Stanford Medicine

Anatomical and Histologic Response to Neoadjuvant Therapy: Recurrence Patterns Among Poor Responders. A Multi-institutional Observational Cohort Study.

OBJECTIVE: To characterize the prognostic implications after hepatectomy for colorectal liver metastases (CRLM) by integrating anatomical response to neoadjuvant therapy (NAT), quantified using the Tumor Burden Score ratio (TBSr), with histologic response assessed by Tumor Regres...

Prevalence of chronic pain among U.S. children with neurodevelopmental disorders.

Introduction: Neurodevelopmental disorders (NDDs) affect up to 15% of children in the United States and are associated with co-occurring health challenges such as chronic pain, which can negatively affect development and quality of life. Increased risk of chronic pain in children...

Stereotactic Radiosurgery for Thalamic Brain Metastases: A Retrospective Analysis and Literature Review.

BACKGROUND AND OBJECTIVES: The thalamus, a neural processor and integrator for forebrain activities, is an uncommon site for metastatic lesions. Stereotactic radiosurgery (SRS) has become a noninvasive treatment for brain metastases. This study assesses the efficacy, safety, and...

SafeSpeaker: Voice Obfuscation for Resource-Constrained IoT Devices

Embodied voice assistants offer an intuitive and powerful interaction modality, but they also pose significant privacy-leakage risks when uploading raw voice recordings to the cloud for processing. These voice recordings contain a wealth of private information beyond just spoken...

A versatile fluorescent reporter for Usutu virus drug screening and infection tracking

Abstract Usutu virus (USUV) is an emerging mosquito-borne orthoflavivirus closely related to West Nile and Japanese encephalitis viruses. Despite its increasing prevalence in Europe and reports of neuroinvasive disease in humans, the molecular and immunological determinants of US...

Clinical Practice Guideline for the Diagnosis and Treatment of Urinary Tract Infection in Children From 8 Days to 5 Years of Age

Urinary tract infection (UTI) is one of the most common bacterial infections in infants and young children, with a prevalence of 7% in infants with fever. This clinical practice guideline (CPG) provides an update of the literature and clinical recommendations of the 2011 American...

Structural basis of stepwise G protein activation by the viral chemokine receptor US28

Abstract G protein-coupled receptors (GPCRs) govern diverse cellular responses and are crucial drug targets. However, the sequence of structural events from G protein recognition to GDP release has remained elusive. Here, we leveraged the viral chemokine GPCR US28 to capture mult...

A Systematic Review and Meta-Analysis of the Prevention and Management of Pediatric Urinary Tract Infection and Suspected Urinary Tract Infection: Technical Report

BACKGROUND AND OBJECTIVE: Urinary tract infection (UTI) is a common bacterial infection during childhood. This article reports on a technical review investigating the management of UTI to inform the development of an updated clinical practice guideline (CPG) by the American Acade...

Burden of chronic postsurgical pain after caesarean delivery on maternal quality of life: a systematic review

Summary Introduction Chronic postsurgical pain after caesarean delivery is an important cause of postpartum morbidity, yet its impact on maternal quality of life has not been comprehensively synthesised. The aims of this systematic review were to evaluate the impact of chronic po...

Distinct clinical patterns of preterm infants vulnerable to intestinal injury identified by unsupervised clustering

BACKGROUND: Current necrotizing enterocolitis (NEC) diagnostic criteria fail to capture the full spectrum of intestinal injury. We aimed to identify diagnosis-independent clinical patterns of intestinal injury among vulnerable very low birth weight (VLBW) infants using unsupervis...

Implementing Community-Based Model-Driven Decision Support to Reduce Overdose Deaths: Lessons Learned at Study Midpoint

The overdose crisis continues to be a critical public health challenge in the United States and elsewhere. While funding has been provided at the federal, state, and municipal levels, implementation of strategies to address overdose is accomplished at the county level in most sta...

Deformable discoidal polymeric nanoconstructs: Design principles, therapeutic applications, and translational perspectives

Abstract Deformable Discoidal Polymeric Nanoconstructs (DPN) represent a biomimetic drug-delivery platform designed to overcome the limitations of conventional spherical nanoparticles. Their discoidal geometry, tunable deformability, and PLGA/PEG-based composition promote vascula...

Code-multiplexed multi-frequency impedance cytometry with a unified deep-unfolding network

Impedance flow cytometry (IFC) is a label-free, single-cell measurement technique that captures biophysical properties beyond traditional biochemical markers. Code-multiplexing allows parallelization of IFC with simple hardware but requires advanced signal processing algorithms t...

Clinical Prediction With Time-Varying Predictors in Pediatric Hospital Medicine

Clinical prediction models traditionally rely on measurements obtained at a single time point to estimate risk and guide management. However, the clinical status of hospitalized children often evolves during admission, and time-varying measurements obtained over the course of hos...

The contemporary role of stereotactic radiosurgery for surgically inoperable cerebral arteriovenous malformations

Surgically inoperable cerebral arteriovenous malformations (AVMs), including deep-seated, large, and eloquently located lesions, remain difficult to manage because the cumulative risk of hemorrhage must be balanced against the morbidity of curative microsurgery. Contemporary ster...

Conceptual growth curves of oropharyngeal soft tissues and craniofacial skeletal structures: clinical implications for pediatric airway management

Abstract Background Pediatric obstructive sleep apnea (OSA) is closely linked to the growth and interaction of upper airway soft tissues. The relevance of Scammon’s classical growth curves to site-specific oropharyngeal development has been called into question, despite the fact...

Modified radiation lobectomy as a bridge to curative surgery: tumor response, future liver remnant hypertrophy, and surgical outcomes

Abstract Background Few studies support modified radiation lobectomy (mRL) as a bridge to curative resection. This retrospective study reviews outcomes after mRL. Methods Patients with primary hepatic tumors undergoing mRL 90 Y radioembolization to grow the future liver remnant (...

Toward actionable biomarkers in psychiatry: a collaborative roadmap for precision clinical trials. An ACNP position paper

Abstract Psychiatric drug development remains constrained by diagnostic heterogeneity, insufficient and inconsistent drug response, high placebo response rates, and the absence of validated biomarkers that can reliably guide patient stratification, trial design, and regulatory de...

Time to diagnosis of acute kidney injury and its predictors among outborn neonates in India: a competing-risk analysis of tele-ICU network data (2022–2024)

Background There is limited data on neonatal acute kidney injury (AKI) from resource-constrained settings. In this study, we describe time to AKI diagnosis and its predictors among neonates born outside the treating hospital (outborn) in India, accounting for competing events lik...

COVID-19 lockdown and coverage of maternal health and nutrition care in rural West Bengal, India: a single interrupted time-series analysis

Abstract While COVID-19 lockdowns globally disrupted healthcare, the extent of changes in India’s maternal health and nutrition services coverage in rural settings requires further empirical investigation. Utilizing data from 57,371 pregnancies recorded between January 2012 and D...