Southern Medical University

Decomposition analysis of the disparities in depressive symptoms among middle-aged and older adults between urban and rural areas in China: adverse childhood experiences are a contributing factor

Depression is a major public health concern in China, with growing urban-rural disparities. This study aimed to examine how adverse childhood experiences (ACEs) and other factors contribute to these disparities. Data were drawn from 7979 adults aged ≥45 years from the China Healt...

Sacral Neural Crest‐Derived Extracellular Vesicles Promote Pelvic Ganglion Repair Through Anti‐Pyroptotic Effects Involving ANXA1–FPR2 Signaling

ABSTRACT Pelvic autonomic nerve injury is a major cause of postoperative bowel dysfunction, yet effective strategies for restoring damaged pelvic ganglia remain lacking. Here, we demonstrate that extracellular vesicles derived from human pluripotent stem cell‐derived sacral neura...

Skeletal Muscle DPT Ameliorates Obesity and Metabolic Dysfunction via the PERK/eIF2α/ATF4-GDF15 Axis

Skeletal muscle plays a pivotal role in maintaining metabolic homeostasis by acting as a primary site for glucose disposal and insulin-mediated energy use. Here, through RNA sequencing of skeletal muscle from individuals with normal weight versus obesity, we identified that the e...

Baseline anti-PLA2R antibody titer predicts treatment response and renal outcomes in rituximab-treated membranous nephropathy

Abstract Introduction As rituximab (RTX) has become a first-line therapy for idiopathic membranous nephropathy (IMN), identifying baseline predictors of treatment response is crucial for personalized management. This study was conducted to evaluate whether baseline anti-PLA2R tit...

Joint trajectories and associated characteristics of postpartum depressive and anxiety symptoms: a longitudinal study

Postpartum depressive and anxiety symptoms are common postpartum mental health issues, and these symptoms often co-occur. However, previous studies have primarily analyzed them separately, with limited evidence regarding their joint developmental trajectories and associated chara...

Senescent cancer-associated fibroblasts secrete Tenascin-C to promote tumor progression in high-grade serous ovarian cancer

Cellular senescence is a hallmark of cancer, and senescent cancer-associated fibroblasts (seneCAFs) contribute to tumor progression across multiple malignancies. However, how seneCAFs promote high-grade serous ovarian (HGSOC) remains unclear. We integrated public single-cell RNA...

Development and validation of the Beliefs in Social Anxiety Scale (BIAS) for Chinese socially anxious adults and adolescents

BACKGROUND: Maladaptive social beliefs play a pivotal role in the development and maintenance of social anxiety; however, existing measures have limited cultural adaptability for Chinese populations. Therefore, this study developed and validated the Beliefs in Social Anxiety Scal...

Analysis of care needs for primary caregivers of premature infants at home based on the Kano model: A cross-sectional study

Objective This study applied the Kano model to analyze the attributes of care needs among primary caregivers of discharged premature infants(up to 6 months post discharge), identify priority needs, and provide a foundation for developing targeted nursing service plans. Methods Be...

COPD/OSA phenotypes and inpatient outcome patterns among primary total hip arthroplasty hospitalizations: a national inpatient sample study, 2016–2022

Chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA) are common among patients undergoing total hip arthroplasty (THA), but whether COPD-only, OSA-only, and coexisting COPD + OSA define distinct inpatient risk phenotypes remains unclear. This retrospecti...

Engineering a Single-Plasmid Dual-Pigment Escherichia coli Biosensor for Simultaneous Colorimetric Detection of Pb(II) and Hg(II)

Abstract This work presents an engineered single-plasmid, dual-pigment whole-cell biosensor for simultaneous colorimetric detection of Pb(II) and Hg(II). To address the challenge of signal interference in cocontaminated environmental samples, a Pb(II)-responsive PbrR regulatory m...

Esketamine’s therapeutic effect on anhedonia in adolescents: a post-hoc of a randomized controlled trial

Abstract Background Anhedonia, a prominent symptom of major depressive disorder (MDD), severely impairs patients’ quality of life and is challenging to treat. Although esketamine has shown potential in treating anhedonia in adult treatment-resistant MDD, its effects on adolescent...

Age-Associated Differences in Facial Skin Structure in Chinese Women: a Cross-Sectional Study

Facial skin aging is a process leading to structural degradation and visible phenotypical changes. Prior studies examined age-related skin parameters and suggested accelerated changes occurring in the early 30s, yet precise timing remains insufficiently defined, and few assessed...

Phase separation of PHLDB2 promotes lung adenocarcinoma progression through FLNA stabilization and ERK activation

Lung adenocarcinoma (LUAD) is the most common histological subtype of lung cancer, but the phase separation-related mechanisms that support its progression remain poorly defined. By integrating phase separation-related gene profiling with prognostic modeling, we identified PHLDB2...

Structural Control of Stromal‐Immune Coupling by COL24A1 Underlies Pregnancy Maintenance

ABSTRACT Successful pregnancy requires dynamic extracellular matrix (ECM) remodeling at the maternal‐fetal interface, yet whether individual collagen subtypes actively regulate this process remains unknown. Here, collagen type XXIV alpha 1 chain (COL24A1), a uterine‐enriched fibr...

Placenta-Related PEG10 Inhibits mRNA Decay to Promote Glucose Metabolism and Tumor Progression in Hepatocellular Carcinoma

Abstract Tumors display marked similarities with embryos, exploiting embryonic developmental programs. Beyond the embryo, the placenta also shares features with malignant tumors, such as invasion, immune evasion, and rapid nutrient exchange, highlighting the need for mechanistic...

Incidence and Predictors of Complications After Transcatheter Aortic Valve Implantation According to VARC‐3 Criteria: A Systematic Review and Meta‐Analysis

BACKGROUND: Despite continuous advancements in devices and techniques, transcatheter aortic valve implantation remains associated with complications impacting outcomes. In 2021, the Valve Academic Research Consortium (VARC) introduced the VARC-3 criteria to better classify proced...

Oligosaccharides from Dendrobium officinale Ameliorate Metabolic Dysfunction in db/db Mice by Modulating Gut Microbiota, Short-Chain Fatty Acid Production, and Intestinal Barrier Integrity

Abstract Functional oligosaccharides have attracted attention as dietary interventions for type 2 diabetes mellitus (T2DM). However, the effects of oligosaccharides derived from Dendrobium officinale (DOO1) in T2DM remain unclear. This study evaluated the effects of DOO1 on metab...

Effectiveness and Safety of Fixed‐Dose Combination Metformin and Empagliflozin in Type 2 Diabetes: A Prospective, Multicenter, Real‐World Study From China

BACKGROUND: This study assessed the real-world effectiveness and safety of a fixed-dose combination (FDC) of metformin and empagliflozin in Chinese patients with type 2 diabetes mellitus (T2DM). METHODS: This prospective, multicenter, real-world study enrolled consecutive patient...

CD147 is associated with NF-κB activation during the post-traumatic immune response in a murine trauma model

Abstract Extracellular matrix metalloproteinase inducer (CD147) has been proven to play a crucial role in a variety of inflammatory diseases but has not yet been investigated in trauma. The aim of the study was to investigate the role of CD147 in a murine model of trauma and hemo...

Supramolecular Zinc–Polyphenol Coordination Assemblies Mitigate Colonic Inflammation by Regulating Mucosal Barrier and Microbiome

ABSTRACT To overcome the poor bioavailability and environmental instability of physical polyphenol co‐assemblies while maximizing their preventive efficacy, the authors engineered carrier‐free, metal–phenolic coordination nanoparticles (ZnCA NPs) utilizing divalent zinc (Zn 2+ )...