Lyon 1 Université

STABILOOP, a cohort trial to assess automated insulin delivery in the management of patients living with type 1 diabetes who are eligible for islet transplantation

A limited subset of people living with type 1 diabetes (T1D) is affected by extreme glycemic lability and frequent unpredictable severe hypoglycemia, significantly impairing quality of life and associated with higher morbidity, mortality, and healthcare costs. Islet transplantati...

The Orbitofrontal Expansion for Extending Nasoseptal Flap Reach in the Frontal Sinus

Abstract Skull base defects involving the superior and lateral posterior table of the frontal sinus are challenging to reconstruct due to limited surgical access and restricted reach of available reconstructive options. External approaches are often required, increasing morbidity...

Contribution of One‐Electron Oxidation of Purine and Pyrimidine Bases to the Photo‐ and Radiation‐Induced Damage to Cellular DNA

One‐electron oxidants that include type I photosensitizers, biologically relevant carbonate anion radical generators, and high intensity UVC nanosecond lasers are able to ionize in aqueous solution purine and pyrimidine nucleobases. The survey is aimed at critically reviewing the...

No gender differences in predictive processing

Abstract Statistical learning, defined as the implicit extraction of environmental regularities, is considered a fundamental cognitive mechanism that supports predictive processing across individuals, domains, and species. However, whether it is modulated by gender remains unclea...

Vancomycin optimised dosing regimens for critically ill patients receiving renal replacement therapy

Optimal dosing of vancomycin in critically ill patients receiving renal replacement therapy (RRT) is uncertain due to high pharmacokinetic variability. We aimed to develop individualised vancomycin dosing recommendations that optimise efficacy while minimising toxicity. Prospecti...

Optimizing Voice-Based Feature Engineering and Machine Learning Pipelines for Early Parkinson’s Disease Detection

Most voice-based Parkinson’s disease studies evaluated a narrow set of models on fixed feature spaces, which limited generalizability and obscured feature–model synergies. Many also neglected fold-wise fitting and runtime measurement, increasing the risk of data leakage and hinde...

Pancreatic panniculitis as the sole manifestation of pancreatic ductal adenocarcinoma: a case report

Pancreatic panniculitis is a rare form of lobular panniculitis characterized by subcutaneous fat necrosis occurring at cutaneous sites distant from the pancreas. It is most often associated with pancreatitis, while pancreatic malignancies — dominated by acinar cell carcinoma — re...