Southern Medical University

Macrophages in dental pulp: dynamic regulators of microenvironmental homeostasis and therapeutic targets in pulpitis

Abstract The dental pulp is a soft connective tissue enclosed by mineralized dentin, containing odontoblasts, dental pulp stem cells (DPSCs), fibroblasts, endothelial cells, nerves, and immune cells. Under physiological and pathological conditions, these cells collectively regula...

Case report of rare complication: unilateral chest wall hematoma after intracranial aneurysm embolization

Unilateral chest wall hematoma is a rare but life-threatening cause of shock following endovascular procedures. We report a case of refractory hypotension and unilateral chest wall swelling in the post-anesthesia care unit, which was initially suspected to be a tension pneumothor...

Comparative effects of semaglutide tirzepatide and retatrutide on renal fibrosis in UUO and aged mice

Chronic kidney disease is a major health burden. Given the therapeutic potential of GLP-1 receptor agonists (semaglutide, tirzepatide, and retatrutide) in diabetic nephropathy, we evaluated their anti-fibrotic and anti-inflammatory effects in non-diabetic renal fibrosis using HK-...

Ambient nitrogen dioxide and composition-specific risk of urolithiasis: a multicenter time-stratified case-crossover study

Background: Emerging evidence suggests that ambient air pollution and meteorological variation may trigger urolithiasis, but stone-composition–specific and lagged associations are poorly characterized.Methods: We conducted a multicenter, time-stratified case-crossover study in Gu...

Extinction-restraint intervention eradicates fear memory encoded in BLA engram cells via D2 receptor-mediated dopaminergic modulation from locus coeruleus

Abstract Despite undergoing exposure therapy, individuals with post-traumatic stress disorder (PTSD) frequently experience relapses when confronted with trauma reminders. This study examined the impact of extinction-restraint intervention (Ext-Res) in a PTSD-related fear relapse...

Structure-BasedDesign and Optimization of Onradivir-DerivedPB2 Inhibitors for the Treatment of Influenza A

Abstract Influenza A remains a major seasonal public health burden. With the approval of onradivir, PB2 has emerged as an attractive antiviral target due to its unique and conserved structural features. Herein, using onradivir as the lead, we employed bioisosteric replacement str...

Modification GeneKnockout Diversifies Piericidinsfrom the Marine-Derived Streptomyces psammoticus SCSIO NS126

Abstract Piericidins are α-pyridone agricultural antibiotics produced by actinomycetes. To improve their yield and structural diversity from marine-derived Streptomyces psammoticus SCSIO NS126, this study employed homologous recombination to achieve large-fragment knockout of mod...

Intermittent fasting promotes plaque regression and activates the BMAL1–MERTK efferocytosis axis

Abstract Background Atherosclerotic cardiovascular disease can progress despite intensive lipid lowering, highlighting the need to identify local mechanisms that remodel established plaques. Intermittent fasting may engage metabolic, circadian, and immune pathways relevant to thi...

ABHD11-Mediated mtDNA Transcription Restored Mitochondrial Function to Attenuate Cardiomyocyte Ferroptosis After Myocardial Infarction

BACKGROUND: Cardiomyocytes exhibit marked susceptibility to ferroptosis after myocardial infarction (MI), rendering ferroptosis inhibition a promising therapeutic strategy to mitigate ischemic myocardial injury. Although mitochondrial dysfunction is recognized as a core driver of...

Altered circulating blood microbiota in unexplained recurrent spontaneous abortion

The etiology of unexplained recurrent spontaneous abortion (URSA) remains poorly understood. Emerging evidence implies that URSA is closely related to dysbiosis of the symbiotic microbiota, while the characteristics of blood microbiome in URSA remain unclear. In the present preli...

Clinical assessment and management of bone health in non-metastatic breast cancer patients: a best practice implementation project

INTRODUCTION: Non-metastatic breast cancer survivors are at higher risk of developing musculoskeletal diseases, including bone metastases, bone loss, pain, osteoporosis, and fractures. Bone health issues may affect patients' quality of life and even reduce survival. Effective ass...

Top2a complexes with Trim28 to orchestrate stemness of embryonic stem cells and tumorigenesis

Type II topoisomerase α (Top2a) is crucial for maintaining the stemness of embryonic stem cells (ESCs) and is upregulated in various human cancers, yet the mechanisms underlying its cell type-specific functions remain elusive. Here, using an unbiased proteomic approach, we discov...

NADPH-cytochrome P450 reductase mediates P450-dependent metabolic resistance to deltamethrin in Aedes albopictus

The cytochrome P450 monooxygenase system is a key detoxification pathway involved in insecticide metabolism in insects and plays a central role in the evolution of insecticide resistance. NADPH-cytochrome P450 reductase (CPR), a crucial electron transfer partner in cytochrome P45...

Yield-point detection can improve the mechanical performance of cancellous bone screws

Appropriate torque applied to screws is an insurance for strong and durable fracture fixation. We compared the mechanical characteristics of four types of bone screws during insertion to facilitate the development of an optimal screw torquing strategy. Bone screws were inserted i...

Spatiotemporal trends and multilevel determinants of coexisting maternal and child undernutrition in Nepal: evidence from Nepal Demographic and Health Survey 2006–2022

Abstract Background Coexisting maternal and child undernutrition (CMCU) is a critical aspect of intergenerational malnutrition. The evidence on its epidemiological trends and spatial distribution remains limited in Nepal. This study investigated the temporal trends, determinants,...

Systemic influences on orthodontic tooth movement: mechanisms and clinical implications

Orthodontic tooth movement (OTM) is a complex biological process involving bone remodeling, which can be significantly affected by systemic diseases and systemic factors. This review comprehensively examines how systemic conditions such as diabetes mellitus, thyroid dysfunction,...

Cross-KingdommiR5054 Delivery via Polygonum cuspidatum -Derived Nanoparticles Enhances Burn Wound Healingby Regulating Microvascular Environment

Abstract Deep partial-thickness burns are characterized by a self-perpetuating cycle of oxidative stress and inflammation that severely impedes healing. Here, we identified Polygonum cuspidatum-derived nanoparticles (PDNs) as a multifaceted nanotherapeutic that breaks this pathog...

Macrophage-to-myofibroblast transition-derived itaconate promotes bone metastasis in lung cancer through targeting of HSPA8

Abstract Lung cancer bone metastasis carries a poor prognosis, yet the metabolic determinants driving tumour–stroma crosstalk remain largely elusive. Despite extensive investigations into itaconate, a prominent immunometabolite implicated in macrophage polarization, the precise m...

Associations Between the Inflammation Burden Index and Cardiovascular–Kidney–Metabolic Syndrome: A Cross-Sectional Study Based upon the NHANES Database

Background: Cardiovascular–kidney–metabolic (CKM) syndrome is a systemic disorder manifested as the interconnected dysregulation of cardiovascular disease, chronic kidney disease, and metabolic abnormalities. Systemic inflammation was identified as an important contributor to CKM...

2-Ethylhexyl Diphenyl Phosphate (EHDPP) Induces Hepatic Expression of Cytochrome P450s, Liver Damage, and Genotoxicity in Mice

As a commonly present organophosphorus flame retardant and persistent organic pollutant, 2-ethylhexyl diphenyl phosphate (EHDPP) has been observed to be genotoxic in cultured human hepatoma (HepG2) cells which depends on CYP activities. Yet, its impacts on hepatic Cyp expression,...