Southern Medical University

Interpretable machine learning model for predicting the ICU readmission of patients after coronary intervention

To develop and validate an interpretable machine learning (ML) model integrated with inflammatory indicators for predicting ICU readmission in patients after coronary intervention (PCI/CABG). We used retrospective data from MIMIC-IV (training, 2196 patients) and MIMIC-III (extern...

Effects of post drill specification, preparation depth and adjacent tooth status on the scanning trueness of post space: an in vitro study

Abstract Background The indication for direct intraoral scanning of post spaces should be guided by the post drill. This study evaluated the influence of drill specifications, preparation depth, and the presence or absence of bilateral adjacent teeth on the scanning trueness of p...

Engineered Hierarchical Porosity in Three-Dimensional-Printed Hydrogel Scaffolds Enhances Mesenchymal Stem Cell Therapy for Chronic Diabetic Wounds

Abstract Unhealing chronic diabetic wounds is a major clinical challenge, as it is rooted in the complex pathological microenvironment, including neuropathy, angiopathy, and chronic inflammation. Traditional treatment methods cannot fundamentally solve these problems. Inspired by...

Development and benchmark validation of PubChat for PubMed-grounded multilingual biomedical literature retrieval

The rapid growth of biomedical literature has rendered traditional systematic reviews unsustainable. Although large language models (LLMs) offer automation potential, citation fabrication and unreliable evidence discrimination remain critical barriers. Here, using PubChat as a Pu...

52‐week ivarmacitinib in moderate‐to‐severe atopic dermatitis: A phase 3 trial

BACKGROUND: Ivarmacitinib, an oral JAK1 inhibitor, improved efficacy outcomes versus placebo at Week 16 in a phase 3 trial in patients with moderate-to-severe atopic dermatitis (AD). OBJECTIVES: To describe efficacy and safety outcomes through Week 52. METHODS: In this multicentr...

Hypoxia-induced m6A epitranscriptomic remodeling regulates gene expression in dental pulp stem cells: a combined MeRIP-seq and RNA-seq study

Dental pulp stem cells (DPSCs) are essential for regenerative endodontics. However, their survival and function are often challenged by the physiological hypoxic environment of the dental pulp. While N6-methyladenosine (m6A) modification is a critical post-transcriptional regulat...

Motivation, engagement, and perceived competence gains in competition-based medical education: a theory-informed structural equation modeling study

Competition-based learning is increasingly used in medical education to promote active participation, innovation, and collaborative problem solving. However, less is known about how students’ participation motivation, engagement, perceived competence gains, and satisfaction are r...

Crosstalk Between CTSB + Glioblastoma Cells and S100A10 + Macrophages: A Self‐Reinforcing Circuit Promotes Immune Evasion and Limits Response to Immunotherapy

ABSTRACT Background : Glioblastoma (GBM) establishes a highly immunosuppressive microenvironment through intricate molecular dialogues with tumor‐associated macrophages (TAMs), contributing to immunotherapy resistance. Methods : We integrated advanced biological network analyses...

Targeted microglial ROS-scavenging alleviates neuroinflammation and cognitive deficits via restoration of the 2-AG/CB2R signaling axis in schizophrenia

Cognitive impairment in schizophrenia is inadequately treated. The molecular link between oxidative stress and neuroinflammation in its pathophysiology remains unclear. We measured CB2R in circulating microglia‑derived exosomes from schizophrenia patients and healthy controls. In...

Candidate role of ADAMTS2 in regulating keratinocyte apoptosis via indirect NF-κB modulation in life-threatening PD-1 inhibitor-induced TEN-like cutaneous toxicity

Abstract Toxic epidermal necrolysis-like (TEN-like) immune-related cutaneous adverse event (ircAE) induced by programmed death 1 (PD-1) inhibitors is life-threatening; however, its pathogenesis remains unclear. This study aimed to dynamically characterize molecular signatures and...

Efficacy and Safety Analysis of Single‐Port Robotic Assisted Cholecystectomy Using a Novel Surgical Platform: A Bicentre, Single‐Arm, Prospective Phase II Clinical Study

ABSTRACT Background Single‐port robotic cholecystectomy offers minimally invasive benefits. This trial evaluated the feasibility and safety of a novel system, MicroPort SA‐1000. Methods In this dual centre, single‐arm, prospective study, eligible patients underwent single‐port ro...

Non-linear associations of plasma 25-hydroxyvitamin D with serum homocysteine and hyperhomocysteinemia in Chinese adults: a cross-sectional study

Abstract Background Plasma 25-hydroxyvitamin D [25(OH)D] deficiency and elevated homocysteine (Hcy) levels are both well-established risk factors for cardiovascular disease (CVD). However, the relationship between 25(OH)D and Hcy remains unclear. To explore the association betwee...

Clinical practice guidelines for nephrotic syndrome: systematic assessment of their quality and the concordance between certainty of evidence levels and strength of recommendations

Clinical practice guidelines (CPGs) aim to provide appropriate clinical practice recommendations based on available evidence while acknowledging existing gaps and uncertainties. However, the quality of CPGs for nephrotic syndrome (NS) remains unknown, and the distribution of evid...

Evaluating global clinical trials and development trends of antibody-drug conjugates

Antibody-drug conjugates (ADCs) represent a breakthrough in tumor-targeted therapy, showing promise in both solid tumors and hematological malignancies. By 1 September 2025, more than 370 ADC candidates had entered clinical development, 17 unique products had received at least on...

Spatial distribution, clustering patterns, and economic burden of comorbidities among hospitalised pulmonary tuberculosis patients in Guangdong province: a spatial epidemiological study based on inpatient big data

Background: Comorbidities may complicate the treatment of pulmonary tuberculosis and exacerbate both the clinical and economic burden. We aimed to examine comorbidity patterns, spatial clustering, and economic burden in hospitalised pulmonary tuberculosis (PTB) patients in Guangd...

Sequential Integration of Microenvironment Regulation Utilizing Aggregation‐Induced Emission Luminogen‐Based Carbon Dots for Diabetic Wound Treatment

Effective management of diabetic wound healing remains challenging due to the complex wound microenvironment, characterized by persistent infections and inflammation, as well as obstacles in tissue repair, including impaired extracellular matrix (ECM) remodeling and re-epithelial...

Trilobatin, a Natural Dihydrochalcone, Stabilizes Nrf2 to Protect the Heart from Angiotensin II–Induced Oxidative and Hypertrophic Stress

Aims: Oxidative stress–driven cardiac remodeling is a key pathological feature of heart failure and hypertensive heart disease, yet effective antioxidant therapies remain limited. This study aimed to determine whether the natural dihydrochalcone trilobatin (Tri) protects against...

A phase III clinical trial of PXT3003 in Chinese patients with Charcot-Marie-Tooth disease type 1A

Charcot-Marie-Tooth disease type 1A (CMT1A) is the most common inherited peripheral neuropathy and currently lacks disease-modifying therapy. PXT3003, a low-dose oral combination targeting PMP22 overexpression, has shown efficacy in two trials, while one recent confirmatory trial...

LDL-C–stratified residual lipoprotein(a) and inflammatory risk after acute myocardial infarction among patients with prior statin use

Abstract Background Patients can experience acute myocardial infarction (AMI) despite documented prior statin exposure, indicating persistent residual cardiovascular risk. The prognostic relevance of lipoprotein(a) [Lp(a)] and residual inflammation in this setting remains unclear...

A programmed sequential organelle-targeted nanoattack strategy for cGAS-STING hyperactivation and potentiated systemic cancer immunotherapy

Cancer immunotherapy is hindered by insufficient immunogenic cell death (ICD) and suboptimal cGAS-STING activation. While organelle-targeted therapies hold promise, conventional treatments often fail because single-target attacks are neutralized by tumor buffering networks, where...