University Hospital of Bern

Aflibercept 8 mg in neovascular age-related macular degeneration and diabetic macular oedema: Translating clinical trials into clinical practice

Abstract Provide expert-informed guidance on the integration of aflibercept 8 mg into routine clinical care for patients with neovascular age-related macular degeneration (nAMD) and diabetic macular oedema (DMO), based on clinical trial and real-world evidence. Sixteen retina spe...

Using long-axial field-of-view dynamic PET/CT data to generate synthetic contrast enhanced CT images

ABSTRACT Purpose Dynamic whole-body [ 18 F]FDG PET/CT (DWB-PET/CT) imaging performed on long-axial field-of-view (LAFOV) systems enables the simultaneous assessment of tracer delivery and metabolism across extended anatomical regions. We investigated whether tracer delivery infor...

Factors influencing female physicians’ careers in the German-speaking part of Switzerland

Despite an increase in female physicians in Swiss hospitals, most executive positions are still held by male physicians. This study aimed to identify obstacles and institutional factors influencing female physicians' careers and to evaluate ways to support their professional adva...

MicroRNAs as Biomarkers for Adenomyosis: A Systematic Review

Background/Objectives: Adenomyosis is a chronic gynecological disorder characterized by the presence of endometrial tissue within the myometrium, causing pelvic pain, abnormal uterine bleeding, and infertility. Despite its high prevalence, the molecular mechanisms underlying dise...

Effectiveness of Simulation-Based Training for Thoracentesis - A Systematic Review and Meta-Analysis

BACKGROUND: Thoracentesis is a common bedside procedure. Complication rates are, among other factors, associated with the clinicians' skills. Simulation-based training (SBT) for teaching procedural skills is widely recommended in medical education. However, the current evidence o...

Serum Glial Fibrillary Acidic Protein Dynamics, Disease Progression, and Therapy Response in Multiple Sclerosis

Importance: Capturing individual multiple sclerosis (MS) progression is difficult; few studies have evaluated glial fibrillary acidic protein (GFAP) in large longitudinal cohorts with independent validation. Objective: To investigate whether serum GFAP levels and treatment-relate...

Diabetes Mellitus and Long-Distance Running: A Systematic Review

BACKGROUND: Athletes with diabetes increasingly participate in endurance running, benefiting from physiological adaptations and technological advances like continuous glucose monitoring (CGM) for glycemic control. So far, no comprehensive review summarizing the current knowledge...

Empagliflozin in GSD-Ib: Long-term safety and sustained recovery of neutrophil function including NET formation

Glycogen storage disease type Ib (GSD-Ib) engenders neutropenia and severe neutrophil dysfunction, leading to recurrent infections and inflammatory complications. Recent studies have identified intracellular accumulation of 1,5-anhydroglucitol-6-phosphate (1,5-AG6P) as a key mech...

Alignment-free convolutional neural network classification of glycemic states in type 1 diabetes from GC–IMS breath spectra

Abstract Reliable detection of glycemic dysregulation, particularly hypoglycemia, is essential for people with diabetes, yet current approaches rely on capillary blood sampling or require subcutaneous sensor insertion. Breath analysis offers a non-invasive alternative by capturin...

A Case Report on Cerebral Autoregulation in Posterior Reversible Encephalopathy Syndrome After Aneurysmal Subarachnoid Hemorrhage

BACKGROUND: Disturbed cerebral autoregulation remains a theoretical contributor to posterior reversible encephalopathy syndrome (PRES), but it has not been captured before. We report invasively measured autoregulation indices in a 50-year-old female with aneurysmal subarachnoid h...