Université Grenoble Alpes

Immobilization of Alginate Microbeads With Whole‐Cells Expressing Nitrilase for Continuous Nicotinic Acid Production in Chip Millireactor

ABSTRACT The biocatalytic production of nicotinic acid using nitrilases has emerged as a promising alternative to conventional chemical synthesis, offering improved selectivity and environmental sustainability. In this study, we developed a continuous‐flow millireactor system emp...

Metric and spectral aspects of random complex divisors

For any integer n\geq 2 , we prove that for any large enough integer d , with large probability the injectivity radius of a random degree d complex hypersurface in \mathbb{C}P^{n} is larger than {d^{-(n+2)/2}} . Here the hypersurface is endowed with the restriction of the ambient...

Laser‐Generated CuPdAgPtAu High‐Entropy Alloy Nanoparticles—Thermal Segregation Threshold and Elemental Segregation

ABSTRACT In this study, noble metal HEA NPs (CuPdAgPtAu) are produced from equimolar and Cu‐ or Ag‐enriched bulk targets via laser ablation in liquids, with structural and compositional analyses by advanced electron microscopy and XRD, complemented by atomistic simulations. Equim...

Decoupling the Role of Nanoparticle Rigidity and Chemistry in Particle Transport through the Brain Parenchyma

Abstract Drug delivery to the brain involves challenging transportation across multiple biological barriers. Despite the great tunability of polymeric nanoparticles, the synthetic challenge of varying the physical property of a nanoparticle without varying its chemical formulatio...

Diffusion and gettering mechanisms of W and Fe in 300 mm silicon substrates

Metallic contamination is a major reliability issue in CMOS image sensor processing, where recombination-active impurities can increase dark current and pixel defects. In this work, the behavior of tungsten and iron is studied in several 300 mm silicon-based stacks under the same...

Serum GFAP and Age Accurately Distinguish AQP4 ‐ IgG Positive and Double Seronegative NMOSD From MOGAD After a Recent Attack

BACKGROUND: Serum neurofilament-light chain (sNfL) and glial fibrillary acidic protein (sGFAP) are associated with multiple sclerosis (MS) activity. This study aimed to identify patient- and disease-level determinants of sNfL and sGFAP and to evaluate their ability to support dif...

Efficacy of a digital mental health program for university students: A randomized controlled trial comparing online and hybrid delivery

University students are a high-risk population for mental health problems. However they often face barriers to care. Digital Mental Health Interventions are scalable tools to support well-being, yet evidence regarding optimal delivery formats remains mixed. This study assessed th...

More is not always better: Dissociative photoionization limits the EUV absorbing photoacid generator pentafluorophenyl triflate in photolithography

Pentafluorophenyl triflate has been explored as a highly absorbing neutral photoacid generator (PAG) candidate for next-generation chemically amplified resists used in extreme ultraviolet (EUV) lithography. Although increased fluorination enhances EUV absorption, this study demon...

On the Cl2 plasma etching mechanisms of AlN micropillars: Carrier wafer impact

Plasma etching of aluminum nitride (AlN) is a critical step in the fabrication of advanced optoelectronic and electronic devices, particularly deep-ultraviolet light-emitting diodes based on nanowire architectures. In research and development, small AlN samples are commonly mount...

Climate mitigation contributes more to population persistence than evolutionary adaptation in a long-lived seabird

Evolutionary rescue–the process by which adaptive evolution prevents population extinction following environmental deterioration –is frequently proposed as a buffer against biodiversity loss under climate change, yet its capacity to alter future population trajectories is rarely...

JuRa: The Juventas Radar on Hera Mission to Probe Internal Structure of Didymos and Dimorphos Asteroids

Abstract JuRa, the Juventas Radar, is the sounding radar of the Hera/ESA mission on cruise to the asteroid Didymos and its moon, Dimorphos. In 2027, it will, for the first time, do direct observation of the internal structure of an asteroid for the benefit of both science and pla...

Orbital and Spin–Orbit Torque Interplay in Ta/W-Based Magnetic Tunnel Junctions with Vertical Nonlocal Switching

Abstract Spin–orbit torque (SOT) enables ultrafast, energy-efficient magnetization switching, making it promising for MRAM cache applications. However, current SOT-MRAM devices face write efficiency limitations, with charge-to-spin conversion (ξDL) reaching only ∼ 45%, well below...

Probabilistic Characterisation of Service Lifetime of Ageing Infrastructures

Abstract Ageing infrastructures are increasingly exposed to deterioration mechanisms related to time, environmental conditions, and increasing operational demands. Ensuring their safety and serviceability therefore requires continuous monitoring and reliable methods to assess the...

Microsecond-pulsed nanocalorimetry: a scalable approach for ultrasensitive heat capacity measurements

Abstract We introduce a nanocalorimetric technique based on microsecond-pulsed heating (µs-PHnC) that enables high-sensitivity, quasi-isothermal heat capacity measurements on nanoscale samples. Such resolution is critical for exploring thermodynamic signatures in low-dimensional...

Mont Blanc ice core: δ15N of Ammonium

Dataset to interpret the δ15N(NH4+) in a Mont Blanc ice core. The document includes high resolution measurements and decadal averages of the CDD16 ice core. High-resolution measurements are in depth (m) or age (a CE). Decadal averages are mass weighted means. The long term values...

On the use of seismic noise studies for landslide rock block hazard assessment

As emphasized by Pazzi et al. 1 , robust constraints on rock-mass volume are essential for landslide hazard assessment. However, such estimates are inherently challenging due to (i) complex geometries, (ii) heterogeneous material properties, and (iii) poorly constrained boundary...

A memory of Paleozoic to Quaternary Greenhouse climates recorded in Southern African regolith

Abstract In this article, we explore the potential of iron-rich duricrust regoliths from old erosional anorogenic surfaces to record clues of the long-term continental paleoclimatic evolution. We coupled geochemical, mineralogical and geochronological analyses on iron oxides and...

Unsupervised deep learning for limited-angle STEM-EDX tomography: application to 3D chemical analysis of phase-change memory devices

Abstract Energy-dispersive X-ray (EDX) tomography in scanning transmission electron microscopy (STEM) enables three-dimensional elemental mapping at the nanoscale. However, its application remains challenging when sample geometry severely restricts the accessible tilt range, and...

Learning-Based Methods and the Future of Numerical Ocean and Sea-Ice Modeling

The field of operational oceanography is undergoing a significant evolution with the increasing integration of artificial intelligence (AI) methods, which are complementing and, in some cases, redefining traditional numerical modeling approaches. This review explores how AI metho...

Coupling Quantum Mechanical Modeling and Molecular Dynamics on Heterogeneous Supercomputers for Studying Distal Mutation Effects on Drug Binding in HIV-1

Abstract Predicting how protein mutations affect drug binding remains a major challenge, particularly when the mutations are distal from the binding site. In this study, we introduce a coupled simulation workflow that combines classical molecular dynamics (MD) with high-throughpu...