Université Grenoble Alpes

Design and Replication of Micro- and Nanotextured Polymer Surfaces: A Height-to-Pitch Criterion to Predict Hydrophobicity Enhancement

Abstract The present study examines how the replication of micro- and nanotextures on polymer surfaces enhances their hydrophobic properties and defines a geometric parameter required to obtain functional surfaces at an industrial scale. Nickel shims were fabricated by lithograph...

Magnetohydrodynamic drag on an oscillating sphere in a rotating spherical cavity

Oscillating-sphere drag is a classical fluid-mechanics problem, yet no theory simultaneously accounts for confinement, rotation, viscosity and magnetic fields. We consider a conducting sphere undergoing translational oscillations inside a rotating spherical cavity, modelling conf...

Integrating Drug Physicochemistry and Hfq-Dependent Regulation of Ciprofloxacin Accumulation in Escherichia coli

Ciprofloxacin (CIP), an amphoteric fluoroquinolone, undergoes pH-dependent changes in protonation state that influence membrane permeability and intracellular accumulation. Here, we investigated how drug physicochemistry and bacterial regulatory pathways jointly determine CIP acc...

Structural basis for size-selective perception of chitin in plants

Plants detect microbes through pattern recognition receptors that perceive conserved microbial surface motifs known as microbe-associated molecular patterns (MAMPs). Lysin motif (LysM) receptors recognize and mediate downstream responses to chitinous MAMPs. In this study, we eluc...

Ecosystem service gradients at protected area borders reveal multiple patterns and prevalent management conflicts

Protected areas cannot halt biodiversity loss in isolation; integrating them with surrounding human-dominated landscapes is critical. However, this integration is challenged by substantial landscape heterogeneity at protected area borders, making it difficult to determine cross-b...

Weight Loss and Long-Term Weight Trajectories After a Structured Nutritional and Behavioral Intervention: A Large Real-World Cohort Study

Background/Objectives: Achieving and maintaining intentional weight loss is a major challenge in routine clinical practice, and real-world evidence is limited. Methods: This retrospective cohort study evaluated initial weight loss in 56,093 adults from a total of 126,659 who comm...

Conformal data for the $O(2)$ Wilson-Fisher CFT in $(2+1)$-dimensional spacetime from exact diagonalization and matrix product states on the fuzzy sphere

We study at zero temperature a microscopic quantum spin-1 model on the fuzzy sphere that realizes the O(2) O ( 2 ) Wilson-Fisher conformal field theory (CFT) in (2+1) ( 2 + 1 ) -dimensional spacetime at a quantum critical point. Here, we use the fuzzy-sphere regularization as it...

German Vowel Contrast Discrimination by Turkish–German Bilingual Preschool Children: Effects of Age, Language Status, and Type of Bilingualism

Although bilingual vowel perception has received great interest in the past, surprisingly few studies have focused on preschool children. To shed light on this understudied age group, the present study investigated 5- to 7-year-old Turkish–German bilingual children ( n = 24), age...

Hackathon on predictive modelling in systems pharmacology: design, implementation, and outcomes

Background The growing availability of multi-omics data and machine learning methods creates both an opportunity and a challenge for the systems pharmacology community: the opportunity to model drug action at unprecedented mechanistic resolution, and the challenge of equipping a...

Topology-preserving mesh adaptation for sharp-interface multiphase PFEM

This paper presents a robust, fully Lagrangian framework based on the Particle Finite Element Method (PFEM) capable of simulating multiphase flows with an arbitrary number of immiscible phases. Interface-capturing methods can suffer from numerical diffusion, while interface-track...

Adsorption at Interfaces and Contact Lines: From Molecular Oversolubility to Macroscopic Wetting

Abstract Interfaces between two phases and contact lines between three phases are the locus of complex phenomena that govern the thermodynamic and dynamic behavior of such systems─both at the microscopic and macroscopic scales. Yet, despite the abundant literature on the topic, t...

Non-linear mechanical field reconstruction coupling recurrent neural networks with physics-informed graph neural networks

Reconstructing local stress fields in heterogeneous microstructures under non-linear, history-dependent loading remains a major computational bottleneck in multi-scale simulations. We propose a coupled LSTM-GNN framework that links the temporal and spatial aspects of local stress...

Temperature sensitivity of snow viscoplasticity: Evidence from controlled creep experiments

Abstract. Snow is a warm, porous material whose densification under its own weight is highly temperature-dependent. Despite decades of research, reported activation energies for snow viscoplasticity remain highly scattered, ranging from 40 to 600 kJ mol-1. We quantified the tempe...

Efficacy and safety of temporary selective portal vein embolization before major hepatectomy (EMBORES): a phase 2 trial

Background Portal vein embolization (PVE) is routinely used before major hepatectomy to induce hypertrophy of the future liver remnant (FLR) and reduce post-hepatectomy liver failure. Conventional PVE relies on permanent embolic agents, resulting in irreversible portal occlusion,...

Superinfection exclusion strategy of siphophage T5: analysis of the FhuA:Llp complex

ABSTRACT Superinfection exclusion is a widespread viral mechanism that protects the infected cell from overinfection by other identical or closely related viruses. Shortly after infection by bacteriophage T5, the bacterium Escherichia coli produces Llp, encoded by the newly injec...

Guidelines for Decisions to Withhold or Withdraw Life-Sustaining Treatments (LST) in Adult ICU

OBJECTIVE: The French Society of Anaesthesia and Intensive Care Medicine (Société française d'anesthésie et de réanimation, SFAR) and the French Society of Physical Medicine and Rehabilitation (Société Française de Médecine Physique et de Réadaptation (SOFMER)) aimed at providing...

Does the Inclusion of Foreign‐Based Players Influence the Performance of National Teams at AFCON Tournaments?

ABSTRACT Team composition in sports rarely considers the significant mix of players in a national team's tournament performance. This study theorises that the mere inclusion of foreign‐based nationals is not enough to guarantee team success, especially in the African Cup of Natio...

Wavelength-Selective Magneto-Optical Diodes Based on Rare-Earth Chiral Molecular Crystals

Abstract Chiral materials, integrating structural breaking of mirror-symmetry, exhibit physical properties that cannot be observed in centrosymmetric analogues. Among these properties, optical magneto-chiral anisotropy, the nonreciprocal absorption of light shown by chiral magnet...

Reflector‐Free, Highly Confined Love‐Like SAWs Enabled by a Phononic Metasurface for Real‐Time Monitoring of Cell Dynamics

ABSTRACT Surface acoustic wave (SAW) devices are widely used in sensing and biosensing but generally suffer from strong attenuation in liquid environments. Conventional approaches rely on reflectors to reduce these losses, yet these components remain difficult to optimize: limite...

Tuning the Architecture of High-Density Bottlebrush Block Copolymers to Control Their Photonic Properties

Abstract The backbone rigidity of bottlebrush block copolymers (BBCPs) induced by the dense branches distributed along their polymeric backbones has made them materials of interest for fast self-assembly of photonic materials. Today, the rigidity of BBCPs is limited by the maximu...