Tianjin Medical University

Spliceosome gene mutations synergize with anthracyclines to amplify atrial fibrillation risk in hematologic malignancies: a multicenter cohort study with discovery and validation

Abstract Background Atrial fibrillation (AF) is a life‑threatening complication in patients with hematologic malignancies, yet personalized risk stratification remains challenging. Spliceosome gene mutations are key drivers of these malignancies, but their specific role in AF pat...

Multicenter Privacy‐Preserving Federated Models for Predicting Postoperative Delirium and Acute Kidney Injury in Older Patients

ABSTRACT Postoperative delirium (POD) and acute kidney injury (AKI) are serious complications in older patients undergoing surgery, yet predictive model development is often constrained by single‐center data limitations and privacy concerns that preclude centralized data sharing....

NEK2-AURKA axis drives ubiquitin-dependent IFT88 degradation to suppress ciliogenesis and promote basal-type bladder cancer

Abstract Loss of primary cilia is common in cancer, but its relevance to molecular subtypes of muscle-invasive bladder cancer (MIBC) is unclear. Here, we combined transcriptomic and co-expression analyses with experiments in bladder cancer cell lines, human tumor specimens, and x...

Phase Separation of TRIM21 Modulates PTPN14 Stability to Drive Flow‐Dependent Endothelial Activation and Atherogenesis

Local flow patterns determine the uneven distribution of atherosclerotic lesions, yet the underlying mechanism remains poorly defined. We previously reported that protein tyrosine phosphatase nonreceptor type 14 (PTPN14) is implicated in atherosclerosis. Its role in flow-dependen...

Fine-tuning an ECG foundation model to predict coronary CT angiography outcomes

<title>Abstract</title> Coronary artery disease (CAD) remains a major global health burden. Accurate identification of the culprit vessel and assessment of stenosis severity are essential for guiding individualized therapy. Although coronary CT angiography (CCTA) is the first-lin...

Association of pre-clinical depressive symptoms and its plasma metabolomic signature with Parkinson’s disease: a community-based longitudinal study

Abstract Accumulating evidence has suggested that depression is associated with an increased risk of Parkinson’s disease (PD), yet whether pre-clinical depressive symptoms in PD development and the potential mediating effects of metabolomic profiles remain unclear. We aimed to ex...

Clinical and neural effects of a hybrid accelerated–maintenance iTBS protocol in adolescents with major depressive disorder

Intermittent theta burst stimulation (iTBS) has emerged as a safe and effective intervention for adolescents with major depressive disorder (MDD). While accelerated iTBS can induce rapid clinical improvement, intensive multi-day treatment schedules may present practical challenge...

Prognostic significance of adropin with Grace and Gensini scores for in-hospital outcomes in ST: elevation myocardial infarction patients

This prospective cohort study investigated the prognostic value of serum Adropin in patients with ST-segment elevation myocardial infarction (STEMI) and its incremental predictive utility beyond traditional GRACE and Gensini scores. A total of 508 participants were enrolled, incl...

Blue Light Pollution and Ocular Surface Toxicity: p53-Mediated Ferroptosis in Corneal Epithelium Drives Dry Eye Pathogenesis

Purpose: This study investigated the molecular mechanisms underlying blue light-induced corneal epithelial toxicity. Methods: C57BL/6J mice were exposed to 460 nm blue light for 1, 2, or 4 weeks, whereas human corneal epithelial (HCE) cells were exposed for 15 or 30 min. RNA-sequ...

Multiple-adverse health conditions, mental health, and health-related quality of life in stroke survivors: Latent profile analysis and mediation analysis

Objective This study aimed to identify subgroups of stroke survivors based on multiple-adverse health conditions and determine the potential mediation effects of mental health in their relationship with health-related quality of life. Design A cross-sectional study. Setting Three...

Ambient nitrogen dioxide and composition-specific risk of urolithiasis: a multicenter time-stratified case-crossover study

Background: Emerging evidence suggests that ambient air pollution and meteorological variation may trigger urolithiasis, but stone-composition–specific and lagged associations are poorly characterized.Methods: We conducted a multicenter, time-stratified case-crossover study in Gu...

Prediction Method of Residual Electrical Life of Air Circuit Breakers Based on Mechanical Parameters

Air circuit breakers are critical protective devices in low-voltage distribution systems, and their reliability is considered to have significant influence on the operation of such systems. With respect to the electrical performance degradation of air circuit breakers, the relati...

Validation of the “purfling sign” for differentiating primary central nervous system lymphoma from high-grade glioma: a retrospective multicenter cohort study

Abstract Background The study aimed to evaluate whether the imaging marker “purfling sign” can reliably distinguish primary central nervous system lymphoma (PCNSL) from high-grade glioma and systematically assess its diagnostic performance, differential utility and clinical value...

Atomically Precise Pt 3 Cu 2 Clusters Restore Energy Metabolism via Targeted Succinate Degradation

ABSTRACT Succinate is a critical intermediate for the tricarboxylic acid cycle, whose abnormal accumulation can disrupt energy homeostasis and trigger systemic inflammatory injury across dominant metabolic organs. Targeting succinate thus represents a pivotal strategy to reestabl...

Ambient cold exposure and myocardial infarction risk in Tianjin, China: a distributed lag non-linear analysis

Abstract Background Ambient temperature is an important environmental determinant of cardiovascular health. Although cold exposure has been associated with acute myocardial infarction (MI), evidence on delayed effects and subtype-specific differences remains limited in northern C...

Chidamide plus venetoclax as effective and safe maintenance therapy in high-risk acute myeloid leukemia and myelodysplastic syndrome post-transplantation

Abstract Relapse after allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains the leading cause of treatment failure in high-risk acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS), yet effective maintenance strategies are currently lacking. The combi...

Intraplaque Hemorrhage in Chronic Anterior Circulation Arterial Occlusion: Associated Factors and Vessel‐Specific Patterns on High‐Resolution Magnetic Resonance Imaging

Background Chronic anterior circulation arterial occlusion, particularly involving the internal carotid artery or middle cerebral artery (MCA), carries a persistent risk of ischemic events. Intraplaque hemorrhage (IPH) is a marker of plaque instability, but its prevalence, vessel...

Spatiotemporal-switchable 2D NIR-II single-atom nanozyme for single-cell–level surgical navigation and glioblastoma phototherapy

Single-cell–level resolution tumor therapy represents an advanced strategy against glioblastoma but lacks suitable theranostic agents. Here, we developed a spatiotemporal-switchable, two-dimensional (2D), bismuthene-based second near-infrared window (NIR-II) nanozyme. In this pla...

Exosomes in brain diseases: Mechanisms, advances, and perspectives

The blood–brain barrier (BBB) remains a major biological obstacle limiting the effective delivery of therapeutics for central nervous system (CNS) disorders. Although conventional drug delivery approaches have achieved continuous advances, their clinical translation is frequently...

Impact of Multidisciplinary Integrated Rehabilitation on ICU-Acquired Weakness in Critically Ill Patients: A Prospective Cohort Study on Clinical Efficacy, Functional Recovery, and Correlation Analysis

Background ICU-acquired weakness (ICU-AW) affects 25%–65% of critically ill patients, prolonging ventilation and hospitalization, impairing quality of life, and increasing mortality. Objective To assess MIR's effect on ICU-AW, functional recovery, and links to clinical, inflammat...