Tongji University

Mefatinib versus gefitinib as a first-line treatment for EGFR-mutated non-small cell lung cancer: a randomized, double-blind, multicenter phase III study

Mefatinib, a novel second-generation epidermal growth factor (EGFR) tyrosine kinase inhibitor that has shown promising antitumor activity in targeting non-small cell lung cancer (NSCLC) with common and uncommon EGFR- activating mutations. In this phase III, randomized, double-bli...

Integrated Risk Assessment of Landfill Flowslides: Sensitivity Analysis of the Initiation Mechanism and Hazard Potential

Abstract Numerous landfill flowslide disasters have occurred globally, posing a significant threat to the environment and human lives and property. The progressive evolution of flowslides, encompassing both the slope failure and postfailure motion stages, is influenced by waste p...

Photoinduced Switching-onof Intermolecular FerromagneticExchange in a Cobalt–Viologen Donor–Acceptor Assembly

Abstract Crystal engineering of anisotropic molecular solids that translate photoinduced charge transfer into switchable magnetic exchange offers a route to optically addressable exchange-correlated magnetic states. Here, we show that (MV)[Co(pdms)2](MeOH)2(MeCN), a donor–accepto...

Non-Linear Impacts and Spatial Variations in Multidimensional Built Environments on E-Shopping Decisions: Evidence from Shanghai

While e-commerce has transformed consumption patterns, online shopping behavior remains influenced by the physical environment. Using Shanghai as a case study, this research applies machine learning, SHAP analysis, and K-Means clustering to examine the nonlinear impacts and spati...

Metal–OrganicFrameworks (MOFs) for the Deliveryof Small-Molecule Therapeutics

Abstract As cutting-edge porous materials, the properties of metal–organic frameworks (MOFs) are governed by their metal nodes and organic linkers, as well as the assembly mode of these subunits. This allows the loading capacity of MOFs for small-molecule drugs to be readily tail...

Visual Branding and the Politics of Gentrification: Barcelona through Three Urban Mirrors

When I first arrived in Barcelona, the city seemed unusually aware of its own image. Its pavements, façades, monuments, shopfronts, housing photographs, and museum narratives form a visual system that makes the city easy to recognise and consume. This essay asks what that system...

Visual Branding and the Politics of Gentrification: Barcelona through Three Urban Mirrors

When I first arrived in Barcelona, the city seemed unusually aware of its own image. Its pavements, façades, monuments, shopfronts, housing photographs, and museum narratives form a visual system that makes the city easy to recognise and consume. This essay asks what that system...

Elastic modulus recovery in concrete incorporating biomimetically mineralized recycled aggregates

Abstract The structural application of recycled aggregate concrete (RAC) is severely hindered by its low elastic modulus, primarily caused by porous adhered mortar and defective interfacial transition zone (ITZ). This study proposes a novel biomimetic mineralization strategy to c...

MXene-Based Conductive Microneedle Patch Promotes Diabetic Wound Healing by Regulating Oxidative Stress and Immune Microenvironment

Abstract Excessive reactive oxygen species (ROS) generation and the release of inflammatory mediators create a pathological microenvironment in diabetic wounds, severely impairing the healing process. Coupling endogenous electric fields has shown great therapeutic potential for i...

Targeting the ANKRD54/ELOVL6 axis suppresses malignancy in BRAF mutant colorectal cancer by disrupting fatty acid metabolism and promoting ferroptosis

Abstract Background BRAF-mutant (BRAF-MT) colorectal cancer (CRC) represents a clinically aggressive subtype characterized by distinct biological features and significantly worse prognosis compared to BRAF wild-type (BRAF-WT) CRC, with median survival reduced by approximately 40%...

Monolithic AgX/Biomass Carbon Aerogels (X = Br, Cl) for Recyclable Photocatalytic Degradation of Multiple Pollutant Classes

While silver halides (AgX) are promising visible-light photocatalysts for water remediation, their practical deployment is severely hindered by intrinsic photocorrosion, rapid charge recombination, and macroscopic recovery challenges. Here, we demonstrate a monolithic AgX/biomass...

Chemotherapy remains effective in ALK-TKI therapy: a retrospective analysis in ALK-positive advanced NSCLC

Tyrosine kinase inhibitors (TKIs) are the standard therapy for advanced non-small cell lung cancer (NSCLC) harboring anaplastic lymphoma kinase (ALK) fusions. However, acquired resistance remains a major challenge, necessitating strategies to prolong therapeutic efficacy. This st...

Centrifugal shaking-table test study on the dynamic responses of rock slope containing weak interlayer reinforced with prestressed composite structure

Abstract Background Rock slopes containing weak interlayers are susceptible to seismic-induced sliding failure along the interlayer planes. This study aims to investigate the dynamic response of prestressed composite structures reinforced rock slopes containing weak interlayers....

Colorectal cancer-derived IGFBP2 promotes liver metastasis by driving intrahepatic fibrotic pre-metastatic niche formation

Colorectal cancer (CRC) liver metastasis (LM) is a leading cause of cancer-related death, with pre-metastatic niche (PMN) formation being critical for metastasis. Insulin-like growth factor binding protein 2 (IGFBP2) is overexpressed in metastatic CRC, but its role in intrahepati...

Real-world evidence of self-managed weight loss enhancing skeletal muscle rate in individuals with overweight/obesity via mHealth app

Weight loss is essential for obesity management but may be compromised by skeletal muscle loss. This study evaluated the increase in skeletal muscle rate (SMR) and fat loss among individuals with overweight/obesity who achieved weight loss through self-management using a mobile h...

Determinant model of green creative network capability of family farms: An exploration based on grounded theory

: Green Creative Network Capability (GCNC) is particularly important for addressing business-model homogenization and weak sustainability awareness among family farms in China. Existing studies on green creativity and network capability have mainly focused on corporate contexts,...

Arming the living drugs: nanoengineered bacteria for precision tumor theranostics

Bacteria-mediated tumor therapy exploits the innate ability of anaerobic bacteria to selectively colonize hypoxic tumor regions. However, clinical translation of this approach is hindered by three core challenges: insufficient monotherapy efficacy, the inability to non-invasively...

Dietary Inflammatory Index, Physical Activity, and Inflammation-Related Health Outcomes: A Narrative Review and Inflammatory Resilience Framework

How physical activity may modify the health consequences of a pro-inflammatory diet remains an important but unresolved question. This hypothesis-generating narrative review examines this question by integrating evidence on dietary inflammatory potential, physical activity, physi...

Strength enhancement and microstructural evolutions of dredged slurry stabilized with waste-modified composite binder

Dredged slurry with high water content and low permeability is prone to drainage clogging during vacuum preloading, limiting its direct use in land reclamation and typically requiring cement-based treatment. To explore a lower-carbon alternative to conventional treatment, this st...

Anisotropic variable negative-Poisson-ratio metamaterials for tunable multispectral camouflage and electromagnetic energy harvesting

Adaptive electromagnetic compatibility, camouflage, and energy conversion raises challenge in the swiftly responsive modulation. Herein, we designed pixelated negative-Poisson-ratio metamaterials that enable fast control over structural anisotropy and thus electromagnetic propert...