The University of Melbourne

Coronary Plaque Burden and Plaque Composition in Long-Term Cancer Survivors: A Comparative CCTA Study

Abstract Background The increased risk of atherosclerotic cardiovascular disease in cancer survivors is not fully elucidated. Understanding the coronary plaque burden and composition in survivors could address this gap. Objectives To determine whether cancer survivorship is assoc...

Prevalence of and risk factors for leptospirosis exposure in cattle in Ho Chi Minh City, Viet Nam, 2022

A cross-sectional study was conducted in 2022 to estimate the true prevalence of Leptospira spp. exposed cattle herds in Ho Chi Minh City, Viet Nam and to identify characteristics associated with herd level Leptospira spp. exposure. Herd managers completed a questionnaire about h...

Using well‐being literacy to align capability‐based learning with well‐being curriculums in Australian secondary schools

Abstract This reflective piece draws a link between recent work in Well‐being Science and capability‐based learning to increase the transferability of well‐being curriculums. We propose that a capability‐based approach to well‐being curriculum may assist students to activate the...

Prevalence and inter-relationship of depressive symptoms, anxiety symptoms and poor sleep quality and their associations with quality of life in patients with coronary heart disease: findings from a large nationwide survey

Patients with coronary heart disease (CHD) commonly experience depressive and anxiety symptoms, poor sleep quality, and low health-related quality of life (HRQoL). However, inter-relationships between such mental health problems at a symptom level and their associations with HRQo...

Housing discrimination as a field in the making: institutional coupling, epistemic accumulation, and the uneven production of knowledge (1972–2022)

Abstract Housing discrimination remains a persistent source of inequality in access to housing and related life chances. Yet the evolution of academic knowledge on this phenomenon has rarely been examined as an object of inquiry in its own right. This article asks how research on...

Linking Hydrological Pathways and Organic Matter Dynamics to Water Colour in Temperate Forested Catchments

Abstract Water colour, derived from chromophoric dissolved organic matter (cDOM), is a key indicator of water quality. Increasing water colour trends worldwide and in Australia have raised concerns, yet the drivers of colour variability in natural ecosystems remain poorly underst...

The Impact of Intrathecal Hydrophilic Opioids on Postoperative Pain, Opioid Consumption and Adverse Events for Abdominal Surgery: A Systematic Review and Meta-analysis

Abstract Purpose of Review Intrathecal morphine (ITM) is a promising analgesic option for major abdominal surgery, but its clinical efficacy, potential adverse events and optimal dosing require further investigation. Methods We searched MEDLINE, Embase, and Cochrane Central Regis...

Proliferative Sparganosis Due to Spirometra mansoni in a Dog: A Detailed Diagnostic Picture

ABSTRACT A young Blue Heeler presented for abdominal distension and weight gain, without a history of raw feeding or travel outside the western suburbs of Melbourne, Victoria, Australia. Abdominal ultrasound noted innumerable small anechoic oval cystic structures scattered throug...

Progress and challenges in expanding access to clinical trials in pancreatic cancer

Clinical trials are essential for developing new cancer treatments and improving patient care. However, participation remains low across oncology and is particularly challenging for people with pancreatic cancer, who often experience rapid disease progression, limited treatment o...

From frameworks to futures: health adaptation pathways across the Shared Socioeconomic Pathways

Abstract Effectively managing the rising health risks of climate change requires consideration of plausible adaptation pathways under a range of scenarios of changes in greenhouse gas emissions and socioeconomic development to systematically explore the solution space for climate...

Dentists’ experiences treating children and adolescents with intellectual and developmental disabilities in India: A descriptive qualitative study

The study explored dentists' perspectives and experiences providing dental care for children and adolescents with intellectual and developmental disabilities in India. A descriptive qualitative research approach was employed, utilising semi-structured interviews with dentists pra...

Pharmacological Inhibition of Small Extracellular Vesicle Secretion by ALK5i SD‐208 via Lysosomal Rerouting of CD63+ Compartments

ABSTRACT Pharmacological tools to selectively modulate extracellular vesicle (EV) secretion are scarce. Here, we identify the ALK5 (TGF‐β receptor I) inhibitor SD‐208 as a potent suppressor of small EV (sEV) secretion that acts independently of its canonical anti‐fibrotic activit...

Selective Packaging of miR‐22 and miR‐29 Orthologues into Extracellular Vesicles of the Porcine Whipworm Trichuris Suis

ABSTRACT Helminths modulate host immunity, and in this respect, the porcine whipworm Trichuris suis has been explored clinically as an immunotherapy for inflammatory diseases. T. suis secretes a complex mixture of excretory/secretory products (ESP), including extracellular vesicl...

Céline Sciamma’s writing through desire: A new approach to writing women’s stories

The hero’s journey and the conflict model of storytelling have had a strong hold on western screenwriting since the mid-twentieth century. Increasingly, this is being questioned, especially by feminist scholars and storytellers, who find the hero’s journey exclusive of women’s st...

Shared Leadership in Schools: A Systematic Literature Review and Future Research Agenda

Effective leadership is increasingly recognized as emerging from mutual understanding and shared responsibility. Shared leadership places greater emphasis on the sharing of leadership roles and influence. However, current understandings of shared leadership in the school context...

Thermo-mechanical behavior of stainless-clad bimetallic steel-concrete thermal energy storage unit during initial charging

Concrete cracking induced by significant thermal expansion mismatch between encased stainless steel pipes and surrounding concrete remains a critical barrier limiting the application of concrete-based Thermal Energy Storage (TES) systems in high-temperature scenarios. To address...

Parent and child preferences for a community-based physical activity participation intervention for children born very preterm: a qualitative framework analysis

PURPOSE: Children born very preterm (VP: <32 weeks' gestation) are less physically active than their term-born peers and face greater barriers to participation in community-based activities. This study consults with key knowledge holders (children born VP and their parents) to un...

'A sideshow to the great tragedies in Europe’: colonialism and Holocaust in Abdulrazak Gurnah’s Afterlives

Abdulrazak Gurnah’s 2023 novel Afterlives traces a direct line between the history of German colonialism in East Africa and the Holocaust. The act of drawing such connections has been subject to fierce debate in Germany in the Historikerstreit 2.0. Gurnah’s work calls attention t...

A necroptotic-to-apoptotic signaling axis underlies inflammatory bowel disease

ABSTRACT Inflammatory bowel disease (IBD) is a chronic condition caused by altered cytokine signaling, maladaptive immunity, dysbiosis, and intestinal barrier dysfunction. Patients with IBD receive therapy to correct these imbalances and achieve remission. However, most patients...

Leisure-time physical activity for middle-aged and older people with spinal cord injuries: beyond physical gains and individual responsibility

Abstract Study design We conducted a descriptive qualitative study. Objective To identify strategies to enhance access to and engagement in leisure-time physical activity (LTPA) for Australians aged ≥45 years of age with spinal cord injury, with the view to address the high rate...