The University of Melbourne

Balancing training load, rest and musculoskeletal injury risk: a mathematical modelling study in Thoroughbred racehorses

Abstract Musculoskeletal injuries (MSI) in Thoroughbred racehorses are a leading cause of death and premature retirement, and are heavily influenced by training practices. Greater distances of high-speed galloping accumulated during racing campaigns are associated with MSI. Bone...

Technical Review: Performance, Design, and Deployment of Steel Helical Pile Groups for Transmission Infrastructure

Worldwide transmission-grid expansion requires extensive construction of new tower foundations across diverse geological, environmental, and logistical conditions, while conventional bored piling faces increasing cost, schedule, constructability, and adaptability constraints. Ste...

Evaluating Interventions for Plasmodium vivax Forest Malaria Using a Three-Scale Mathematical Model

Abstract. The rising proportion of Plasmodium vivax cases concentrated in forest-fringe areas across the Greater Mekong Subregion (GMS) highlights the importance of pharmaceutical and mosquito control techniques specifically targeted toward forest-going populations. To mathematic...

Astrocytic activity in treatment-resistant and ultra-treatment-resistant schizophrenia

Astrocytic dysfunction has been implicated in schizophrenia, but biomarkers of astrocytic activity have shown inconsistent patterns. Studies on disease heterogeneity, specifically treatment-resistant schizophrenia (TRS) and ultra-treatment-resistant schizophrenia (UTRS) are lacki...

Geoeconomic embeddedness and transnational migrant entrepreneurship: Chinese–Australian wine exporters in a decade of volatility

This article critically examines the entrepreneurial trajectories of Chinese–Australian wine exporters between 2015 and 2025, a decade marked by volatility in Australia–China relations. Drawing on four in-depth qualitative case studies, it explores how transnational migrant entre...

Physical Activity and Risk of Liver Cancer: A Competing Risk Analysis

Physical activity is associated with lower risk of liver cancer, but obtaining an unbiased estimate of the causal effect is challenging due to the competing risk of death due to any other cause. We performed a causal competing risk analysis to estimate the total effect of physica...

Reversible Inhibition of Ammonia Monooxygenase by 1,9-Decanediol Triggers a RegB-RegA-Associated Energy Crisis and Stress Response in Nitrosomonas europaea

Abstract 1,9-decanediol, a rice-derived biological nitrification inhibitor (BNI) suppresses soil nitrification and nitrous-oxide emissions, but the mechanisms of action against ammonia-oxidizing bacteria remain unclear. Combining physiology and transcriptomics in Nitrosomonas eur...

MAIA frailty subgroup analysis: long-term follow-up with daratumumab plus lenalidomide/dexamethasone in transplant-ineligible newly diagnosed myeloma

Abstract In MAIA (Daratumumab, lenalidomide, and dexamethasone versus lenalidomide and dexamethasone alone in newly diagnosed multiple myeloma), daratumumab plus lenalidomide/dexamethasone (D-Rd) improved progression-free survival (PFS) and overall survival (OS) versus Rd in tran...

Deformation-enhanced fluid evolution and skarn–IOCG transition in the Paleoproterozoic Elaine Dorothy Cu–Au system, Mount Isa Inlier, Australia

Abstract The Elaine Dorothy Cu-Au deposit, located in the Mary Kathleen Domain of the Mount Isa Inlier, Australia, records the interaction of Paleoproterozoic skarn metasomatism, fluid evolution, and deformation. The deposit is hosted by carbonate- and calc-silicate-rich rocks of...

The Framework for Policy Decision on the RTS,S/AS01 malaria vaccine: the use of emerging data to inform global policy on the first malaria vaccine

The World Health Organization (WHO)-coordinated Malaria Vaccine Implementation Programme (MVIP) supported pilot introductions of the RTS,S/AS01 malaria vaccine by the ministries of health through the childhood immunization programmes in Ghana, Kenya and Malawi from 2019 through 2...

Establishing Stakeholder Priorities for Development of a Multi‐Arm Multi‐Stage Platform Trial in Crohn's Disease

ABSTRACT Background and Aims The expanding range of advanced therapies for Crohn's disease (CD) has increased complexity in treatment selection, particularly in refractory disease. Conventional randomised controlled trials are limited in evaluating multiple treatment strategies e...

Investigating the thermal degradation of multi-board decking materials ignited by firebrand piles

Background Firebrand piles are a major contributor to structural losses during wildland–urban interface fires. Among potential recipient fuels, decking materials exhibit ignition susceptibility that is strongly dependent on material type. However, experiments on representative mu...

Perspectives on primary care management of chronic hepatitis B in refugees: findings from qualitative interviews with healthcare providers in Melbourne, Victoria

Background In Australia, healthcare providers face significant challenges in meeting the niche health needs of refugees. Social determinants of health, including limited health literacy and finances, complicate refugees’ access to treatment for conditions, such as chronic hepatit...

Cost‐Consequence Analysis of a Dementia Specialist Training Program for Home Care Workers: Results From a Stepped‐Wedge Cluster‐Randomised Controlled Trial

OBJECTIVES: This paper reports the health economic component of the broader Promoting Independence Through Quality Dementia Care at Home (PITCH). The broader PITCH trial primarily evaluated the effect of dementia training on home care workers' competence in providing dementia car...

The Role of A Surgeon in Restoring the Senses & in Biomedical Engineering

ABSTRACT This review is based on my 2025 Jepson Lecture and outlines my personal journey to restore hearing in people with a severe sensorineural hearing loss. My dream started as a 5‐year‐old as I told my kindergarten teacher when I grow up ‘I want to fix ears’ because my father...

Posigence, Negligence’s Positive Counterpart: An Empirical Investigation

Is there a positive counterpart to negligence? In the philosophical literature, there is a widespread asymmetry assumption according to which agents can be blameworthy for unwitting wrongdoing (negligence) but not praiseworthy for unwitting rightdoing. This project empirically ex...

Strategies adopted by construction firms to overcome the challenges of adopting Industry 4.0: an Australian perspective

Purpose Industry 4.0 (I4.0) presents a significant potential for digital transformation in the construction industry (CI), yet a substantial implementation gap remains. Despite digital advancements in Australian CI, many firms struggle to translate digital potential into operatio...

After the fires: plant responses and resilience under shifting fire regimes

The changing climate is reshaping our fire regimes, with fires of record-breaking extent, severity and frequency occurring around the world. The 2019–2020 Black Summer bushfires in Australia were a landmark event that revealed both the depth and the limits in our understanding of...

Sprache in Bewegung: von KI bis Rollenspiel. Perspektiven, Herausforderungen und Innovationen in German Studies Australien

Der Beitrag reflektiert vier Unterrichtsbeispiele aus dem German Program der University of Melbourne und verortet sie im Spannungsfeld zwischen Deutsch als Fremdsprache, German Studies und Auslandsgermanistik. Vor dem Hintergrund sinkender Studierendenzahlen, heterogener Lerngrup...

Management of De Novo miN1 Prostate Cancer in the PSMA-PET Era.

BACKGROUND: Prostate-specific membrane antigen positron emission tomography (PSMA-PET) is reshaping nodal staging in prostate cancer by detecting regional lymph node metastases with greater accuracy than conventional imaging. This has created a new cohort of patients with N1M0 di...