The University of Texas at San Antonio Health Science Center

Alcohol reshapes liver zonal plasticity and immune-metabolic reprogramming in metabolic-syndrome associated hepatocellular carcinoma

Hepatocellular carcinoma (HCC) commonly arises in metabolic dysfunction-associated steatohepatitis (MASH), alcohol-related liver disease (ALD), and metabolic dysfunction-associated ALD (MetALD), yet how zonal metabolic programs govern tumor lineage and immune responses remains un...

Fire-Smoke InducedProtein Alterations in Firefighters'Body Fluids Identify Prognostic Pan-cancer Biomarkers

Abstract Firefighters are routinely exposed to complex mixtures of toxicants during fire suppression, and growing evidence links these exposures to elevated cancer risk. Proteomic profiling provides a sensitive means to detect early molecular alterations associated with such occu...

National Trends, Postoperative Antibiotic Utilization, and Complications Following Operative Management of Mandibular Condylar Fractures: A TriNetX Database Review

BACKGROUND: Debate persists regarding the management of condylar fractures. While systematic reviews and retrospective studies have examined clinical outcomes, national complication profiles, and postoperative antibiotic utilization remain incompletely characterized. METHODS: The...

Serotonin Transporterand Organic Cation Transporter3 Contribute to Basolateral Amygdala Serotonin Clearance and RecentFear Memory Recall

Abstract Converging evidence implicates dysregulation of serotonin in emotion-related psychiatric disorders. Leading pharmacotherapies for such disorders, including general anxiety and posttraumatic stress disorders, target the serotonin transporter (SERT); yet, selective seroton...

Community-Identified Barriers and Strategies for Improving HPV Vaccination in South Texas

Bexar County is a South Texas county with low human papillomavirus (HPV) vaccination rates, which hinders efforts to prevent HPV-related cancers. We conducted a community assessment from the perspective of community members who administer social/health services and/or coalitions...

Engineering SIM-1 and MZ-1 PROTACs for enhanced target degradation in KSHV-infected immortalized endothelial cells

Kaposi’s Sarcoma-associated Herpesvirus (KSHV) is the etiologic agent of several human cancers, including Kaposi’s Sarcoma (KS), which are still lacking of treatment options. Members of the bromodomain and extra-terminal domain (BET) family, especially bromodomain-containing prot...

Consensus based expert recommendations for management and prevention of RSV infections in older adults in emerging market countries: results from an expert panel structured survey

BACKGROUND: Respiratory syncytial virus (RSV) can cause serious disease in older adults (OAs), particularly those with comorbidities. It is a leading cause of acute respiratory illness and lower respiratory tract infections in adults ≥60 years. Its impact on morbidity, mortality,...

Multidisciplinary management of adult-type ovarian granulosa cell tumor in a patient with severe peripheral arterial disease and chronic limb-threatening ischemia: a case report

Reports describing the concurrent management of adult-type granulosa cell tumor (AGCT) and chronic limb-threatening ischemia (CLTI) are exceedingly rare, highlighting the challenges of treating a rare gynecologic malignancy in a medically fragile patient with severe peripheral ar...

Buddy Wire–Augmented Intravascular Lithotripsy in Refractory Calcified Coronary Lesions: A Five‐Case Series

Heavily calcified coronary lesions remain a major challenge in percutaneous coronary intervention (PCI), often limiting the effectiveness of intravascular lithotripsy (IVL). We report a five-case series in which IVL failed to achieve adequate lesion modification but was successfu...

MutFormer: a multimodal deep learning framework for predicting somatic mutation hotspots from sequence and chromatin features

Somatic mutations are unevenly distributed across the genome, with certain loci recurrently mutated across independent tumors. Both local DNA sequence context and chromatin organization have been associated with mutation rate variation, yet their combined effects at single-nucleo...

Association of Accelerated Biological Age in Midlife with Cardiovascular Events, Dementia, and All-Cause Mortality in the Framingham Offspring Study

Accelerated biological age (ABA) better capture the aging process than chronological age (CA) and has been linked to adverse health outcomes, but long-term associations remain unclear. We modeled ABA using anthropometric and biochemical biomarkers across three examination cycles...

Targeting a CDH1–TK1–dependent DNA Synthesis Pathway Overcomes Chemoresistance in Acute Myeloid Leukemia

ABSTRACT Relapsed and refractory acute myeloid leukemia (AML) remains difficult to treat, in part because leukemic cells adapt to nucleoside analogue‐induced replication stress. Here, we identify thymidine kinase 1 (TK1) as a functional contributor to chemotherapy resistance in A...

The impact of structural variation on Alzheimer’s disease in the Alzheimer’s disease sequencing project

Structural variants (SV), genomic alterations spanning more than 50 base pairs, can significantly impact gene expression and protein function. However, their contribution to Alzheimer’s disease (AD) remains poorly understood. Leveraging a novel SV calling pipeline, we identified...

Towards Automating Junctional Hemorrhage Control Using AI for Interpretation of Human Tissue

Junctional hemorrhage has a high fatality rate due to how difficult it is to control rapid bleeding from major vessels. The available methods to stop junctional blood loss are prone to placement errors as well as failure during transport and during prolonged field care. On the ba...

Non-enzymatic hepatic ABHD6 interacts with Akt-FoxO1 axis to regulate metabolic health

The enzymatic role of ABHD6 in insulin secretion and resistance is well documented. However, its non-enzymatic function, especially its effects on metabolic health, including selective hepatic insulin resistance and metabolic dysfunction-associated steatotic liver disease (MASLD)...

Effects of ursodeoxycholic acid on blood glucose and related metabolic indexes in type 2 diabetes rats

Bile acids (BAs) play critical roles in regulating glucose, lipid and energy metabolism, but its effects on type 2 diabetes is not very clear, we studied the effects of ursodeoxycholic acid (UDCA) intervention on blood glucose and related metabolic indexes in type 2 diabetes rats...