University Hospital of Bern

European S2k guidelines for hidradenitis suppurativa/acne inversa Part 1. Epidemiology, diagnosis and clinical assessment

BACKGROUND: This first part of the S2k guidelines is an update of the 2015 S1 European guidelines based on the structured assessment of clinically relevant topics by the panel of experts. It is complemented by Part 2, which deals with treatments. OBJECTIVES: These guidelines aim...

Orthogeriatric Fracture Syndrome: Time Is Mobility!

Bissoto et al [...]

Quantitative MRI Susceptibility: Mapping of Transient Ischemic Attack—A Preliminary Study

A transient ischemic attack (TIA) is a transient episode of neurological dysfunction without evidence of acute infarct demarcation on neuroimaging. The radiographic features of TIAs are uncertain, as since there is currently no perfect imaging method with which to differentiate a...

Intraarterial Thrombolysis: Past, Present, Future

Suboptimal clinical outcomes are common after ischemic stroke with large vessel occlusion despite current reperfusion treatment with intravenous thrombolysis and mechanical thrombectomy. Targeting residual distal arterial and microvascular occlusions with intraarterial thrombolys...

Awake Prone Positioning in Moderate ARDS: A Case Report

Background: Legionella pneumophila is a rare but severe cause of community-acquired pneumonia and can lead to acute respiratory distress syndrome (ARDS). Awake prone positioning (APP) has been recognized as an effective adjunct for non-intubated patients with hypoxemic respirator...

A multi-factor machine learning model for predicting and characterizing clinical trial failures

Abstract Background About 15% of clinical trials terminate prematurely (fail), causing financial losses and delaying treatment development. Methods This study utilized a subset of interventional trial records from the 471,252 studies registered in ClinicalTrials.gov until Novembe...

Current Use, Monitoring and Reversal of Neuromuscular Block in Pediatric Anesthesia and Intensive Care: A Web‐Based Cross‐Sectional ESAIC Survey

BACKGROUND: Neuromuscular blocking agents are recommended by the European Society of Anaesthesiology and Intensive Care (ESAIC) and European Society of Paediatric Anaesthesia (ESPA) for facilitating tracheal intubation in children. Despite these recommendations, real-world data o...

Validation of the AO Spine Osteoporotic Fracture Classification—effect of geographical region on reliability and reproducibility

Regional differences affect the reliability of the AO Spine-DGOU Osteoporotic Fracture Classification. European participants showed the highest agreement. This study underscores the need for addressing regional factors to improve the system’s global clinical utility. To evaluate...

Tumour Volume Independently Predicts Metastasis in ISUP 2 Prostate Cancer

Background and Objectives: The outcomes for patients with localised prostate cancer are variable, even within defined tumour grades or clinical risk groups. Identifying features associated with disease aggression is imperative in contemporary PCa research. ISUP 2 PCa is particula...

Aflibercept 8 mg in neovascular age-related macular degeneration and diabetic macular oedema: Translating clinical trials into clinical practice

Abstract Provide expert-informed guidance on the integration of aflibercept 8 mg into routine clinical care for patients with neovascular age-related macular degeneration (nAMD) and diabetic macular oedema (DMO), based on clinical trial and real-world evidence. Sixteen retina spe...

Using long-axial field-of-view dynamic PET/CT data to generate synthetic contrast enhanced CT images

ABSTRACT Purpose Dynamic whole-body [ 18 F]FDG PET/CT (DWB-PET/CT) imaging performed on long-axial field-of-view (LAFOV) systems enables the simultaneous assessment of tracer delivery and metabolism across extended anatomical regions. We investigated whether tracer delivery infor...

Long-term type 2 diabetes risk prediction using machine learning with childhood, adolescent, and genetic factors

Abstract Late diagnosis of type 2 diabetes increases patient morbidity and healthcare burden, yet current prediction models use adult risk factors to estimate 5–10-year risk. In this manuscript, we evaluate long-term prediction of type 2 diabetes over 38 years using childhood fac...

Policy (dis)integration in water management: a historical analysis of a Swiss case

Abstract Over the past 170 years, water management in Switzerland has undergone a profound transformation. What began as a localized, event-driven practice shaped by immediate needs and local initiative—such as efforts to ensure flood protection—gradually evolved into a complex,...

Neurological paraneoplastic syndromes in patients with breast and gynecological cancer—a case series and structured literature review

Abstract Purpose Neurological paraneoplastic syndromes (PNS) occur in less than 1% of patients with cancer but carry a significant clinical burden. Prognosis strongly depends on timely diagnosis and treatment. This study presents an illustrative case series and a structured revie...

MicroRNAs as Biomarkers for Adenomyosis: A Systematic Review

Background/Objectives: Adenomyosis is a chronic gynecological disorder characterized by the presence of endometrial tissue within the myometrium, causing pelvic pain, abnormal uterine bleeding, and infertility. Despite its high prevalence, the molecular mechanisms underlying dise...

Factors influencing female physicians’ careers in the German-speaking part of Switzerland

Despite an increase in female physicians in Swiss hospitals, most executive positions are still held by male physicians. This study aimed to identify obstacles and institutional factors influencing female physicians' careers and to evaluate ways to support their professional adva...

Effectiveness of Simulation-Based Training for Thoracentesis - A Systematic Review and Meta-Analysis

BACKGROUND: Thoracentesis is a common bedside procedure. Complication rates are, among other factors, associated with the clinicians' skills. Simulation-based training (SBT) for teaching procedural skills is widely recommended in medical education. However, the current evidence o...

Diabetes Mellitus and Long-Distance Running: A Systematic Review

BACKGROUND: Athletes with diabetes increasingly participate in endurance running, benefiting from physiological adaptations and technological advances like continuous glucose monitoring (CGM) for glycemic control. So far, no comprehensive review summarizing the current knowledge...

Empagliflozin in GSD-Ib: Long-term safety and sustained recovery of neutrophil function including NET formation

Glycogen storage disease type Ib (GSD-Ib) engenders neutropenia and severe neutrophil dysfunction, leading to recurrent infections and inflammatory complications. Recent studies have identified intracellular accumulation of 1,5-anhydroglucitol-6-phosphate (1,5-AG6P) as a key mech...

Serum Glial Fibrillary Acidic Protein Dynamics, Disease Progression, and Therapy Response in Multiple Sclerosis

Importance: Capturing individual multiple sclerosis (MS) progression is difficult; few studies have evaluated glial fibrillary acidic protein (GFAP) in large longitudinal cohorts with independent validation. Objective: To investigate whether serum GFAP levels and treatment-relate...