The University of Melbourne

Analysis of the Topology of a Plasmonic Target-Skyrmion Texture

Abstract Topological concepts are frequently used to describe structured optical fields, including plasmonic near fields. Topological descriptions in terms of skyrmion numbers implicitly assume the compactness of the underlying manifold. While this concept works for constrained f...

Bioinformatics-Driven Identification of Flooding-Tolerance Genes and Their Structural and Molecular Characterization in Soybean

Abstract Flooding stress is one of the important abiotic factors restricting soybean production globally. Despite numerous efforts, the genetic mechanisms of flooding tolerance are not fully understood. This work used a bioinformatics-driven, integrative approach combining struct...

Paediatric haematopoietic stem cell transplantation research priorities: Results from an international multi‐stakeholder priority setting partnership

Summary Co‐designed research in paediatric HSCT is limited. We sought to determine research priorities which represent the shared priorities of patients, parents, carers and healthcare professionals (HCP) within Australia, New Zealand, the Netherlands and the United Kingdom. An i...

Cloud‐Native and Distributed Systems for Efficient and Scalable Large Language Models—A Research Agenda

ABSTRACT Objective Large Language Models (LLMs) are rapidly transforming artificial intelligence applications, but their unprecedented computational, memory, communication, and data‐management demands pose significant challenges to existing computing infrastructures. Traditional...

Multidomain Post-Concussive Symptom Trajectories and Biopsychosocial Correlates Following Pediatric Concussion

IMPORTANCE: Understanding how post-concussive symptoms (PCS) evolve across multiple domains and how these patterns relate to biopsychosocial factors is critical for identifying children at risk of prolonged recovery following concussion. OBJECTIVE: To identify clinically meaningf...

Anogenital distance in adult women: examining a new biomarker in gynaecology

Anogenital distance (AGD) is proposed as a marker of the prenatal hormonal environment and reportedly differs in women with endometriosis, polycystic ovary syndrome and impaired fertility. Before clinical use, its normal range, determinants and measurement reproducibility must be...

Effects of testosterone on exercise capacity in postmenopausal women with stage B heart failure

Objective Asymptomatic individuals with stage B heart failure (HF) often have reduced exercise capacity. As exogenous testosterone may have favorable skeletal muscle and vasculature effects, this study investigated whether transdermal testosterone improves exercise capacity in wo...

Prospective phase I study of nivolumab to promote graft‐versus‐tumour in relapsed or refractory haematological malignancy post allogeneic haematopoietic stem cell transplantation

Summary Allogeneic haematopoietic stem cell transplantation (alloHSCT) relies on donor‐derived T cells to mediate the graft‐versus‐tumour (GVT) effect, but relapse may result from impaired immune reconstitution, tumour antigen downregulation or T‐cell exhaustion. This prospective...

Differences in contraceptive practice between Chinese and non-Chinese international students in an Australian university

BACKGROUND: Use of contraceptive among international university students remains under-explored. This study examined contraceptive use at last sex among international students in Australia, comparing Chinese (the largest source-country group) with non-Chinese students. METHODS: P...

In Vivo Blood Kinetics and Transcript Integrity of Three mRNA–Lipid Nanoparticle Vaccines in Humans

Abstract mRNA–lipid nanoparticle (LNP) vaccines are detectable in human blood after vaccination, but platform-specific differences in systemic persistence and transcript integrity remain poorly defined. We analyzed serial blood samples from 73 participants receiving Moderna mRNA-...

Innovation adoption across regions: psychological openness and the early diffusion of digital platforms

Early regional adoption is crucial for platform-enabled innovations because their viability depends on enough people within a region adopting them to generate network effects. Existing research on regional innovation diffusion explains early adoption largely through demographic,...

Understanding rotavirus vaccine acceptance in Indonesia: a WHO BeSD-based exploration of parents' and religious leaders' perspectives in three provinces

Background Disparities in rotavirus vaccine uptake in Indonesia persist despite its national implementation, yet, the community-level determinants of vaccination remain underexplored. Understanding the behavioural and social factors influencing vaccination decisions is essential...

What are people saying about DoxyPEP? A topic-based analysis of Reddit discussions

BACKGROUND: Doxycycline post-exposure prophylaxis (DoxyPEP) is a strategy for bacterial STIs prevention; however, despite strong evidence from clinical trials that DoxyPEP reduces the incidence of syphilis and chlamydia, its real-world uptake is shaped by public perception. In th...

Circulating biomarkers in the diagnosis and management of neuroendocrine neoplasms

Abstract Neuroendocrine neoplasms (NENs) comprise a broad family of tumours arising from the diffuse neuroendocrine system and endocrine glands, and vary widely in clinical behaviour ranging from indolent to highly aggressive. Established monoanalyte biomarkers including chromogr...

An Exploratory Study of ABT-806, a Tumor-Specific Anti-EGFR Antibody, in Subjects with Recurrent or Metastatic Head and Neck and Other Squamous Cell Carcinomas

Introduction: Despite their benefit, current anti-EGFR therapies are limited by narrow efficacy profiles due to dose-limiting toxicities. This phase 2 open-label study evaluated the efficacy and safety of ABT-806, an EGFR-targeting antibody that is tumor specific, in patients wit...

Multi-level governance constraints on the local science–policy–practice interface: Evidence from Ho Chi Minh City flood management

Stronger collaboration between science, policy and practice is widely acknowledged as essential for addressing escalating climate risks, yet the governance structures shaping such collaboration are often overlooked. This study brings together Multi-level Governance and Science-Po...

Does pasture diversity enhance growth and nutritive characteristics of dairy pastures in south-eastern Australia?

Context Australia’s dairy production relies predominantly on grazed rainfed perennial ryegrass pastures. Multi-species pastures, including grasses, legumes, and herbs, have potential to improve pasture dry-matter (DM) production and nutritional value, relative to perennial ryegra...

Witchcraft Accusations Against Women: An Intersectional Analysis of the Experience of Spiritual Abuse by Christian Clergy in Ghana

Witchcraft accusations involving Christian ministers in Ghana reveal a pattern of spiritualised violence shaped by intersecting structural inequalities. This article examines how gender, age, poverty, social isolation, and uneven access to state protection converge to make certai...

Stability of the expanding region of Kerr de Sitter spacetimes

We prove the nonlinear stability of the cosmological region of Kerr de Sitter spacetimes. More precisely, we show that solutions to the Einstein vacuum equations with positive cosmological constant arising from data on a cylinder that is uniformly close to the Kerr de Sitter geom...

Leveraging Cubenes to Access Highly Functionalized Fused Cubes

Abstract Since 1913, cubane has fascinated chemists owing to its remarkable structure. More recently, however, cubanes have emerged as attractive bioisosteres for aromatic rings. Although substituted derivatives are relatively common, ring-fused cubanes (a.k.a. “fused cubes”) are...