Lyon 1 Université

Real-World Use of Adjuvant Nivolumab for Resected Stage III–IV Melanoma: 2-Year Analysis of AdjuMel

Following the positive findings of the phase 3 CheckMate 238 trial, adjuvant nivolumab has become a standard therapy in patients with completely resected stage III–IV melanoma. The prospective, ongoing AdjuMel study is evaluating the real-world use, effectiveness, and safety of a...

Death determination at the bedside: clinical judgement beyond criteria

In clinical practice, death determination—a core responsibility of critical care clinicians—is commonly taught as the technical application of standardized medical and legal criteria. However, contemporary practices, including resuscitation, death determination by neurological cr...

Oak masting under climate change: when spatially heterogeneous shifts in flowering phenology reshape pollen limitation

Masting, the irregular, synchronised production of seeds within tree populations, drives forest regeneration and ecosystem dynamics. Its response to climate change may depend on phenological shifts in key reproductive stages, yet this link remains poorly understood. Using 30 yr o...

Deep molecular profiling of lung neuroendocrine tumours and supra-carcinoids

BACKGROUND: Lung neuroendocrine tumours (NETs, also known as carcinoids) are rapidly rising in incidence worldwide but have unknown aetiology and limited therapeutic options beyond surgery. The current WHO classification, based on mitotic count and presence or absence of necrosis...

On quasi-homomorphism rigidity for lattices in simple algebraic groups

Property (TTT) was introduced by Ozawa as a strengthening of Kazhdan’s property (T) and Burger and Monod’s property (TT) . In this paper, we improve Ozawa’s result by showing that any simple algebraic group of rank \geq 2 over a local field has property (TTT) . We also show that...

Quantum Entropic Relationalism (QER): Contemporary Debates and Theoretical Frontiers

Entropy has evolved from a secondary thermodynamic property (Clausius, 1865) to a potentially fundamental organizing structure of physical reality, particularly through its gravitational manifestation in the Bekenstein–Hawking formula. This article systematically reviews four the...

Simulation-based inference of epidemiological and phylodynamic models via neural posterior estimation

Mathematical models play a central role in understanding and forecasting infectious disease dynamics, but parameter inference is often difficult when likelihoods are intractable. Simulation-based inference (SBI) circumvents this limitation by relying on model simulations. Traditi...

Active learning strategies for the estimation of a feasible set defined from a vector output black-box simulator

Many industrial problems require the use of black-box numerical simulators, for which it is essential to determine the set of so-called feasible input parameters. A set of parameters is feasible if the output of the code on these parameters satisfies given constraints, for exampl...

SRF fusion oncogenes encode constitutively activated chimeric transcription factors in myoid soft tissue tumors

ABSTRACT SRF fusion genes drive the pathogenesis of muscle-related soft tissue tumors, including subsets of perivascular tumors, inflammatory myofibroblastic tumor, and rhabdomyosarcoma. SRF encodes Serum Response Factor, a well-characterized transcription factor that regulates m...

Bioprosthetic Valve Failure After Transcatheter Aortic Valve Replacement

BACKGROUND: Data on the long-term incidence and clinical impact of bioprosthetic valve failure (BVF) after transcatheter aortic valve replacement remain limited. This study aimed to assess the incidence, predictors, and clinical impact of BVF following transcatheter aortic valve...

Early development of anoxia prior to the main euxinic phase of the Jenkyns Event on the margin of the Western Tethys (Sachrang Basin, Eastern Alps)

ABSTRACT Although the global expansion of oxygen‐depleted marine environments during the Early Toarcian Jenkyns Event (or Toarcian Oceanic Anoxic Event) is primarily inferred from successions in the NW European epicontinental basins, the timing of the expansion of anoxia in Tethy...

The Recognition and Vulnerability of Olympic Sports: The Case of Basque Pelota (1900–1992)

The path to Olympic recognition remains challenging for many disciplines. While some sports successfully navigate this road, traditional and regional sports face significant barriers. Basque pelota exemplifies these difficulties. Its case highlights the challenges a sport can fac...

Tricking Turing: How to Build a Geometric Checkerboard on Living Tissue

The snake’s head fritillary (Fritillaria meleagris) displays one of the rarest pigmentation motifs in the plant kingdom: a high-contrast checkerboard of alternating purple and white domains on its tepals. Standard reaction–diffusion theory does not generically produce this patter...

In vivo quantification of polyethylene wear in total ankle arthroplasty

Aims In vivo assessment of polyethylene (PE) wear in total ankle arthroplasty (TAA) relies on approximation using 2D metal interspace height (2D-MIH) loss on weightbearing radiographs. Weightbearing CT (WBCT), combined with distance mapping, may improve quantification of PE wear...

Breast cancer metabolism and responsiveness to dichloroacetate: relationships with 15N and 13C natural abundance

Abstract Background Metabolic reprogramming is a hallmark of breast cancer (BrCa), with alterations in glycolysis, glutamine metabolism, and the urea cycle contributing to tumour progression. Dichloroacetate (DCA), a pyruvate dehydrogenase kinase (PDK) inhibitor, shifts metabolis...

Tail Modulo Async-Await

This article extends tail-call optimisation by applying it to asynchronous calls. We first introduce TMA, a novel code transformation for asynchronous tail recursive functions that prevents the creation of unnecessary tasks. We then show how to combine TMA with the existing TMC o...

Timing of antifibrotic therapy and prognosis in idiopathic pulmonary fibrosis: real-world evidence from the French Colibri-ILD SNDS database

According to the French 2022 National guideline, antifibrotic therapy should be initiated as soon as a diagnosis of idiopathic pulmonary fibrosis (IPF) is made, taking into account the individual assessment of the expected benefit and risks of treatment. However, in practice, tre...

Neutron elastic scattering at $$\varvec{30.8}$$ MeV on $$\varvec{^{\text {nat}}\textrm{Ce}}$$

Abstract Elastic scattering of fast neutrons at an incident energy of 30.8 MeV on a natural cerium target was measured during an experiment conducted at the Neutrons For Science facility at GANIL-SPIRAL2. This is the first measurement on cerium using incident neutron energy above...

Morphological and Size‐Dependent Enrichment of Endotoxins in Coastal Spray Aerosols: Implications for Regional Respiratory Health Risks

Abstract Sea spray aerosols (SSA) transport bioactive substances that affect the Earth's environmental and climate system. We investigated the enrichment of endotoxins (LPS), characterized their influence on the SSA morphologies, and evaluated the respiratory tract deposition. LP...

Exploring the feasibility of an air sensor array for real-time detection and characterization of VOCs

Abstract. Volatile organic compounds (VOCs) are an important class of atmospheric chemical species that can be directly harmful to human health and contribute to the formation of hazardous secondary products. Measurements of ambient VOCs are typically made using “offline” techniq...