The University of Texas at San Antonio Health Science Center

Mild behavioral impairment and risk of incident dementia: A systematic review and meta-analysis

BackgroundLate-life emergence of persistent behavioral changes has been recognized as a clinically meaningful sign of neurodegeneration. These neuropsychiatric symptoms, operationalized as mild behavioral impairment (MBI), represent a unique pathway through which early dementia s...

Aerobic Exercise Ameliorates Renal Injury in High‐Fat Diet‐Fed Mice: A Novel Effect Mediated by the Drp1‐mtROS Pathway

AIM: Aberrant activation of dynamin-related protein 1 (Drp1) promotes excessive mitochondrial reactive oxygen species (mtROS) production; however, whether the Drp1-mtROS pathway mediates the renoprotective effects of aerobic exercise remains unclear. METHODS: High-fat diet (HFD)-...

Factors Associated With Receipt of Adjuvant Radiation in Locally Advanced Rectal Cancer

ABSTRACT Background Neoadjuvant radiotherapy (RT) has been the standard of care for locally advanced rectal cancer (LARC) for over two decades. Adjuvant RT use in LARC represents a deviation from standard care and warrants further investigation. Objectives To identify factors ass...

The 1H, 15N and 13C backbone resonance assignments of an intrinsically disordered region (467–696) of breast cancer type 1 susceptibility protein (BRCA1)

The tumor suppressor protein breast cancer type 1 susceptibility protein (BRCA1) plays a central role in maintaining genome stability through its involvement in DNA damage repair, transcriptional regulation, and cell-cycle control. BRCA1 functions as an obligate heterodimer with...

Superlarge-Bore Versus Large-Bore Aspiration Catheters in Mechanical Thrombectomy: A Multicenter Propensity-Matched Analysis

BACKGROUND AND OBJECTIVES: Aspiration catheters are an integral component of mechanical thrombectomy for acute ischemic stroke (AIS). Following early series demonstrating increasing procedural efficiency and improved outcomes with use of large-bore (LB) aspiration catheters, ther...

Human Muscle-Derived Cells Injected into Acute and Chronic Muscle Injuries Engraft and Support Regenerative Markers

Urinary incontinence (UI), the involuntary leakage of urine, is a common condition that imposes significant physical, emotional, and financial burdens. Injury to the external urethral sphincter (EUS) contributes to myogenic UI by damaging the skeletal muscle responsible for urina...

Elacestrant in Combination with Everolimus for Estrogen Receptor-Positive, HER2-Negative Previously Treated Advanced Breast Cancer: Results from ELEVATE

PURPOSE: Treatment options for progression on first-line endocrine therapy (ET)+CDK4/6i for ER-positive/HER2-negative (ER+/HER2-) advanced breast cancer (ABC) include ET plus targeted agents (CDK4/6i or PI3K/AKT/mTOR-pathway inhibitors). Elacestrant is the first single-agent oral...

Uveitis-Associated Ocular Hypotony: A Systematic Review

INTRODUCTION: Chronic hypotony is an uncommon but potentially vision-threatening complication of uveitis, particularly in pediatric populations. This review synthesizes current evidence on its pathophysiology, epidemiology, clinical presentation, diagnosis, management, and progno...

Alcohol reshapes liver zonal plasticity and immune-metabolic reprogramming in metabolic-syndrome associated hepatocellular carcinoma

Hepatocellular carcinoma (HCC) commonly arises in metabolic dysfunction-associated steatohepatitis (MASH), alcohol-related liver disease (ALD), and metabolic dysfunction-associated ALD (MetALD), yet how zonal metabolic programs govern tumor lineage and immune responses remains un...

Fire-Smoke InducedProtein Alterations in Firefighters'Body Fluids Identify Prognostic Pan-cancer Biomarkers

Abstract Firefighters are routinely exposed to complex mixtures of toxicants during fire suppression, and growing evidence links these exposures to elevated cancer risk. Proteomic profiling provides a sensitive means to detect early molecular alterations associated with such occu...

National Trends, Postoperative Antibiotic Utilization, and Complications Following Operative Management of Mandibular Condylar Fractures: A TriNetX Database Review

BACKGROUND: Debate persists regarding the management of condylar fractures. While systematic reviews and retrospective studies have examined clinical outcomes, national complication profiles, and postoperative antibiotic utilization remain incompletely characterized. METHODS: The...

Serotonin Transporterand Organic Cation Transporter3 Contribute to Basolateral Amygdala Serotonin Clearance and RecentFear Memory Recall

Abstract Converging evidence implicates dysregulation of serotonin in emotion-related psychiatric disorders. Leading pharmacotherapies for such disorders, including general anxiety and posttraumatic stress disorders, target the serotonin transporter (SERT); yet, selective seroton...

Community-Identified Barriers and Strategies for Improving HPV Vaccination in South Texas

Bexar County is a South Texas county with low human papillomavirus (HPV) vaccination rates, which hinders efforts to prevent HPV-related cancers. We conducted a community assessment from the perspective of community members who administer social/health services and/or coalitions...

Consensus based expert recommendations for management and prevention of RSV infections in older adults in emerging market countries: results from an expert panel structured survey

BACKGROUND: Respiratory syncytial virus (RSV) can cause serious disease in older adults (OAs), particularly those with comorbidities. It is a leading cause of acute respiratory illness and lower respiratory tract infections in adults ≥60 years. Its impact on morbidity, mortality,...

Engineering SIM-1 and MZ-1 PROTACs for enhanced target degradation in KSHV-infected immortalized endothelial cells

Kaposi’s Sarcoma-associated Herpesvirus (KSHV) is the etiologic agent of several human cancers, including Kaposi’s Sarcoma (KS), which are still lacking of treatment options. Members of the bromodomain and extra-terminal domain (BET) family, especially bromodomain-containing prot...

Multidisciplinary management of adult-type ovarian granulosa cell tumor in a patient with severe peripheral arterial disease and chronic limb-threatening ischemia: a case report

Reports describing the concurrent management of adult-type granulosa cell tumor (AGCT) and chronic limb-threatening ischemia (CLTI) are exceedingly rare, highlighting the challenges of treating a rare gynecologic malignancy in a medically fragile patient with severe peripheral ar...

Buddy Wire–Augmented Intravascular Lithotripsy in Refractory Calcified Coronary Lesions: A Five‐Case Series

Heavily calcified coronary lesions remain a major challenge in percutaneous coronary intervention (PCI), often limiting the effectiveness of intravascular lithotripsy (IVL). We report a five-case series in which IVL failed to achieve adequate lesion modification but was successfu...

MutFormer: a multimodal deep learning framework for predicting somatic mutation hotspots from sequence and chromatin features

Somatic mutations are unevenly distributed across the genome, with certain loci recurrently mutated across independent tumors. Both local DNA sequence context and chromatin organization have been associated with mutation rate variation, yet their combined effects at single-nucleo...

Association of Accelerated Biological Age in Midlife with Cardiovascular Events, Dementia, and All-Cause Mortality in the Framingham Offspring Study

Accelerated biological age (ABA) better capture the aging process than chronological age (CA) and has been linked to adverse health outcomes, but long-term associations remain unclear. We modeled ABA using anthropometric and biochemical biomarkers across three examination cycles...

Targeting a CDH1–TK1–dependent DNA Synthesis Pathway Overcomes Chemoresistance in Acute Myeloid Leukemia

ABSTRACT Relapsed and refractory acute myeloid leukemia (AML) remains difficult to treat, in part because leukemic cells adapt to nucleoside analogue‐induced replication stress. Here, we identify thymidine kinase 1 (TK1) as a functional contributor to chemotherapy resistance in A...