Tianjin Medical University

Predictive value of maternal serum occludin for neonatal respiratory distress syndrome in spontaneous preterm birth

OBJECTIVE: This study investigates maternal serum occludin and human leukocyte antigen G (HLA-G) profiles across preterm birth subtypes and their predictive value for neonatal respiratory distress syndrome (NRDS). METHODS: This retrospective analysis was conducted at Tianjin Cent...

Effect of electroacupuncture on postoperative delirium in older patients undergoing major surgery: a prospective, multicenter, randomized sham-controlled trial

Abstract Purpose Postoperative delirium (POD) is a common complication in older patients undergoing major surgery and is associated with prolonged hospitalization, delayed recovery, and increased mortality. This study evaluated whether perioperative electroacupuncture (EA) reduce...

Features and a specific pattern of cerebral perfusion in patients with Lewy body dementia: Diagnostic ability and clinical correlations

Cerebral perfusion changes have been observed in patients with both dementia with Lewy bodies and Parkinson’s disease dementia. In this study, features of cerebral blood flow (CBF) and a specific perfusion pattern measured using arterial spin labeling (ASL) MRI for Lewy body deme...

Estradiol Promotes Tumor Progression in ERα‐Low Endometrial Cancer via the GPER/SphK1 Pathway

ABSTRACT Endometrial cancer (EC) is the most common gynecological malignancy in postmenopausal women. Patients with low estrogen receptor alpha (ERα) expression frequently develop aggressive pathological subtypes and have poor prognosis. The role of estradiol (E2) in ERα‐low EC r...

Diagnostic accuracy and prognostic value of lncRNA H19 in gastric cancer: a systematic review and meta-analysis

Abstract Background LncRNA H19 is upregulated considerably in gastric cancer and participates in its apoptosis, proliferation, migration, invasion, and metastasis. The objective of this meta-analysis is to demonstrate its diagnostic and prognostic values for gastric cancer. Metho...

Impact of oculorespiratory reflex on postoperative recovery following pediatric strabismus surgery: a retrospective cohort study

The Oculorespiratory Reflex (ORR) is a common intraoperative reflex observed in pediatric patients undergoing strabismus surgery. Despite its prevalence, the potential association between ORR and postoperative complications has not been thoroughly investigated. This retrospective...

Texture similarity network uncover schizophrenia subtypes with unique molecular signatures

Abstract Schizophrenia manifests complex heterogeneity across multiple dimensions, posing major challenges for precise diagnosis and treatment. Developing objective biomarkers to stratify patients into stable subtypes is essential for heterogeneity resolving and precision medicin...

Cardiac Electro-structural Remodeling and Arrhythmia Risks Across the Spectrum of Obesity Defined by the New Lancet framework

Abstract Background Obesity is linked to higher arrhythmia risk, yet BMI overlooks its complexity. Recently, the Lancet Commission has introduced a new obesity framework. We aimed to compare arrhythmia risks across distinct obesity categories. Methods Participants from the UK Bio...

Association between low-level geometric features of central gaze-guiding patterns and SSVEP responses in mixed reality head-mounted display environments

This study investigated the correlation between the low-order geometric properties of centrally fixated guide patterns and steady-state visual evoked potential (SSVEP) responses in a mixed reality (MR) head-mounted display environment. An MR-SSVEP experimental environment was est...

Early transmission risks of Ebola disease outbreak caused by Bundibugyo virus in the Democratic Republic of the Congo

An outbreak of Ebola disease caused by Bundibugyo virus (BDBV) has been ongoing since April 2026, primarily in the Democratic Republic of the Congo. We estimated the initial reproduction number of BDBV at 1.85 (95% CrI: 1.09, 3.25), underscoring the urgent need for timely impleme...

SelO functions as a tumor suppressor through AMPylating Cdk5rap3

Cell fate is governed by signaling pathways involving diverse protein modifications. However, how protein AMPylation mediates signal transduction in mammalian cells remains largely unexplored. We demonstrate that the protein adenylyltransferase, SELENOO (SelO), is induced by chem...

Analysis of risk factors and construction of a nomogram prediction model for early hemoptysis following 125I seed implantation in patients with advanced lung cancer

PURPOSE: I) seed implantation in patients with advanced lung cancer and to develop a nomogram-based prediction model. METHODS: I seed implantation at the Second Hospital of Tianjin Medical University between August 2023 and May 2025. Patients were divided into a hemoptysis group...

Beyond passive mixing: Geometric evolution and multifunctional applications of staggered herringbone microfluidic devices

Staggered herringbone microfluidic chips are widely used passive systems for enhancing transport and interaction under laminar flow conditions, and have been extensively applied in chemical synthesis, biosensing, and cell-related studies. The performance of these systems is funda...

Novel mutations of PIKFYVE identified in 322 sporadic cataract patients

BACKGROUND: PIKFYVE, a novel pathogenic gene causing congenital cataract, its association with sporadic cataracts has not been systematically investigated. This study aimed to explore PIKFYVE mutation profiles in major sporadic cataract subtypes. METHODS: We enrolled 322 sporadic...

The abscopal effect and systemic immune reprogramming: from phenomenon to therapeutic design

The classical abscopal effect is defined here as objective regression of a verified non-irradiated tumor lesion following local radiotherapy. An immune abscopal phenomenon denotes a prespecified, reproducible immune change within such a lesion that is attributable to the local in...

Phys-AbGAT: A Physics-Informed Multi-Task Graph Attention Network for Robust Antibody-Antigen Binding Affinity Prediction

Abstract Motivation Accurate prediction of antibody-antigen binding affinity is essential for therapeutic antibody design. Existing methods often model the dissociation constant (KD) and Gibbs free energy (ΔG) independently, overlooking their thermodynamic relationship and comple...

5C psychological antecedents of vaccine hesitancy toward maternal RSV vaccines and infant monoclonal antibodies among pregnant and postpartum women and their partners in China: A multicenter, dyadic survey design, cross-sectional study

We assessed vaccine hesitancy toward two novel respiratory syncytial virus (RSV) immunization strategies, maternal vaccines and infant monoclonal antibodies (mAbs), among 4422 couples across eight Chinese provinces, via a multicenter cross-sectional survey with convenience sampli...

Whole exome sequencing and cluster analysis reveal that EPB41L4A mutation may trigger tooth agenesis

Objective To detect and analyze the correlation between commonly mutated genes and known genes associated with tooth agenesis in patients with non-syndromic tooth agenesis. The aim is to explore new genes that may be associated with tooth agenesis, to provide a genetic reference...

Comprehensive Evaluation and Explainable Interpretation of Peptide-HLA Binding Prediction Tools

Abstract Accurate prediction of peptide binding to human leukocyte antigen class I (HLA-I) molecules is critical for advancing immunological research, particularly in vaccine design and immunotherapy. However, limitations in model performance, interpretability, and dataset qualit...

Distal-first versus proximal-first laparoscopic nephroureterectomy for non-muscle-invasive upper tract urothelial carcinoma: a retrospective cohort study

Abstract Background and objective The optimal sequence of ureteral and vascular control during laparoscopic nephroureterectomy (LNU) for non-muscle-invasive (≤ pT1) upper tract urothelial carcinoma (UTUC) remains controversial. We compared distal-first (initial ureteral ligation)...