloon dilation of the eustachian tube under local anesthesia

PURPOSE: To evaluate the long-term outcomes, safety, and feasibility of balloon dilation of the Eustachian tube (BDET) performed under local anesthesia in patients with baro-challenge-induced and obstructive Eustachian tube dysfunction (ETD). METHODS: This prospective observation...

Accuracy of CT-derived interarterial and intramural anomalous coronary arteries anatomy compared with 3D-reconstructed IVUS in-vivo reference

In anomalous aortic origin of a coronary artery (AAOCA), coronary CT angiography (CCTA) is the primary tool for anatomical assessment. However, CCTA measurements lack validation against a high-resolution in-vivo standard. To assess CCTA reliability for lumen dimensions and intram...

Variable Expressivity in Long QT Syndrome Type 2 Rabbits Defines a Low Threshold for Therapeutic I Kr Restoration

Long QT syndrome type 2 (LQT2) is caused by pathogenic variants in the hERG potassium channel, resulting in QT prolongation, polymorphic ventricular tachycardia (pVT), and sudden cardiac death. We previously developed a transgenic LQT2 rabbit model that recapitulates the human di...

Reinforced Polyester Patch Augmentation Improves Biomechanical Properties of Thin Fascia Lata Grafts for Superior Capsule Reconstruction

Purpose To investigate the effect of reinforced polyester patch augmentation on the biomechanical characteristics of thin fascia lata graft. Methods Three graft types were made from fascia lata: (1) thin graft; (2) thin graft augmented with a reinforced polyester patch placed bet...

Artificial intelligence for lung disease quantification in systemic sclerosis-associated interstitial lung disease and other connective tissue disease-associated interstitial lung disease

PURPOSE OF REVIEW: Systemic sclerosis-associated interstitial lung disease (SSc-ILD) is the leading cause of disease-related mortality in systemic sclerosis and the connective tissue disease-associated ILD (CTD-ILD) in which artificial intelligence imaging has advanced most rapid...

Oveporexton for Narcolepsy Type 1 — Results from Two Phase 3 Trials

BACKGROUND: Narcolepsy type 1 is characterized by excessive daytime sleepiness, cataplexy, disrupted sleep, sleep paralysis, and hypnagogic or hypnopompic hallucinations. Oveporexton (TAK-861), an oral orexin receptor 2-selective agonist, reduced symptoms of narcolepsy type 1 in...

Rehabilitation and the post-intensive care syndrome across the recovery continuum: a narrative review

Purpose Improved survival from critical illness has produced a growing population of intensive care unit (ICU) survivors with new or worsened physical, cognitive, and mental-health impairment, defined as post-intensive care syndrome (PICS), and frequent distress among families/ca...

Non‐contrast CT Markers of Hematoma Expansion and Andexanet Response in Factor Xa Inhibitor‐Associated Intracerebral Hemorrhage: An Analysis from ANNEXa ‐I Trial

In this post hoc analysis of the ANNEXa-I trial (n = 434), we evaluated non-contrast computed tomography (NCCT) markers of hematoma expansion (HE) in factor Xa inhibitor (FXai) -associated intracerebral hemorrhage (ICH). At least one NCCT marker was present in 72.1%, and HE (≥12....

Cortical layer 6b mediates state-dependent changes in brain activity and effects of orexin on waking and sleep.

One of the most distinctive features of the mammalian cerebral cortex is its laminar structure. Of all cortical layers, layer 6b (L6b) is by far the least studied, despite exhibiting direct sensitivity to orexin and having widespread connectivity, suggesting an important role in...

Predicting SILENT after lithium poisoning: a multicenter cohort study and pragmatic risk stratification model

INTRODUCTION: The Syndrome of Irreversible Lithium-Effectuated Neurotoxicity (SILENT) is a rare but potentially devastating complication of lithium poisoning. Current evidence rests on case reports and small series, leaving its true incidence, risk factors, and follow-up tools po...

Next Generation Sequencing for the Differentiation of Benign and Malignant Biliary Strictures

The differentiation between benign and malignant biliary strictures remains a significant clinical challenge. Recent studies have suggested that next generation sequencing (NGS) can improve the diagnostic accuracy. However, evidence on its performance in routine clinical practice...

Awareness and management of post-bariatric hypoglycemia: an international survey of healthcare professionals

Abstract Postprandial hypoglycemia (PBH) is a recognized complication following bariatric surgery, but real-world data on its management by healthcare professionals (HCPs) is lacking. To address this, a 25-item multilingual questionnaire was developed and distributed online to HC...

Association of admission LDL cholesterol with clinical profile and 3-months outcomes after ischaemic stroke

Abstract Background and aim We investigated whether admission LDL-C levels are associated with clinical profile and outcomes after acute ischaemic stroke by comparing patients stratified into five LDL-C groups. Patients and methods We retrospectively analyzed consecutively includ...

Sleep-stage dynamics predict current sleep-disordered breathing and future cardiovascular risk

ABSTRACT Sleep-disordered breathing (SDB) is a major contributor to cardiovascular morbidity and disrupts both the macrostructure and dynamics of sleep stages (W, N1, N2, N3, REM). While specific alterations in sleep macrostructure, such as reduced durations of N3 and REM, have b...

Session-by-session client feeling and clarification processes over the course of emotion-focused therapy

Background: Emotion-Focused Therapy (EFT) is an effective form of psychotherapy for a range of psychological problems.While earlier research demonstrated the effect of in-session processes as being central for explaining the effects of EFT, it is unclear what the role of client's...

Clinical utility of ultrasound by general practitioners: a systematic review

Abstract Background The clinical use of ultrasound by general practitioners has expanded rapidly, but uncertainty persists in clinical practice regarding which indications can improve diagnostic process and which rather represent low-value care. Methods We conducted a systematic...