Universidade Federal de São Paulo

Schizophrenia research in 2026: report from the annual meeting of the Schizophrenia International Research Society

Abstract SIRS 2026, held under the theme “Schizophrenia Research in the Era of Artificial Intelligence,” brought together researchers, clinicians, and persons with lived experience to take stock of a field whose tools for measuring, predicting, and intervening in psychosis have e...

Task force of the Brazilian Society of Otology and the Brazilian Academy of Neurotology: Menière’s Disease

Objective To critically review the available evidence on the pathophysiology and diagnosis of Menière’s disease and to provide consensus-based recommendations developed by a task force of the Brazilian Society of Otology and the Brazilian Academy of Neurotology. Methods A task fo...

Globalising the access to advanced molecular diagnostics of CNS tumors: Experience of the Molecular Neuro-Pathology (MNP) Outreach Consortium

Central nervous system (CNS) tumors pose a major global health challenge, particularly in low- and middle-income countries (LMICs), where outcomes remain disproportionately poor. The global CONCORD-3 study (Lancet Oncology) highlighted stark disparities in five-year survival (201...

The use of real‐world data in health services research for dementia care: A scoping review

Abstract Health services research (HSR) is critical to informing dementia care and often relies on real‐world data (RWD); however, RWD use in HSR has not been systematically mapped in the United States. Following previous researchers and Preferred Reporting Items for Systematic R...

Perinatal Outcomes of Pleuro-Amniotic Shunting in Isolated Pleural Effusions: Systematic Review and Meta-analysis

Pleuro-amniotic shunting has been proposed for fetal pleural effusion, although its safety and efficacy remain uncertain. Therefore, we aimed to evaluate the perinatal outcomes of the fetal therapy for isolated pleural effusion through a systematic review and single-arm meta-anal...

Thermal stability and CO₂ adsorption–desorption performance of synthetic hectorite and its CeO₂/NiO nanocomposites

Understanding the properties of clay minerals is crucial for developing efficient adsorbent and catalytic materials, creating new options for carbon capture technologies (CCT). This study investigates for the first time the thermal stability of synthetic hectorite (Hec), a smecti...

Beetroot Extract Microencapsulated with Modified Starch and the Amino Acids L-Aspartic Acid, L-Tyrosine, and L-Lysine: Application of the Powders in the Formulation of Gelatin Gels

The objective of this study was to evaluate the effects of the amino acids L-tyrosine (TYR), L-aspartic acid (ASP), and L-lysine (LYS) on the physical and physicochemical properties of freeze-dried beetroot extract powder produced using modified starch with octenyl succinic anhyd...

Few bilinear operators on spaces of continuous functions

Motivated by recent work exhibiting a locally compact scattered space L constructed under Ostaszewski’s ♣-principle, which yielded a complete classification of linear operators on C0(L×L), we extend the analysis to the bilinear setting. We show that, for this space L, every bilin...

Switching From Originator to Biosimilar Infliximab in Pediatric Inflammatory Bowel Disease: A Systematic Review and Meta‐Analysis

ABSTRACT Background and Aims Switching from originator infliximab to a biosimilar has become routine in adults with inflammatory bowel disease, but pediatric‐specific evidence remains limited. We aimed to evaluate the efficacy and safety of this switch in patients younger than 22...

Chelsea critical care physical assessment tool (CPAx) for adult patients hospitalized in the ward: measurement properties

Objective To evaluate the measurement properties of the Brazilian version of the Chelsea Critical Care Physical Assessment Tool (CPAx-Br) and evaluate the evidence of validity in adult general ward patients, extending its application beyond the critical care setting for which it...

Dengue infection in kidney transplant recipients during a major epidemic and the implementation of systematic donor screening: a cohort study

Background During Brazil's unprecedented dengue epidemic in 2023–2025, we develop a rationale for organ donor screening to mitigate the risk of donor derived transmission using rapid, widely available, and low-cost tests. Here we aimed to describe the epidemiology, clinical prese...

Circadian dysregulation of leptin and its role in skin inflammation and obesity: an integrative perspective

Abstract Purpose Leptin is an adipokine that regulates energy balance and is commonly linked to obesity. It exhibits a circadian rhythm that can be disrupted by variations in eating times and sleep disorders. This brief review explored how leptin can modulate appetite and tissue...

Repurposing the Insecticide Flufenerim, the Only Anti- Cryptococcus Compound Identified in the MMV Global Health Priority Box, as a Candidate for the Environmental Control of the Cryptococcosis Agents

Abstract Cryptococcus neoformans and Cryptococcus gattii are environmental fungi that cause cryptococcosis, a severe, life-threatening infection, particularly in immunocompromised individuals. Current treatments are limited by toxicity, restricted availability, and the emergence...

Genetic Counseling

Abstract Purpose of Review This review aims to provide a brief historical overview of genetic counseling and its evolution, addressing the qualified professionals and clinical requirements necessary to obtain a diagnosis and post-test guidance across different stages of patients'...

Could the use of melatonin be a promising complementary strategy in the prevention of skin cancer?

Abstract Skin cancer, including both non-melanoma and melanoma types, remains the most common neoplasm worldwide. Given its rising incidence, limitations of current therapies, and the challenges of effective prevention, novel therapeutic and preventive strategies are needed. One...

Influence of the type of facial pattern on the outcome of treatment of patients with obstructive sleep-disordered breathing with an intraoral appliance

Objectives To evaluate whether the type of facial pattern obtained from standardized photographs influences the success of treatment with Oral Appliance (OA) in a group of patients with Obstructive Sleep Disorders (OSD), and to verify the agreement between three examiners regardi...

Mucin- and mucus-related phenotypes and in vitro interaction of extraintestinal pathogenic Escherichia coli with human pulmonary cells

Abstract Background Extraintestinal pathogenic Escherichia coli (ExPEC) is a major cause of urinary tract infections (UTI), bacteremia, and meningitis. Although ExPEC have also been associated with pneumonia, the virulence mechanisms that enable colonization and infection remain...

Detailed Analysis of Intraretinal Layers and Their Correlation to Brain Structures in Normal Healthy Aging

Purpose: The purpose of this study was to investigate the relationships between intraretinal layer volumes and visual cortical thickness in healthy individuals and determine the influence of age on these associations. Methods: Fifty-three subjects were recruited. One eye per subj...

International Modified Delphi Consensus on Assessment and Management of Covert Brain Infarction

BackgroundCovert brain infarction (CBI) is a frequent incidental neuroradiological finding increasingly recognized as clinically relevant due to its association with stroke, cognitive decline, and other adverse outcomes. However, substantial uncertainty remains regarding its opti...

Is Sleep Bruxism Associated With General Quality of Life? Insights From the EPISONO Population‐Based Study

ABSTRACT Aim The aim of this study is to evaluate the association between sleep bruxism (SB) and general quality of life (QoL) among adults. Methods This cross‐sectional study was conducted with a sample of 692 adults who completed the WHOQOL‐Bref questionnaire (mean age of 50.1...