Lyon 1 Université

The HEADSpAcE Data Center: An international data and biospecimen resource for head and neck cancer translational research

Head and neck cancer (HNC) comprises a heterogeneous group of malignancies with substantial variation in incidence, risk factors, and outcomes across populations. Existing studies are often limited by regional scope or lack integration of epidemiological, clinical, and molecular...

Clinical and ecological significance of bacterial dormancy in human pathogens

SUMMARY Bacteria can enter a transient state of reduced metabolic activity to survive temporary unfavorable conditions. This phenomenon, sometimes referred to as dormancy, growth arrest, or quiescence, enables pathogen survival inside and outside of their host, with major clinica...

A common germline 3′ UTR variant controls DDIT4 translation efficiency and stress responses in cancer cells

Systematic strategies for identifying and classifying variants that directly modulate ribosome engagement are lacking. Here, we develop and extensively validate a pipeline to identify translation-associated single-nucleotide polymorphisms (tranSNPs) by integrating analysis of tot...

Weighting of Spectral and Temporal Cues with n-of-m Cochlear Implant Strategies Depends on Voice Pitch

Abstract Purpose The relative contributions of spectral and temporal cues to voice pitch perception in cochlear implant (CI) users remain unclear. This study aimed to directly quantify these contributions in dynamic speech stimuli with clinical n -of- m processors. Methods Fundam...

Spatiotemporal variation of the chick mass-brood size trade-off in the little owl

Abstract Resources are limited and cannot be used for multiple functions simultaneously, leading to trade-offs between life-history traits. The detection of such trade-offs depends on resource acquisition (total amount of resources) and allocation (distribution of resources betwe...

Temporal trends and seasonal patterns of violent crime in France

Violent behavior is a major public health concern, yet whether different forms of violent crime follow similar or distinct seasonal patterns remains unclear. We analyzed monthly national counts of police-recorded violent offenses in France from January 2016 to December 2024 using...

Development of ultrafast and radiation-hard GAGG for the next-generation of High-Energy Physics calorimeters

The evolution of High Energy Physics (HEP) toward future collider experiments with High Luminosity (HL), such as the HL-LHC, requires the development of scintillating materials that combine high density, excellent radiation hardness and an ultrafast response. While Cerium-doped G...

Sensitivity of neutrino oscillations to the Earth’s interior properties

Understanding the Earth’s deep interior remains challenging, as traditional geophysical methods face ambiguities in linking seismic observations to temperature, composition, or mass density variations. Atmospheric neutrinos, produced by the constant flux of cosmic rays colliding...

Arid grown coriander essential oil and linalool: effects of microencapsulation on the control of Staphylococcus aureus in minced sheep meat

Natural preservation strategies using essential oils are gaining momentum, but their volatility and reactivity limit their application in complex food systems where pathogenic bacteria like Staphylococcus aureus remain a persistent challenge. This study addresses this gap by firs...

Unlocking the Full Potential of Taylor Dispersion Analysis Through Advanced Detection

Today, pharmaceutical sciences rely on a wide range of innovative therapeutics of varying sizes: nanoparticles, proteins, antibodies, and nanocarriers for drug delivery. Measuring their size is one of the crucial parameters in their characterization, to ensure drug safety, stabil...

Free Radical Multiphase Chemistry on Tropospheric Photoreactive Particles

Abstract Gas-phase and multiphase reactions of free radicals play pivotal roles in tropospheric chemistry. Recent studies indicate that photoinduced multiphase reactions serve as a potential source of free radicals rather than a traditional sink. To accurately evaluate their envi...

MRI Characteristics of Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease

Importance Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is a demyelinating disease distinct from multiple sclerosis (MS) and aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder (AQP4+NMOSD). Magnetic resonance imaging (MRI) is central t...

From Versioned Cities to Versioned Documents: Extending CityRDF for Modelling Urban Documentation over Time

Cities are documented by large and heterogeneous multimedia corpora, including photographs, maps, plans, reports, videos, and web resources. While versioned urban models have been studied for representing the temporal evolution of city objects, the documents describing these obje...

SENIOR ‐ IPI : An easily applicable prognostic index for first‐line large B‐cell lymphomas patients >80 years treated with curative intent

Summary Using LYmphoma Study Association clinical trials combining 438 first‐line large B‐cell lymphomas (LBCL) patients >80 years old, we defined SENIOR‐IPI, an easily applicable prognostic index for this elderly population treated with an anti‐CD20‐miniCHOP (cyclophosphamide, d...

Serum GFAP and Age Accurately Distinguish AQP4 ‐ IgG Positive and Double Seronegative NMOSD From MOGAD After a Recent Attack

BACKGROUND: Serum neurofilament-light chain (sNfL) and glial fibrillary acidic protein (sGFAP) are associated with multiple sclerosis (MS) activity. This study aimed to identify patient- and disease-level determinants of sNfL and sGFAP and to evaluate their ability to support dif...

Potential for real-time health and welfare monitoring of red fox (Vulpes vulpes) in experimental settings using implants

Monitoring and improving animal health and welfare is a pressing need. Technological advances are increasing our ability to do so in a range of settings but there are limited uses in experimental settings for less common model animals. Red foxes ( Vulpes vulpes ) are maintained b...

Tailoring attosecond charge migration in native molecular ions

Attosecond chemistry involves developing strategies to manipulate electronic coherent waves in molecules, which can influence the outcome of photoinduced reactions. While recent progress in this field calls for investigations of increasingly complex isolated or embedded systems,...

Interfacial Structuring and Functional Enhancement in Pectin-Sodium Caseinate Films Loaded with Deverra tortuosa Essential Oil Nanoemulsions

This study aimed to develop bioactive pectin-based films incorporating Deverra tortuosa (D. tortuosa) essential oil (EO) nanoemulsions stabilized by sodium caseinate for potential active food packaging applications. EO nanoemulsions were incorporated into a pectin–maltodextrin ma...

A cross-species atlas platform for comparative neuroscience in teleost fish

Abstract Uncovering general principles connecting neural circuits to behaviour requires comparative brain analyses across species. To advance these efforts, we developed a standardised workflow and a unified brain atlas platform for the quantitative comparison of neural structure...

A structure-preserving method of fundamental solutions for the multi-phase Mullins–Sekerka flow

A charge simulation method, a variant of the method of fundamental solutions, is applied to approximate the multi-phase Mullins–Sekerka flow in R 2 and in a half-plane H bounded by a Neumann wall W . In the underlying mathematical model, interfaces driven by their curvature are c...