Southern Medical University

Severe adhesive probability score (SAPS): an imaging scoring system for predicting adherent perinephric fat in patients with infectious nonfunctional kidney

To identify and validate clinical and radiological predictors of perirenal fat adherence and develop a prediction model for perirenal fat adhesions in infectious nonfunctioning kidneys. A retrospective study was conducted on 277 patients who underwent robotic-assisted or laparosc...

Integrative single-cell sequencing and machine learning analyses identify chronic inflammation and cancer-associated fibroblast subsets as drivers of adverse outcomes in ovarian cancer

Background Ovarian cancer remains the deadliest gynecological malignancy, with neoadjuvant chemotherapy (NACT) often leaving residual fibroblast-enriched disease. Methods Single-cell RNA sequencing data from 64,097 cells were analyzed using Seurat (v4.1.3) with Harmony batch corr...

Using the simple telegraph model to decipher transcriptional burst regulation across genome-wide data.

). Their interdependent dysregulation accelerated HCM. This study establishes the simple telegraph model as a scalable framework linking transcriptional burst dynamics to cell fate and pathology.

Value of spectral CT in differentiating post-treatment recurrence/residual tumor from inflammatory fibrosis in nasopharyngeal carcinoma

This prospective, single-center pilot study aims to investigate the potential value of spectral computed tomography (CT) in differentiating post-treatment recurrence/residual tumor from inflammatory fibrosis in patients with Nasopharyngeal Carcinoma (NPC). This prospective study...

Resveratrol reprograms ARG1⁺ microglia to remodel the immunosuppressive microenvironment in primary CNS lymphoma via secretion cytokine

Abstract Primary central nervous system lymphoma (PCNSL) is a CNS-restricted lymphoma with poor prognosis. Despite sharing pathological features with systemic diffuse large B-cell lymphoma (DLBCL), PCNSL exhibits unique molecular mutation patterns, highlighting the critical role...

Chitosan Microspheres Incorporating Doxorubicin-Loaded Mesoporous Silica Nanoparticles as a Potential Multifunctional Platform for Postoperative Osteosarcoma Management

Abstract Osteosarcoma remains a major clinical challenge owing to its high recurrence rate, metastatic potential, and the frequent need for postoperative bone reconstruction. Here, we report a multifunctional platform consisting of doxorubicin-loaded mesoporous silica nanoparticl...

Comparative efficacy and safety of PCSK9 inhibitors for lipoprotein(a) reduction: a systematic review and network meta−analysis

Abstract Introduction Lipoprotein(a) [Lp(a)] is a genetically determined cardiovascular risk factor that is largely unaffected by statins. Although PCSK9 inhibitors can lower Lp(a), comparative evidence among agents is limited. Methods We conducted a systematic review and frequen...

Adolescent environmental enrichment prevents early-life stress-induced schizophrenia-like phenotypes via restoration of CREB-BDNF-TrkB signaling

Early-life stress (ELS) is a major environmental risk factor for schizophrenia, yet effective preventive strategies targeting its neurodevelopmental consequences remain limited. Here, we show that adolescent environmental enrichment (EE) prevents the emergence of schizophrenia-li...

A MultitaskLarge Reasoning Model for Molecular Science

Abstract Artificial intelligence in molecular science must move beyond pattern recognition toward chemically valid and interpretable reasoning. We present a task-adaptive large reasoning model that integrates chemical knowledge through a synergistic multispecialist architecture,...

An explainable biomedical foundation model via large-scale concept-enhanced vision–language pretraining

Artificial intelligence for medical imaging is required to be accurate and interpretable to clinicians. However, current multimodal biomedical foundation models often prioritize performance over explainability. Here we present ConceptCLIP, an explainable biomedical foundation mod...

Integrated single-cell and functional analyses define fatty acid oxidation activation associates with poor prognosis in oral squamous cell carcinoma

<title>Abstract</title> Fatty acid oxidation (FAO) activation was reported to promote tumor progression, yet its role in oral squamous cell carcinoma (OSCC) remains incompletely understood. Here, we found that FAO was significantly activated in both OSCC tissue biopsies and OSCC...

Plant-based diet and risk of cognitive decline among older adults: a community-based prospective cohort study

Background: Diet serves as a modifiable risk factor for cognitive decline, yet evidence on plant-based diets and cognitive ageing remains limited. We examined the association between plant-based diets and cognitive decline.Methods: A total of 6,721 participants from the Chinese L...

Association between high triglyceride-glucose index status and one-year all-cause mortality in patients with thoracic aortic aneurysm: a MIMIC-IV cohort study

The triglyceride-glucose (TyG) index is widely used as a surrogate marker of insulin resistance and has been associated with a range of adverse cardiovascular outcomes. However, its role in the longer-term prognosis of patients with thoracic aortic aneurysm (TAA), particularly on...

Phase-specific relationships between cognitive function and life-space mobility in patients with ischemic stroke: implications for geriatric rehabilitation

Based on the Chronic Illness Trajectory Framework (CITF), this study aims to explore the longitudinal trajectories and dynamic reciprocal relationships between cognitive function and life-space mobility in older patients with ischemic stroke (IS) during a 1-year post-discharge fo...

Integrated proteomic, transcriptomic, and epigenomic profiling identifies SRA1 as a novel therapeutic target for postpartum depression

Postpartum depression (PPD) is among the most common complications of childbirth, and identifying novel treatments is vital. We aimed to identify potential drug targets for PPD by integrating the plasma proteome, transcriptome and epigenome. We designed a comprehensive analysis p...

YAP delactylation enhances therapy resistance in renal cell carcinoma

Abstract Lactylation is a novel lysine acylation modification, and its function and exact mechanisms remain unclear. The responsiveness to combined targeted and immunotherapy continues to be a major challenge in cancer treatment. Here, we discovered that lysine lactylation (Kla)...

Associations of early-life exposure to PM2.5 mass and its components with childhood anemia: A cross-sectional study in China, India, and Africa

Childhood anemia remains a major public health concern, but evidence regarding the associations of early-life exposure to PM 2.5 mass and its components with childhood anemia across regions remains limited. We conducted a cross-sectional study of 449,894 children under 5 years fr...

WDR4-mediated m7G modification of ZBP1 mRNA drives peri-implantitis by promoting M1 macrophage polarization

Abstract Objective Macrophage polarization exerts a vital role in the progression of peri-implantitis. RNA methylation serves as an important regulator of macrophage polarization. However, reports on the role of N7-methylguanosine (m7G) regulators in peri-implantitis are scarce....

Solute carrier family 25 member 32 promotes the proliferation of esophageal squamous cell carcinoma and is associated with immune infiltration

Abstract Esophageal squamous cell carcinoma (ESCC) is a highly invasive and poorly prognosed malignant tumor of the digestive tract. Currently, there are no effective molecular classification markers for ESCC. This study screened out the key gene SLC25A32 based on mitochondrial-r...

Case report of rare complication: unilateral chest wall hematoma after intracranial aneurysm embolization

Unilateral chest wall hematoma is a rare but life-threatening cause of shock following endovascular procedures. We report a case of refractory hypotension and unilateral chest wall swelling in the post-anesthesia care unit, which was initially suspected to be a tension pneumothor...