Tianjin Medical University

Clinical and neural effects of a hybrid accelerated–maintenance iTBS protocol in adolescents with major depressive disorder

Intermittent theta burst stimulation (iTBS) has emerged as a safe and effective intervention for adolescents with major depressive disorder (MDD). While accelerated iTBS can induce rapid clinical improvement, intensive multi-day treatment schedules may present practical challenge...

Blue Light Pollution and Ocular Surface Toxicity: p53-Mediated Ferroptosis in Corneal Epithelium Drives Dry Eye Pathogenesis

Purpose: This study investigated the molecular mechanisms underlying blue light-induced corneal epithelial toxicity. Methods: C57BL/6J mice were exposed to 460 nm blue light for 1, 2, or 4 weeks, whereas human corneal epithelial (HCE) cells were exposed for 15 or 30 min. RNA-sequ...

Prognostic significance of adropin with Grace and Gensini scores for in-hospital outcomes in ST: elevation myocardial infarction patients

This prospective cohort study investigated the prognostic value of serum Adropin in patients with ST-segment elevation myocardial infarction (STEMI) and its incremental predictive utility beyond traditional GRACE and Gensini scores. A total of 508 participants were enrolled, incl...

Ambient nitrogen dioxide and composition-specific risk of urolithiasis: a multicenter time-stratified case-crossover study

Background: Emerging evidence suggests that ambient air pollution and meteorological variation may trigger urolithiasis, but stone-composition–specific and lagged associations are poorly characterized.Methods: We conducted a multicenter, time-stratified case-crossover study in Gu...

Multiple-adverse health conditions, mental health, and health-related quality of life in stroke survivors: Latent profile analysis and mediation analysis

Objective This study aimed to identify subgroups of stroke survivors based on multiple-adverse health conditions and determine the potential mediation effects of mental health in their relationship with health-related quality of life. Design A cross-sectional study. Setting Three...

Prediction Method of Residual Electrical Life of Air Circuit Breakers Based on Mechanical Parameters

Air circuit breakers are critical protective devices in low-voltage distribution systems, and their reliability is considered to have significant influence on the operation of such systems. With respect to the electrical performance degradation of air circuit breakers, the relati...

Validation of the “purfling sign” for differentiating primary central nervous system lymphoma from high-grade glioma: a retrospective multicenter cohort study

Abstract Background The study aimed to evaluate whether the imaging marker “purfling sign” can reliably distinguish primary central nervous system lymphoma (PCNSL) from high-grade glioma and systematically assess its diagnostic performance, differential utility and clinical value...

Atomically Precise Pt 3 Cu 2 Clusters Restore Energy Metabolism via Targeted Succinate Degradation

ABSTRACT Succinate is a critical intermediate for the tricarboxylic acid cycle, whose abnormal accumulation can disrupt energy homeostasis and trigger systemic inflammatory injury across dominant metabolic organs. Targeting succinate thus represents a pivotal strategy to reestabl...

Intraplaque Hemorrhage in Chronic Anterior Circulation Arterial Occlusion: Associated Factors and Vessel‐Specific Patterns on High‐Resolution Magnetic Resonance Imaging

Background Chronic anterior circulation arterial occlusion, particularly involving the internal carotid artery or middle cerebral artery (MCA), carries a persistent risk of ischemic events. Intraplaque hemorrhage (IPH) is a marker of plaque instability, but its prevalence, vessel...

Chidamide plus venetoclax as effective and safe maintenance therapy in high-risk acute myeloid leukemia and myelodysplastic syndrome post-transplantation

Abstract Relapse after allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains the leading cause of treatment failure in high-risk acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS), yet effective maintenance strategies are currently lacking. The combi...

Ambient cold exposure and myocardial infarction risk in Tianjin, China: a distributed lag non-linear analysis

Abstract Background Ambient temperature is an important environmental determinant of cardiovascular health. Although cold exposure has been associated with acute myocardial infarction (MI), evidence on delayed effects and subtype-specific differences remains limited in northern C...

Exosomes in brain diseases: Mechanisms, advances, and perspectives

The blood–brain barrier (BBB) remains a major biological obstacle limiting the effective delivery of therapeutics for central nervous system (CNS) disorders. Although conventional drug delivery approaches have achieved continuous advances, their clinical translation is frequently...

Spatiotemporal-switchable 2D NIR-II single-atom nanozyme for single-cell–level surgical navigation and glioblastoma phototherapy

Single-cell–level resolution tumor therapy represents an advanced strategy against glioblastoma but lacks suitable theranostic agents. Here, we developed a spatiotemporal-switchable, two-dimensional (2D), bismuthene-based second near-infrared window (NIR-II) nanozyme. In this pla...

Selective compartmental plication in small-angle convergence insufficiency exotropia: surgical outcomes and predictive model

This study aimed to evaluate a novel surgical approach combining unilateral lateral rectus recession (LRc) with compartmentalized inferior medial rectus plication (CIMRP) for treating small-angle (< 25 prism diopters, PD) convergence insufficiency intermittent exotropia (CI-IXT)...

Impact of Multidisciplinary Integrated Rehabilitation on ICU-Acquired Weakness in Critically Ill Patients: A Prospective Cohort Study on Clinical Efficacy, Functional Recovery, and Correlation Analysis

Background ICU-acquired weakness (ICU-AW) affects 25%–65% of critically ill patients, prolonging ventilation and hospitalization, impairing quality of life, and increasing mortality. Objective To assess MIR's effect on ICU-AW, functional recovery, and links to clinical, inflammat...

Risk factors for incident chronic kidney disease following unilateral nephrectomy: a systematic review and meta-analysis

Nephrectomy is standard for kidney tumors and living kidney donation, but postoperative chronic kidney disease (CKD) is a critical determinant of long-term outcomes. Risk factors for incident CKD after unilateral nephrectomy remain incompletely synthesized. PubMed, Embase, Web of...

Third-party governance and artificial intelligence for diabetes management in primary health care, China.

Problem: Fragmented primary health care in China fails to tackle the growing burden of noncommunicable diseases. Despite substantial investment, fewer than half of patients with diabetes achieve glycaemic control. Approach: Tianjin's 2020-2023 reform established a public-private...

Deep learning-based analysis of paraspinal muscle changes in lumbar disc herniation

Lumbar disc herniation (LDH) is a predominant cause of low back pain, significantly affecting the quality of life of patients and closely linked to the condition of paraspinal muscles (PSM). However, existing two-dimensional (2D) measurement techniques that rely on muscle cross-s...