Universidade Federal de São Paulo

Multifunctional NaNbO3: Photocatalytic Degradation of Methylene Blue and Intrinsic Antimicrobial Activity against Enterococcus faecalis and Candida albicans

Abstract In this paper, sodium niobate (NaNbO3) was synthesized by the microwave-assisted hydrothermal method at 150 °C for 70 min, followed by calcination at 550 °C for 2 h. X-ray diffraction revealed the coexistence of orthorhombic P21ma and Pbma phases, while scanning electron...

Role of aerobic exercise training on myocardial infarction induced-cardiac dysfunction, dysautonomia and oxidative stress in female ob/ob mice.

We investigated the effects of aerobic exercise training (ET) on cardiac function, autonomic modulation, and inflammatory and oxidative stress markers in an experimental model of diabetes and obesity underwent myocardial infarction (MI). Female ob/ob mice were randomized into: sh...

Are Selenium Status and Inflammation Linked to Cardiometabolic Risk Factors in Inborn Errors of Immunity?

Background/Objective: Patients with Inborn Errors of Immunity (IEI) are at increased cardiometabolic risk due to inflammation, immune dysfunction, and oxidative stress. Given selenium’s essential role in antioxidant defense, this study evaluated plasma selenium concentration in i...

Clinical and Epidemiological Profile of Children Evaluated at a Public Pediatric Cardiology Service in Southern Brazil

Background/Objectives: Congenital heart disease (CHD) is a major cause of congenital morbidity and mortality, but evidence from public pediatric cardiology services in Brazil remains limited. This study aimed to characterize the clinical and epidemiological profile of children an...

Toward a Langmuir-monolayer-based protocol for assessing the mucoadhesion of gold nanoparticles intended for ophthalmological drug-delivery applications

This study aims to establish a Langmuir-monolayer-based protocol to assess the mucoadhesion of gold nanoparticles intended for ophthalmological drug-delivery applications. Using Langmuir monolayers to model the tear film and corneal epithelial membrane, mucins were found to inter...

Real-world treatment patterns and healthcare utilization following omalizumab initiation in chronic spontaneous urticaria: a nationwide Brazilian cohort study

Abstract Chronic spontaneous urticaria (CSU) is a relapsing inflammatory skin disease associated with substantial symptom burden and repeated healthcare use. Omalizumab is recommended for patients whose disease remains uncontrolled despite second-generation H1-antihistamines, yet...

Interleukin-17RA polymorphisms rs887796 and rs1468488 are not associated with gastric cancer

Abstract Background Gastric cancer is a multifactorial disease in which Helicobacter pylori ( H. pylori ) infection plays a central carcinogenic role through inflammation mediated by cytokines, including interleukin-17 (IL-17). The IL-17RA receptor is a key component of this sign...

Low-pressure pneumoperitoneum in robot-assisted radical prostatectomy: a systematic review, meta-analysis and trial sequential analysis of randomized controlled trials

Abstract Purpose Low-pressure (LP) pneumoperitoneum (intra-abdominal pressure [IAP] <12 mmHg) has been proposed to reduce pain after robot-assisted radical prostatectomy (RARP), but earlier syntheses combined randomized with non-randomized data, pooled mixed urological procedures...

Random‐key optimization for 2D irregular packing with reusable area evaluation

Abstract The diverse constraints of industrial applications lead to variants of two‐dimensional (2D) irregular packing problems that require tailored solution methods. This paper addresses a real‐world industrial challenge by proposing a new problem definition, the maximum reusab...

Oxygen-Vacancy-Controlled Band-Gap Engineering in Fe/Co Co-doped La-Modified Bismuth Titanate: Integrated Experimental and First-Principles Analysis

Abstract Layered Aurivillius ferroelectrics offer a route to multifunctional band-gap engineering, yet the role of oxygen vacancies in band-edge reconstruction in Fe/Co-modified compositions remains poorly resolved. Here, oxygen annealing of Bi3.25La0.75Ti2.60(Fe0.50,Co0.50)0.40O...

Differences in corneal biomechanical parameters in normal tension glaucoma versus normotensive glaucoma suspect eyes

Abstract Multicenter retrospective study to evaluate differences in corneal biomechanical parameters provided by Corvis ST to segregate those with normal tension glaucoma (NTG) from glaucoma suspects. We included only newly diagnosed and treatment naïve glaucoma patients. Several...

Artificial intelligence for Amazonian health: validation is the price of entry

At the AI as Catalyst meeting in Manaus (July 28–29, 2026; https://ia-como-catalisadora-manaus.netlify.app), participants ran a simple exercise. Working in teams, they wrote about ten clinical cases and put each one to widely used general-purpose chatbots twice: first in standard...

Evolutionary Dynamics-Aware De Novo Design of a Thermostable NS1-Derived Diagnostic Protein for Yellow Fever Virus

Abstract Serological diagnosis of neglected arboviruses remains hindered by extensive intra-genus cross-reactivity, compromising both assay specificity and epidemiological accuracy. In this study, we focused on yellow fever virus (YFV) as a model system to design and validate a g...

Use of hormonal intrauterine device and quarterly injection for contraception in adolescents with mental disorders

Objective: To evaluate the continuity and satisfaction rate with contraceptive methods over 12 months in female adolescents with mental disorders (MD). Material and Methods: Prospective cohort study carried out at a reference center for care for adolescents with MD. Adolescents w...

Micro- and Nanoplastics in the Human Exposome: Environmental Pathways, Kidney Toxicity, and Implications for Public Health Risk Assessment

Plastic pollution has emerged as a global environmental and public health crisis, with micro- and nanoplastics (MNPs) representing a pervasive component of the human exposome. Generated through the continuous fragmentation of larger plastic materials, MNPs exhibit physicochemical...

Sexual Dimorphism and Intraspecific Toxin Variation in Crotalus durissus terrificus Venom: Insights from Proteomics, Peptidomics, and Structural Modeling

Abstract The venom of the South American rattlesnake Crotalus durissus terrificus (Cdt) is renowned for its minimalist yet highly toxic arsenal. Intraspecific variability in expressed proteoforms and toxin content has been previously observed in Cdt venom, resulting in heterogene...

Pilot evaluation of pathogen isolation using targeted amplicon next-generation sequencing on sonication fluid for the diagnosis of periprosthetic joint infections

Abstract Background Periprosthetic joint infection (PJI) remains difficult to diagnose due to the limited sensitivity of conventional culture, which frequently yields false-negative results. Targeted amplicon next-generation sequencing (tNGS) offers a method capable of identifyin...

Mindfulness in the Brazilian National Health System (SUS): Why Training Instructors Is Not Expensive but Strategic and Cost-Effective

BACKGROUND: It is often argued that training mindfulness instructors would be too expensive to be feasible within a public health system such as Brazil’s Unified Health System (SUS). This essay challenges that perception by combining epidemiological estimates, cost analysis, and...

Assessing the agreement and reliability of Magene ® for heart rate monitoring

To evaluate the accuracy and reliability of the Magene ® heart rate (HR) monitor compared to the Polar ® H7 (validated device) during rest, maximal graded exercise test, and active recovery. A within-group study was conducted with 68 healthy adults (21 women). Participants comple...

PIK3CA silencing restores anoikis sensitivity in endothelial cells

Abstract Background The development, differentiation, and homeostasis of adherent cells are regulated by interactions among cells, the extracellular matrix (ECM), and soluble factors. Loss of these contacts induces anoikis, a specific form of apoptosis. Tumor cells acquire resist...