Universidade Federal de São Paulo

Endoscopic third ventriculostomy for diencephalosynapsis-related hydrocephalus in MPDZ gene syndrome: a case report and review of the literature

Abstract Purpose MPDZ syndrome is a rare autosomal recessive disorder caused by biallelic pathogenic variants in MPDZ (9p23) and typically managed with ventriculoperitoneal shunting (VPS). Recent characterization of MPDZ-related hydrocephalus as an obstructive process—driven by d...

Phage heteroresistance in clinical Klebsiella pneumoniae isolates: impact of differentiated capsule expression on phage efficacy

Abstract Heteroresistance, commonly described in the context of antibiotics, refers to the presence of resistant subpopulations within a bacterial strain, and is recognized as a likely contributor to treatment failure. Whether population heterogeneity affects phage activity remai...

Cognitive Functional Therapy for Plantar Heel Pain: A Case Series

BACKGROUND: Plantar heel pain is a prevalent musculoskeletal condition frequently associated with persistent pain, disability, and biopsychosocial contributors. Although guideline-based care has evolved, management often remains centered on passive and tissue-focused strategies,...

Subchronic Exposure to Cannabis‐Based Nanoemulsions Induces Histopathological and Molecular Alterations in the Rat Submandibular Gland

ABSTRACT The increasing therapeutic incorporation of cannabis has expanded phytocannabinoid application, yet peripheral adverse effects like xerostomia raise concerns regarding emerging biotechnological formulations. This study evaluated the effects of cannabis‐based lipid nanoem...

Schools as youth-friendly climate shelters: co-designing socio-spatial infrastructures of care for urban heat adaptation

Urban heat is unevenly distributed, while adaptation often overlooks young people’s lived experiences. This study examines how embodied and emotional experiences, everyday spatial practices, and participatory co-design inform youth-friendly climate shelters as socio-spatial infra...

Land transformation driven by wind and solar development in Brazilian municipalities

Abstract In the last decade, Brazil’s energy sector has been moved from an exclusively hydroelectric and thermal mix to incorporate large-scale production of wind and solar photovoltaic energy. This energy transition is synchronized with the global imperative to reduce greenhouse...

ATM mutations in myelodysplastic neoplasms, acute myeloid leukemia, and myeloproliferative neoplasms: a systematic review

Abstract Ataxia Telangiectasia Mutated ( ATM ), a central kinase in the DNA damage response, is recurrently altered across these disorders, including myelodysplastic neoplasms (MDS), acute myeloid leukemia (AML), and myeloproliferative neoplasms (MPN), yet its clinical significan...

Meta-analysis of NPC2-mediated cholesterol transport in human cancers as a prognostic biomarker with therapeutic implications

NPC2 is a lysosomal cholesterol transporter involved in intracellular lipid trafficking and cholesterol homeostasis, processes that have been increasingly implicated in cancer biology. To quantify the clinical impact of NPC2 expression across human malignancies, we analyzed survi...

Circulating blood biomarkers after traumatic brain injury: A subanalysis of the biperiden phase III randomized, double‐blind clinical trial ( NCT01048138 )

OBJECTIVE: Traumatic brain injury (TBI) is a leading cause of acquired epilepsy, death, and long-term disability, yet reliable biomarkers to predict chronic sequelae such as post-traumatic epilepsy (PTE) remain limited. We evaluated the associations between circulating blood biom...

Testosterone replacement therapy in Parkinson’s disease a narrative review of current evidence

Abstract Testosterone is a steroid hormone primarily produced by the male gonads. It performs several critical physiological functions, such as maintaining sexual health and promoting the development of muscle mass and bone density. Additionally, testosterone plays a vital role i...

Is there an interaction between hypertension and proteinuria in pediatric chronic kidney disease progression? Evidence from the SP-CKD-Kids cohort

Abstract Background Hypertension and proteinuria are established risk factors for chronic kidney disease (CKD) progression in children. Given their pathophysiological interrelationship, whether their coexistence produces a multiplicative interaction remains uncertain. We evaluate...

Epoxidation of ent-pimara-8(14),15-dien-19-oic acid by whole cells of the endophytic fungus Aspergillus sclerotiorum

Abstract The diterpene ent -pimara-8(14),15-dien-19-oic acid ( 1 ) was converted into four oxidized diterpenes, 15,16-epoxy- ent -pimar-8(14)-en-19-oic acid ( 1a ), 15,16-epoxy-17-hydrxy- ent -pimar-8(14)-en-19-oic acid ( 1b ), 15,16-dihydroxy- ent -pimar-8(14)-en-19-oic acid ( 1...

Dietary Approaches to Obstructive Sleep Apnea: Translating Mechanistic Pathways into Clinical Practice

Obstructive sleep apnea (OSA) is a highly prevalent and heterogeneous sleep disorder characterized by recurrent upper airway collapse during sleep, resulting in intermittent hypoxia, sleep fragmentation, sympathetic activation, and increased cardiometabolic risk. Although obesity...

NRF2 signaling drives chemoresistance in NSCLC and glioblastoma

Although great advances have been made in cancer treatment, lung cancer and glioblastoma patients continue to present a dismal prognosis, mainly due to drug resistance. Evidence suggests that NRF2 and glutathione (GSH) play a fundamental role in chemotherapy resistance. Notably,...

Structural integrity of the distal femoral growth plate following radial pressure wave exposure in immature Wistar rats

Extracorporeal mechanical wave therapies are widely used for musculoskeletal disorders, but their effects on immature skeletal structures, particularly the growth plate, remain insufficiently understood. This study evaluated the histological and structural effects of repeated rad...

Might cannabis Legalization Have Affected Public Health-Relevant Alcohol- and Tobacco-use Outcomes in Canada?

Canada legalized the non-medical use and supply of cannabis in 2018. The public health-relevant outcomes of cannabis legalization documented to date have been mixed, with decreases in cannabis-related crime and illegal distribution markets, while with increases for many – acute a...

FEEDSETUP: feeding difficulties spectrum evaluation and treatment up-to-date proposal

OBJECTIVE: To organize current knowledge and propose a comprehensive, treatment-focused classification system, called FEDSETUP, that guides clinicians through a stepwise, multidisciplinary approach to pediatric feeding difficulties, emphasizing intervention intensity matched to c...

The above- and below-ground root-to-shoot ratio in urban trees – a ground penetrating radar assessment

Abstract Urban trees are renowned for providing fundamental ecosystem services that stem from their proper development in cities. However, the urban environment poses significant challenges for trees, including impairments from the above- and below-ground grey infrastructure. Imp...

Association of Interleukin‐17F Polymorphisms (rs763780, rs9382084, rs2397084, and rs12203582) With Gastric Cancer Susceptibility According to Helicobacter pylori Infection Status

ABSTRACT Single nucleotide polymorphisms (SNPs) in the interleukin‐17F (IL‐17F) gene may modulate inflammatory responses, with distinct effects on inflammation and tumour progression. Helicobacter pylori infection, a Group 1 carcinogen, is strongly associated with gastric cancer...

Frailty assessed using the Edmonton Frail Scale predicts mortality and waitlist removal for kidney transplant candidates: a prospective study

Frailty is associated with adverse outcomes in kidney transplant (KT) candidates. The Edmonton Frail Scale (EFS) is a reliable tool to access frailty in a multidimensional approach. However, its prognostic association with outcomes in transplant waitlist remains unclear. Hence th...