Tongji University

Centrifugal shaking-table test study on the dynamic responses of rock slope containing weak interlayer reinforced with prestressed composite structure

Abstract Background Rock slopes containing weak interlayers are susceptible to seismic-induced sliding failure along the interlayer planes. This study aims to investigate the dynamic response of prestressed composite structures reinforced rock slopes containing weak interlayers....

Colorectal cancer-derived IGFBP2 promotes liver metastasis by driving intrahepatic fibrotic pre-metastatic niche formation

Colorectal cancer (CRC) liver metastasis (LM) is a leading cause of cancer-related death, with pre-metastatic niche (PMN) formation being critical for metastasis. Insulin-like growth factor binding protein 2 (IGFBP2) is overexpressed in metastatic CRC, but its role in intrahepati...

Real-world evidence of self-managed weight loss enhancing skeletal muscle rate in individuals with overweight/obesity via mHealth app

Weight loss is essential for obesity management but may be compromised by skeletal muscle loss. This study evaluated the increase in skeletal muscle rate (SMR) and fat loss among individuals with overweight/obesity who achieved weight loss through self-management using a mobile h...

Dietary Inflammatory Index, Physical Activity, and Inflammation-Related Health Outcomes: A Narrative Review and Inflammatory Resilience Framework

How physical activity may modify the health consequences of a pro-inflammatory diet remains an important but unresolved question. This hypothesis-generating narrative review examines this question by integrating evidence on dietary inflammatory potential, physical activity, physi...

Arming the living drugs: nanoengineered bacteria for precision tumor theranostics

Bacteria-mediated tumor therapy exploits the innate ability of anaerobic bacteria to selectively colonize hypoxic tumor regions. However, clinical translation of this approach is hindered by three core challenges: insufficient monotherapy efficacy, the inability to non-invasively...

Determinant model of green creative network capability of family farms: An exploration based on grounded theory

: Green Creative Network Capability (GCNC) is particularly important for addressing business-model homogenization and weak sustainability awareness among family farms in China. Existing studies on green creativity and network capability have mainly focused on corporate contexts,...

Anisotropic variable negative-Poisson-ratio metamaterials for tunable multispectral camouflage and electromagnetic energy harvesting

Adaptive electromagnetic compatibility, camouflage, and energy conversion raises challenge in the swiftly responsive modulation. Herein, we designed pixelated negative-Poisson-ratio metamaterials that enable fast control over structural anisotropy and thus electromagnetic propert...

Strength enhancement and microstructural evolutions of dredged slurry stabilized with waste-modified composite binder

Dredged slurry with high water content and low permeability is prone to drainage clogging during vacuum preloading, limiting its direct use in land reclamation and typically requiring cement-based treatment. To explore a lower-carbon alternative to conventional treatment, this st...

The landscape and plasticity of transposable element expression in an adult stem cell of high physiological and clinical significance

Abstract Transposable elements (TEs) contribute to diverse aspects of stem cell biology, particularly in germline and pluripotent stem cells, which typically exhibit more open chromatin. In human adult stem cells (ASCs), however, a comprehensive framework describing the landscape...

Analysis and Considerations to Lessen Visual Clutter: Multidimensional Associations Between Streetscape Visual Clutter and Urban Perceptions in Shanghai

Visual clutter can affect attention, cognitive load, and environmental evaluation, yet streetscape studies often treat visual complexity as a broad construct without distinguishing visual richness from competition among visual features. Shanghai was selected because its dense, he...

Institutional complexity and entrepreneurial work in grassroots cultural heritage: Evidence from Hanfu entrepreneurship in China

Abstract Cultural heritage entrepreneurship (CHE) often requires entrepreneurs to reconcile authenticity claims with commercial imperatives. This challenge is especially pronounced in grassroots heritage revivals where heritage meanings are contested and cultural authority is une...

Artificial intelligence empowers full-stack histopathological diagnosis and prognosis of renal cell tumor: a multi-center study with external validation

BACKGROUND: The rapid advancement of digital pathology has opened unprecedented opportunities for intelligent diagnosis in renal cell tumor. However, there remains a significant gap in the availability of reliable deep learning models capable of comprehensive kidney cancer detect...

Leveraging Deep Reinforcement Learning to Facilitate the Transition from Knowledge Diversity to Knowledge Creation in Construction Project Teams

Abstract Knowledge diversity is essential for innovation in construction project teams, yet translating it into tangible outcomes remains challenging. Traditional management theories and static methods often fail to provide dynamic solutions. This study addresses the issue throug...

Wingtip Vortex Statistics and Multiscale Evolution in Grid-Generated Turbulent Flow

Freestream turbulence (FST) exerts a pronounced influence on the evolution of wingtip vortices through interactions between multiscale vortex structures. In this study, the vortex statistics and multiscale dynamics of an isolated wingtip vortex subjected to three levels of FST ar...

BCL9 inhibition promotes fibroblast lipogenesis by regulating macrophage–fibroblast interactions to attenuate pulmonary fibrosis

Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal interstitial lung disease with an urgent need for novel therapeutic strategies. M2 macrophage-derived TGF-β1 promotes fibroblast myogenesis, contributing to IPF pathogenesis. Targeting macrophage polarization and fibr...

Conformal principal-asymptotic nets: Parametric design and modular construction of elastic gridshells

Current modular design approaches often rely on numerical optimization to satisfy fabrication constraints, which can be computationally intensive and sensitive to initial geometric conditions. This work introduces a parametric design algorithm based on Conformal Principal-Asympto...

Detailed study of non-equilibrium characteristics of quasi-neutral TNSA plasmas

In an experiment performed in November 2022 at the petawatt (PW) laser facility at Vega III located in Salamanca-Spain, we have studied the successful production of several radioisotopes using protons accelerated by the Target Normal Sheath Acceleration (TNSA) mechanism (Rodrigue...

Smart Urban Agriculture in Transition: A Systematic Review of ICT Integration, Applications, and Challenges

This paper systematically reviews the emerging field of smart urban agriculture, defined as the integration of information and communication technologies (ICTs) into food production practices within and around built-up urban areas. Although urban agriculture and digital agricultu...

Layered double hydroxide-based ROS-scavenging nanozyme hydrogels re-establish osteoimmune-angiogenic coupling for osteoporotic bone repair

Abstract Background Osteoporotic bone defects (OP-BDs) present a significant clinical challenge because of a pathological microenvironment characterized by severe oxidative stress, persistent inflammation, and disrupted metabolic coupling between osteoblasts and osteoclasts. To o...

Structure-based design of peptide inhibitors targeting the SPSB2–iNOS interaction: a computational approach to modulating nitric oxide signaling

Dysregulation of inducible nitric oxide synthase (iNOS) plays a central role in inflammatory diseases, cancer, and neurodegeneration due to excessive nitric oxide (NO) production. Suppressor of Cytokine Signaling Box Protein 2 (SPSB2) is a key negative regulator of iNOS through s...