Tokyo University of Agriculture and Technology

Inhibitory Activity on Dog Bladder Cancer Organoids by Lanostane-type Triterpenes from Inonotus obliquus and Reinvestigation of Their NMR Assignments

Abstract Dog bladder cancer organoids (DBCO) serve as a model of human muscle-invasive bladder cancer (MIBC), for which suitable human organoid models remain limited. Inonotus obliquus (Chaga) extract reportedly reduces DBCO growth, but its active constituents were unidentified....

Concurrent fibrinogen Aα-chain amyloidosis and AA amyloidosis in a Humboldt penguin (Spheniscus humboldti)

Abstract Amyloidosis is a disease characterized by the deposition of abnormally folded proteins as amyloid fibrils in tissues and occurs in various mammals and birds. In some cases, amyloids derived from two different precursor proteins may coexist in the same individual, a condi...

Steam reforming of acetic acid over Ni nanoparticle catalysts encapsulated on Al2O3 using cellulose nanofibers (CNFs) as a template: the role of promoter addition

A novel cellulose nanofiber (CNFs)-templated Ni-Al 2 O 3 catalyst was developed to enable efficient steam reforming of bio-oil aqueous-phase components. CNFs derived from sustainable pulp feedstock served as sacrificial structural templates, promoting hierarchical porosity and im...

Spatial, Histochemical, and Ultrastructural Analysis of Melanomacrophages in the Liver of the Red‐Eared Slider ( Trachemys scripta elegans )

ABSTRACT Melanomacrophages (MMs) are pigmented phagocytic cells observed in ectotherms. Investigating MMs is valuable for elucidating the evolutionary background of the vertebrate immune system. However, studies regarding the distribution and function of hepatic MMs remain limite...

Characterization of variability of water and nutrient cycles in small floodplain water bodies using a geochemical multi-tracer

River floodplains contribute to river ecosystems by supporting high biological productivity and biodiversity. Backwaters, locally called Wando in Japanese, are semi-enclosed water bodies formed along rivers that serve as habitats for aquatic organisms. However, research on the or...

Fusarium oxysporum f. sp. crypti , a novel forma specialis causing Fusarium wilt of mitsuba, Cryptotaenia japonica

Fusarium oxysporum isolates causing Fusarium wilt in mitsuba (Cryptotaenia japonica Hassk.; also referred to as Japanese honeywort, Japanese honewort, or Japanese parsley) have traditionally been classified as f. sp. apii. However, some reports have indicated that the host-pathog...

Oxidative Fluorination of β-Ketoamides: Guanidinium Iodides as Iodoarene Alternatives

Abstract A guanidinium iodide-catalyzed oxidative fluorination of β-ketoamides enables umpolung α-fluorination, replacing iodoarenes with a simple iodide source. Using HF·pyridine as the fluoride source and mCPBA as the oxidant in dichloroethane, quaternary α-fluoro-β-ketoamides...

Phonon mean free path and thermal conductivity in grain size- and shape-controlled polycrystalline nanostructures via Laguerre tessellation

We systematically investigate the effects of grain size and sphericity distributions on phonon mean free path and thermal conductivity using phonon transport simulations. Polycrystalline nanostructures are generated via Laguerre tessellation, enabling independent control of grain...

Photocatalytic Conversion of Glucose to Organic Peroxides via Pd/WO3

Abstract Conversion of biomass-derived materials into sustainable chemical feedstocks represents a critical research challenge that has attracted global attention. In this study, we have successfully developed a novel photocatalytic system that generates organic peroxides from gl...

Carbonate-Based Crosslinked Composite Electrolytes Reinforced with Silica Nanofiber Membrane

Abstract A crosslinked carbonate-based composite electrolyte incorporating an electrospun silica nanofiber (SNF) membrane was developed for Li batteries. Compared with the SPE, the resulting SNF-CPE exhibited higher ionic conductivity and improved mechanical properties. The Li|SN...

Microdroplet-based high-throughput screening for antagonistic bacteria targeting penaeid shrimp pathogenic Vibrio harveyi

Antagonistic bacteria that suppress the growth of specific bacteria have attracted attention as an antibiotics-independent strategy for infectious disease control in aquaculture. Microfluidics-based water-in-oil droplets (microdroplets) enable high-throughput screening of antagon...

Modeling Canine Hemangiosarcoma Progression Using Patient-Derived 2.5D Organoids and Orthotopic Xenografts

Canine hemangiosarcoma (HSA) is a highly aggressive vascular malignancy encountered in veterinary practice and exhibits histopathological and molecular similarities to human angiosarcoma (AS). Despite its clinical importance, the molecular mechanisms driving canine HSA remain poo...

Housing environments link egg taste through metabolic alterations in laying hens

Farm animal welfare is increasingly recognized as a core component in sustainable protein production. The transition to welfare-friendly housing systems—such as from cage to cage-free systems for laying hens—promotes the expression of motivated behaviors by providing greater spac...

Redox-network reconfiguration inferred from the ln [O 2 ]– E h relationship under mixed-potential conditions in a shallow pond time series

Abstract. Oxidation–reduction potential (Eh) is widely used as an in situ indicator of redox conditions in aquatic environments, and field electrodes typically record a mixed potential generated by multiple concurrent interfacial redox reactions. Beyond a simple Nernstian interpr...

Age-Related Behavioral Changes Across the Adult Lifespan of a Cricket: A Longitudinal Analysis Using DeepLabCut

<title>Abstract</title> Aging in insects is characterized by progressive behavioral changes, including declines in locomotion, altered sleep, and disrupted circadian rhythms. The two-spotted cricket ( <italic>Gryllus bimaculatus</italic> ) is a useful model for behavioral senesce...

Social system and spatial behavior drive interspecific differences in foraging intensity and plant-level damage in sympatric ungulates

Foraging behavior in ungulates affects not only their own fitness but also the fitness and morphology of the plants they consume. While intraspecific variation in ungulate foraging behavior has been extensively studied, interspecific differences—particularly those associated with...

A Programmable Nanovesicle Platform for MegapascalPressure Sensing

Abstract Hydrostatic pressure (HP) is a subtle yet pervasive force that shapes chemistry and biology from the ocean floor to living cells─yet real-time HP sensing at the microscale remains elusive. Here, we report pyrene-modified polyionic complex vesicles (Pyr-PICsomes) as a cla...

Genome analysis of the glycosphingolipid-producing green alga Tetraselmis sp. NKG400013

Abstract Microalgae are gaining attention as sustainable resources for the production of valuable compounds, including biofuels, pigments, and bioactive metabolites. To support metabolic engineering and genome editing approaches aimed at enhancing these traits, high-quality genom...

“Grafting-From” Synthesis of Cellulose Acetate-graft-Poly(propylene carbonate) and Evaluation of Its Physical Properties

Poly(propylene carbonate) (PPC) is synthesized through the alternating copolymerization of propylene oxide (PO) and carbon dioxide (CO2) and has been widely studied as a sustainable polymer material. Although PPC is known for its biodegradability, biocompatibility, high optical t...

Impulse-induced liquid jets from bubbles with arbitrary contact angles

This paper investigates the relationship between the contact angle of a spherical bubble attached to a tube submerged in a container and the jet speed induced by an impulsive acceleration at its base. While it has been well established that bubble geometry strongly influences the...