Stanford Medicine

Evaluation of a National Mentorship Pilot Program for Early-Career Women in PHM

BACKGROUND: Women comprise most of the pediatric hospital medicine (PHM) workforce yet experience disparities in authorship, leadership, and compensation. Structured mentorship and professional development tailored to early-career women remain limited. Supporting Her in Navigatin...

Gait Speed in Spinal Muscular Atrophy: A Key Vital Sign Linked to Strength and Fatigability

ABSTRACT Introduction/Aims Gait Speed (GS), a valid and reliable indicator of function and health in multiple populations, has not been explored in spinal muscular atrophy (SMA). The purpose of this study was to characterize GS and gait speed reserves (GSR), and explore associati...

Modeling the Exposome in Murine Cardiovascular Disease

Our exposome, encompassing our environmental and lifestyle exposures across the life span, is a critical determinant of cardiovascular health. Clinical and epidemiological data demonstrate that sleep, stress, exercise, smoking, viral respiratory infections, and environmental poll...

A Secret-Shopper Study Evaluating Logistic Barriers to Care Among Young Adults with Acute Lymphoblastic Leukemia

Abstract Adolescents and young adults (AYAs) with acute lymphoblastic leukemia (ALL) experience inferior survival relative to children. As access barriers may increase outcome disparities, we conducted a secret-shopper study to identify logistical burdens when initiating care for...

Oveporexton for Narcolepsy Type 1 — Results from Two Phase 3 Trials

BACKGROUND: Narcolepsy type 1 is characterized by excessive daytime sleepiness, cataplexy, disrupted sleep, sleep paralysis, and hypnagogic or hypnopompic hallucinations. Oveporexton (TAK-861), an oral orexin receptor 2-selective agonist, reduced symptoms of narcolepsy type 1 in...

Efficacy and safety of canagliflozin are consistent across polypharmacy burden in CKD: the CREDENCE trial

Abstract Background Polypharmacy in chronic kidney disease (CKD) is substantial. Clinicians and patients are often reluctant to add medications to already complex regimens, partly due to concerns about diminishing efficacy and increased adverse effects. We assessed whether effica...

It’s a wrap: deriving distinct discoveries with FDR control after a GWAS analysis

Abstract The standard analysis pipeline for genome-wide association studies (GWAS) is based on marginal tests of association. These are computationally convenient and portable, but the discoveries are not immediately interpretable, and require post-processing such as “clumping” a...

Humans: Intertwined with life and the basic elements in the Anthropocene biosphere

Abstract The notion of people and nature as intertwined and embedded in the biosphere is gaining traction in contemporary scientific discourses. But what does it mean for a human being to be intertwined? Here, we explore this question through two lenses: looking at the human body...

Factors Influencing Caregiver Anxiety in the Pediatric Emergency Department

OBJECTIVES: This study identified demographic and experiential factors associated with caregiver anxiety in a pediatric emergency department (PED). METHODS: We conducted a cross-sectional survey of caregivers for children brought to our PED. Participant anxiety was assessed with...

Threatened Identity: Self Psychology Informed Communication for Serious Illness Care

Serious illness threatens both the body and the self: the coherent, continuous sense of who one is, from bodily integrity to psychosocial identity. When illness disrupts identity and patients confront mortality and dependence, a range of responses may follow, including behaviors...

Neurophysiological signatures of Stanford Neuromodulation Therapy in treatment resistant depression

ABSTRACT Objective Stanford Neuromodulation Therapy (SNT) has demonstrated impressive efficacy for treatment-resistant depression (TRD), but its neurophysiological mechanisms remain poorly understood. This study investigated the neurophysiological correlates of SNT using transcra...

International Society of Urological Pathology Multidisciplinary Expert Consultation Conference on Evaluation of Treatment Effects in Prostate and Bladder Cancer

Treatment effects in the urinary bladder are variable and range from localized post-transurethral resection changes to widespread systemic therapy effects. The International Society of Urological Pathology (ISUP) organized a consensus meeting in Vienna, Austria, in September 2025...

Enhanced Osteoinduction, Rheological and Mechanical Performance of 3D-Printed Methylcellulose-Gelatin-Hydroxyapatite Scaffolds

Complex patient-specific bone defects remain difficult to reconstruct because the regenerative capacity of bone is limited and prefabricated implants cannot readily match defect geometry. In this work, methylcellulose-gelatin-hydroxyapatite (MC/GEL/HA) inks were formulated with v...

Utilization of the Functional Lower Extremity Evaluation (FLEE) in Return-to-Sport Rehabilitation Protocol Following Hip Arthroscopy in Collegiate Athletes: A Case Series

Background The Functional Lower Extremity Evaluation (FLEE) is a validated assessment tool designed to assess lower limb function and symmetry. There is a gap in knowledge in return to sport (RTS) regarding the application of the FLEE in RTS rehabilitation protocols following hip...

Addiction recovery is more than abstinence—our metrics should be too

Value-based payment is reshaping U.S. healthcare by linking reimbursement to patient outcomes. Approximately 70% of health plans anticipate growth in value-based payment models over the next two years, with nearly 45% of their healthcare payments in 2024 already using value-based...

Functional Stability Measured by Changes in the 6-min Walk Test in Patients Treated with Tafamidis Versus Placebo: Post hoc Analysis from ATTR-ACT

Tafamidis, a transthyretin stabilizer for the treatment of transthyretin amyloid cardiomyopathy (ATTR-CM), significantly reduced the decline in 6-min walk test (6MWT) distance, a marker of functional stability, compared with placebo in the pivotal study ATTR-ACT. In this post hoc...

TRANCE is a unique marker of chronic pancreatitis in children

BACKGROUND Elucidating immune signals through well-defined cohorts of pediatric acute pancreatitis (AP) and chronic pancreatitis (CP) patients is critical. This study aimed to evaluate plasma chemokine and cytokine levels in pediatric participants with CP, compared with AP and he...

P1.233. Impact of Preoperative Frailty on Long-Term Survival Following Esophagectomy for Esophageal Cancer

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – long term outcomes Background Esophagectomy can provide cure for esophageal cancer yet is associated with high rates of perioperative morbidity. Assessing frailty in the preoperative setting provides supe...

SurfaceProton ReservoirsConstrain Alkalinity Exportfrom Enhanced Weathering

Abstract The addition of silicate and carbonate materials to soils (enhanced weathering) is a proposed carbon dioxide removal (CDR) strategy with potential agronomic co-benefits, especially for soil pH management. However, alkalinity from mineral dissolution interacts with the su...

Ancestry and Kawasaki Disease: Clinical Pathway Considerations

Kawasaki disease (KD) is the leading cause of pediatric acquired heart disease in developed countries.1 Despite decades of research, no established biologic marker has been identified, and KD remains a clinical diagnosis.1,2 However, KD research has shown that different populatio...