Sun Yat-sen University

Identification and characterization of ethR and ethA genes impacting the sensitivity of Mycobacterium abscessus to ethionamide

ABSTRACT Mycobacterium abscessus is a rapidly growing non-tuberculous mycobacterium with rising global incidence. This pathogen exhibits intrinsic resistance to most antibiotics, presenting a major public health threat. Ethionamide (ETH) requires bioactivation by monooxygenase Et...

Asian Neurogastroenterology and Motility Association and Asia-Pacific Association of Gastroenterology Chronic Constipation Consensus 2026.

Background/Aims: : Chronic constipation is a common gastrointestinal (GI) disorder in Asia, characterized by heterogeneous symptom presentation, frequent overlap with other GI symptoms, and limited access to specialized diagnostic tests in many settings. These factors contribute...

Cumulative spatial assessment of observed wildlife-vehicle collisions based on indicator species thresholds

Global road network expansion has exacerbated wildlife-vehicle collisions. However, traditional risk assessments predominantly assume a linear relationship between landscape features and observed collision quantities, overlooking the non-linear threshold characteristics of ecolog...

Novel insights of minocycline as a neurovascular protective agent in retinitis pigmentosa

Background/aims Retinitis pigmentosa (RP) is characterised by progressive photoreceptor degeneration accompanied by vascular abnormalities. We have previously demonstrated that minocycline exhibits therapeutic potential in RP. This trial aimed to evaluate its neurovascular protec...

Evaluating global clinical trials and development trends of antibody-drug conjugates

Antibody-drug conjugates (ADCs) represent a breakthrough in tumor-targeted therapy, showing promise in both solid tumors and hematological malignancies. By 1 September 2025, more than 370 ADC candidates had entered clinical development, 17 unique products had received at least on...

Two Modes of Self‐Organizing Development of Extreme Rainfall‐Producing Storms in South China

Abstract The convective‐scale dynamics of extreme rainstorms on monsoon coasts (South China) remain poorly understood. This study uses the advanced coupled model WRF‐Chem‐MOSAIC for a 90‐hr, 3‐km simulation, reasonably capturing the thermodynamic conditions, inhomogeneous near‐su...

Digital Defocus Vision Training Using Virtual Reality for Myopia Control

Importance Virtual reality–based digital defocus vision training (DDVT) may offer a home-based strategy to slow myopia progression in children, but evidence is limited. Objective To evaluate efficacy and safety of a head-mounted virtual reality–based DDVT system on myopia progres...

Ultralow‐Noise Blue‐Green‐Light CsPbBr 3 Photodetectors Enabled by CuSCN Selective Coverage Toward Long‐Distance Underwater Wireless Optical Communication

ABSTRACT The excellent thermal stability and blue‐green spectral response window of all‐inorganic CsPbBr 3 perovskite make it highly suitable for underwater wireless optical communication (UWOC). However, in complex ocean environments, severe optical attenuation limits long‐dista...

Real‐World Glycemic Outcomes of Open‐Source Automated Insulin Delivery During 12 Months Among People With Type 1 Diabetes Across Age Groups

ABSTRACT Aims To assess glycemic outcomes across different age groups and explore factors associated with glycemic target achievement during 12‐months open‐source android artificial pancreas (AAPS) use among people with type 1 diabetes (T1D). Methods This study included people wi...

A phase III clinical trial of PXT3003 in Chinese patients with Charcot-Marie-Tooth disease type 1A

Charcot-Marie-Tooth disease type 1A (CMT1A) is the most common inherited peripheral neuropathy and currently lacks disease-modifying therapy. PXT3003, a low-dose oral combination targeting PMP22 overexpression, has shown efficacy in two trials, while one recent confirmatory trial...

Impact of Donor Age on Short‐Term Outcomes After Pediatric Split Liver Transplantation

BACKGROUND: Split liver transplantation (SLT) expands access to grafts for pediatric recipients, but the short-term implications of donor age at the extremes of the accepted range remain uncertain. METHODS: We retrospectively analyzed 144 pediatric SLT recipients treated from 201...

Multi-Granular Demonstration Retrieval via Syntax-Derived Representations for Few-Shot NL2GQL

Translating natural language into graph query languages (NL2GQL) enables non-expert users to access graph databases, but supervised parsers depend on large annotated corpora and costly retraining whenever the schema evolves. Few-shot in-context learning offers a training-free alt...

Genomic predisposition is associated with the direction of sex chromosome evolution

Sex chromosome evolution is among the most dynamic genomic innovations in vertebrates, yet why some lineages evolve XY while others evolve ZW remains unclear. Using chromosome-level genomes from 19 geckos, we found that gecko sex chromosomes originated independently from 16 ances...

Biogenic Magnetite Indicating Millennial‐Scale Evolution of Bottom Water Oxygenation in the Northern South China Sea Since About 30 ka

Abstract Previous studies indicate that bottom‐water oxygenation (BWO) during glacial–interglacial transitions varies complexly, particularly on millennial timescales. Here we reconstruct millennial‐scale BWO variations since ∼30 ka using biogenic magnetite preserved in sediments...

Heavy Metal Pollution in River Sediments: Risk Assessment, Source Apportionment, and Remediation—A Review Focusing on Chinese River Basins

River sediments act not only as important sinks for heavy metal pollution in watersheds, but also as potential secondary sources under changing environmental conditions. Heavy metals can enter river systems through industrial wastewater discharge, agricultural non-point runoff, u...

Targeting DNA damage signaling in atherosclerosis: molecular mechanisms and therapeutic opportunities

Atherosclerosis is a lipid-driven, chronic inflammatory disease of large and medium-sized arteries that underlies major cardiovascular events and remains a leading cause of mortality and morbidity worldwide. It is characterized by the progressive formation of lipid-rich plaques w...

Single-Cell RNA Sequencing Combined with MEBOCOST Reveals Alveolar Macrophage-Mediated Immunometabolic Communication Mechanisms in Sepsis-Induced Acute Lung Injury

Background: Sepsis-induced acute lung injury (SI-ALI) leads to high mortality in critically ill patients, and no specific targeted treatments are available. Current studies mainly characterize intercellular crosstalk via protein–ligand–receptor frameworks, while metabolite-derive...

Mitochondrial DNA mutation triggers early-onset intestinal epithelial cell dysfunction during acute colitis

Abstract Background Mitochondrial DNA (mtDNA) mutations cause multisystem disorders often involving gastrointestinal dysfunction. However, the mechanisms governing the selection against mutant mtDNA and the specific impact of pathogenic mtDNA mutations on intestinal epithelial ce...

HBV re-activation is associated with increased mortality and dysregulation of oxidative and polyamine metabolism in pre-acute-on-chronic liver failure

Abstract Background/Aims Acute-on-chronic liver failure (ACLF) is one of the deadliest complications of chronic liver disease yet treatment options are sparse. In Asia, HBV-reactivation (HBVr) is one of the most common triggers. Recently, HBV-associated ACLF was associated with d...

Neutrophil Extracellular Trap-Derived DNA Activates the ITGB1/FAK Pathway to Promote Lung Adenocarcinoma Metastasis

Abstract Neutrophil extracellular traps (NETs) have recently emerged as key modulators of cancer progression and metastasis. However, a more comprehensive understanding of the underlying mechanisms could help identify effective strategies to prevent and treat NET-mediated metasta...