Institution
The University of Melbourne
Recent research
- Health & MedicineOpen access
Background: Reproducibility and comparability of disability outcomes remain major challenges in multiple sclerosis (MS) research. Definitions of disability progression vary widely across studies, and calculation criteria are often insufficiently documented to enable replication....
- BiologyOpen access
Abstract Objective The polygenic risk score (PRS) for individuals with genetic generalized epilepsy (GGE) quantifies the common risk variants in genes identified in genome‐wide association studies. We hypothesized that the phenotype of GGE patients differs based on their GGE PRS....
- Health & MedicineOpen access
Abstract Topic Benign Disease: Gastro-Esophageal Reflux and Hiatal Hernia Background Hiatus hernias are relatively common and can be associated with adverse symptoms and serious complications. Operative repair is indicated in this patient group for symptom management and the prev...
- Health & MedicineOpen access
Abstract Background Previous research suggests higher risk of prostate cancer diagnosis in men with high vitamin D serology, but there are limited data related to prostate cancer survival. In this study, we examine the associations between prediagnostic circulating levels of 25-h...
- BiologyOpen access
Infradian rhythms of human heart rate reveal distinct multiday cycle periods in healthy adults
BACKGROUND: Chronobiology research has historically focused on circadian rhythms; however, longer infradian rhythms are prevalent in human physiology and may have important implications for health and wellbeing. Previous studies have identified widespread infradian rhythms across...
- BiologyOpen access
The DLX/Notch axis is necessary for spatiotemporal regulation of neural cell fate
Neuronal-glial cell fate switch during forebrain development is highly regulated. DLX transcription factors are necessary for promoting GABAergic interneuron differentiation and migration but the mechanisms for concomitant repression of glial fate in neural progenitors remain elu...
- AI & ComputingOpen access
Multi-pathogen situational assessment and forecasting of respiratory disease in Aotearoa New Zealand
Abstract Real-time analysis of epidemic trends and forecasts can help support public health planning and the response to seasonal respiratory disease. Here, we present two models that were used in a 2025 New Zealand winter situational assessment programme for three respiratory pa...
- Health & MedicineOpen access
Novel chimeric PD-L1::PD-L2 fusion and immune evasion in lymphoma
We report a novel in-frame CD274::PDCD1LG2 fusion in primary mediastinal B-cell lymphoma. Functional studies using expression constructs and CRISPR-engineered lymphoma cells confirmed formation of a PD-L1::PD-L2 chimeric protein and marked upregulation of PD-L1 surface expression...
- Engineering & TechnologyOpen access
Graphene‐Engineered Rear Interfaces Enable Efficient Flexible CZTSSe Solar Cells on Metal Foils
ABSTRACT Flexible kesterite (S,Se) (CZTSSe) solar cells on metal foils are attractive for lightweight and conformable photovoltaic applications, yet their efficiencies remain significantly lower than those of rigid devices due to severe foil‐induced rear‐interface losses during h...
- Health & MedicineOpen access
Abstract Background Accurate prognostication of mobility outcomes is essential to guide rehabilitation and manage patient expectations. The prognostic utility of neuroimaging and neurophysiological biomarkers remains uncertain when measured early post-stroke. This systematic revi...
- Society & Economics
Values play a central role in living a fulfilling life. However, the literature on interventions to clarify core values is widely dispersed. To address this, we performed a systematic review of RCTs that encouraged participants to select, reflect on, and (occasionally) act on the...
- Health & MedicineOpen access
Background Syphilis is increasing worldwide, and secondary syphilis may represent its most infectious stage. Scarce data exist on Treponema pallidum clearance after treatment. We aimed to determine the frequency and load of T. pallidum mucosal shedding, and time to clearance foll...
- Health & MedicineOpen access
A multi-centre study of belatacept and sirolimus for islet transplantation
Abstract Aims/hypothesis Islet transplantation is an appropriate treatment for selected individuals with type 1 diabetes mellitus and hypoglycaemia unawareness. The gold standard of maintenance immunosuppression to prevent allograft rejection is calcineurin inhibitor-based therap...
- Health & MedicineOpen access
Monthly or menstrual? A scoping review of catamenial epilepsy and non‐menstrual seizure rhythms
OBJECTIVE: Despite the reported high prevalence of catamenial epilepsy (CE), the condition remains poorly defined, with lack of consensus on what entails a menstrual-related seizure exacerbation. Emerging evidence of multiday cycles of seizure activity, including about-monthly cy...
- Health & Medicine
High risks of unintended pregnancies and abortion have been reported among Chinese university students; however, their contraceptive use remains poorly understood. This study synthesised Chinese university students' contraceptive usage to inform the development of context-specifi...
- Biology
Introduction: Genomic testing has substantial diagnostic and clinical value in nephrology, yet integrating testing into routine care requires service-level changes to ensure timely and equitable access. Methods: We conducted an observational cohort study at four tertiary centres,...
- AI & ComputingOpen access
When indemnity insurance fails: Parametric coverage under binding budget and risk constraints
Abstract In high‐risk environments, traditional indemnity insurance is often unaffordable or ineffective, despite its well‐known optimality under expected utility. We compare excess‐of‐loss indemnity insurance with parametric insurance within a common mean‐variance framework, all...
- Health & MedicineOpen access
Metabolic dysfunction–associated steatohepatitis (MASH) is a rapidly escalating global health challenge driven by complex interactions among metabolic regulation, nutrition, immune signalling, gut microbiota, and environmental exposures. Current disease-centric frameworks priorit...
- BiologyOpen access
Unveiling centromeric retrotransposon dynamics through a high-quality rye genome assembly
Abstract Rye ( Secale cereale L.) is an important cereal crop known for its high yield potential and tolerance to biotic and abiotic stresses. However, its large, repeat-rich, and heterozygous genome has posed challenges for assembly compared to related species such as wheat and...
- Health & MedicineOpen access
ABSTRACT Introduction Up to one in two individuals who have a history of an ankle injury will develop chronic ankle instability, which subsequently increases the risk of osteoarthritis development. Although lateral ankle ligament injuries are the most common, recent research show...