Université Grenoble Alpes

Chiral-Induced Spin Selectivity as a Driving Force in Enantiorecognition: A Generator-and-Reader Perspective

Abstract Enantiorecognition is conventionally rationalized through stereochemical models, such as lock-and-key, induced-fit, and three-point interaction schemes, in which a chiral selector discriminates between enantiomers through geometry and noncovalent interactions. Neverthele...

A new transcendence measure for the values of the exponential function at algebraic arguments

Let P ∈ ℤ [ X ] ∖ { 0 } be of degree δ ≥ 1 and usual height H ≥ 1 , and let α ∈ ℚ ¯ * be of degree d ≥ 2 . Mahler proved in 1931 the following transcendence measure for e α : for any ε > 0 , there exists c > 0 such that | P ( e α ) | > c / H μ ( d , δ ) + ε where the exponent μ (...

Evidence of hydrodynamic control of phytoplankton seasonality in a tropical urban estuary

Tropical urban estuaries receive year-round nutrient loads, yet their strongest phytoplankton blooms often occur in the dry season. The proximate control on this seasonality remains unresolved in wastewater-impacted tropical systems. Here we apply a transient one-dimensional Carb...

Antifibrotic therapy in patients with pleuroparenchymal fibroelastosis: a multicentric observational study

Pleuroparenchymal fibroelastosis (PPFE) is a rare interstitial lung disease characterized by upper-lobe predominant pleural and subpleural fibrosis and associated with poor prognosis. No evidence-based medical therapy is currently established, and lung transplantation remains the...

Over 400 V Field‐Plate Enhanced Vertical Diamond Schottky Diodes With Near‐Ideal Behavior and Over 2700 A/cm 2 Current Density

Vertical diamond Schottky barrier diodes with field‐plate edge termination were fabricated on 1.5 μm low‐doped () epilayers grown on heavily boron‐doped substrates. Devices with Schottky radii of 25–350 μm and FP lengths of 0–20 μm were systematically characterized. Temperature‐d...

Brand relationships in conversation: a review of conversational agents using bibliometrics and language models

Purpose This paper aims to synthesise research on conversational agents in the context of brand relationships to map the current state of knowledge, propose an integrative framework and develop a future research agenda. Design/methodology/approach This study analyses 293 publicat...

Hydromechanical Behaviour of Intact and Recompacted Crushed Caprock for Underground CO2 Storage

Abstract This work investigates the hydromechanical behaviour of Opalinus Clay (OPA) shale as a caprock material for geological storage of CO $$_2$$ 2 . In addition to intact OPA, the hydromechanical response of crushed material is evaluated to simulate damaged zones around injec...

Mechanistic insights into Nrf2- and PARP1-mediated radioresistance of glioblastoma stem cells under photon, proton, and carbon ion irradiation: An in vitro study

Glioblastoma multiforme (GBM) exhibits strong resistance to radiotherapy, partly driven by glioblastoma stem-like cells (GSCs) with enhanced redox homeostasis and DNA repair capacity. This study evaluated whether targeting Nrf2-mediated antioxidant signaling and PARP1-dependent D...

From fluid loss to calcification: MRI and CT matrix features in cystic echinococcosis

Abstract Objective To characterize MRI matrix signal and CT calcification patterns across WHO-IWGE stages, compare them with lesion mimicking cystic echinococcosis (CE), and derive an MRI-based subclassification for inactive cysts. Materials and methods This retrospective multice...

A Frank-Wolfe-based primal heuristic for quadratic mixed-integer optimization

Abstract We propose a primal heuristic for quadratic mixed-integer problems. Our method extends the Boscia framework – originally a mixed-integer convex solver leveraging a Frank-Wolfe-based branch-and-bound approach – to address nonconvex quadratic objective functions and constr...

Matrix‐Activated Aptamer Sensors for Human Serum Analysis

ABSTRACT Owing to their ease of operation, solution‐phase fluorescent sensors hold a crucial position among aptamer‐based detection tools. However, their performance is regularly compromised when exposed to increasing levels of blood fluids, such as human serum, which limits thei...

Matrix‐Activated Aptamer Sensors for Human Serum Analysis

ABSTRACT Owing to their ease of operation, solution‐phase fluorescent sensors hold a crucial position among aptamer‐based detection tools. However, their performance is regularly compromised when exposed to increasing levels of blood fluids, such as human serum, which limits thei...

Cardiolipin deficiency disrupts electron transport chain and drives steatohepatitis

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a progressive disorder marked by lipid accumulation, leading to metabolic dysfunction-associated steatohepatitis (MASH). A key feature of the transition to MASH involves oxidative stress resulting from defects in...

Reflex seizures and epilepsy surgery: A network approach case‐based exploration

Abstract Context Reflex seizures (RS) are defined by their consistent provocation by specific stimuli, encompassing a broad range from elementary sensory inputs to complex cognitive tasks. While RS are often encountered in clinical practice, their surgical management remains spar...

Cost-utility study of cognitive-behavioural management of auditory hallucinations in schizophrenia: a study protocol

Abstract Background Auditory verbal hallucinations (AVHs) affect 60–80% of patients with schizophrenia, causing significant distress and functional impairment. Although cognitive-behavioural therapy (CBT) has been shown to reduce AVH-related distress and relapse risk, its use rem...

On the collimation properties of jets with finite Poynting flux launched from Keplerian accretion discs

Abstract It is generally accepted that the launching of astrophysical jets requires a large-scale magnetic field threading a central object (black hole or star) and/or its surrounding accretion disc. However, the collimation mechanism far away from the central object has not yet...

Elastoplastic analysis of tunnels in Hoek–Brown rock masses exhibiting strain softening

This paper proposes an adaptive ring-by-ring semi-analytical framework for elastoplastic analysis of circular tunnels in strain-softening Hoek–Brown rock under hydrostatic in-situ stress. The excavation unloading process is discretized via equal radial stress increments, with the...

Challenging the predictive coarse-to-fine hypothesis in emotional face perception

Introduction Predictive processing (PP) accounts conceptualize perception as an interaction between top-down predictions and bottom-up sensory inputs. In the visual domain, low spatial frequencies (LSF) convey coarse information, supporting early predictions, refined by high spat...

Model-Based Learning of Whittle indices

We present BLINQ , a new model-based algorithm that learns the Whittle indices of an indexable, communicating and unichain Markov Decision Process (MDP). Our approach relies on building an empirical estimate of the MDP and then computing its Whittle indices using an extended vers...

Cancer in systemic sclerosis: clinical associations and prognostic impact from the EUSTAR registry

BACKGROUND: Cancer represents a major cause of mortality in systemic sclerosis (SSc). Established risk factors are limited to specific subsets, particularly early diffuse anti-RNA polymerase III (POLR3)-positive disease, needing further exploration. METHODS: We performed a nested...