Southern Medical University

Supramolecular Zinc–Polyphenol Coordination Assemblies Mitigate Colonic Inflammation by Regulating Mucosal Barrier and Microbiome

ABSTRACT To overcome the poor bioavailability and environmental instability of physical polyphenol co‐assemblies while maximizing their preventive efficacy, the authors engineered carrier‐free, metal–phenolic coordination nanoparticles (ZnCA NPs) utilizing divalent zinc (Zn 2+ )...

Regulatory T cells in liver diseases: roles and therapeutic targeting

The liver is an immune-tolerogenic organ in which coordinated interactions between resident and infiltrating immune cells maintain hepatic and systemic homeostasis. Disruption of this balance can lead to chronic inflammation, fibrogenesis, infection, and malignant transformation,...

Metabolic reprogramming for CAR-T cell therapy: advances and perspectives

Chimeric antigen receptor T cell (CAR-T) therapy has redefined the therapeutic landscape of hematological malignancies, yet its efficacy in solid tumors remains constrained by rapid functional attrition. Metabolic fitness serves as the primary arbiter of CAR-T cell fate, orchestr...

Stage-specific nanotherapeutics for glaucoma target elevated IOP, impaired aqueous-humor outflow, RGC degeneration, and fibrotic inflammation during postoperative wound healing

Glaucoma is a chronic neurodegenerative disease in which elevated intraocular pressure (IOP), impaired aqueous-humor outflow, retinal ganglion cell (RGC) degeneration, and postoperative fibrosis may coexist or predominate at different stages. Conventional therapies are effective...

Emotional distress and pathological response to neoadjuvant immunotherapy in locally advanced gastric cancer: a multicentre retrospective cohort study

To investigate the association between emotional distress (ED) and pathological response to neoadjuvant immune checkpoint inhibitor (ICI)-based therapy in patients with locally advanced gastric cancer (GC). In this retrospective cohort study (April 2022–December 2024), 129 advanc...

Barriers and facilitators of weight management in overweight and obese individuals: a qualitative study using the CFIR framework

Obesity is a major global health issue linked to chronic diseases. Maintaining a healthy body weight is an effective measure for preventing related disease but often faces implementation challenges. This qualitative study aims to identify facilitators and barriers to weight manag...

Surface-displayed cholesterol enhances penetration and anti-tumor activity of a platinum nanodrug by targeting NPC1L1-expressing cancer associated fibroblasts

Transcytosis-mediated delivery effectively enhances tumor penetration of nanodrugs but is less efficacious in stroma-rich tumors. Cancer associated fibroblasts (CAF) can represent a physical barrier for drug delivery in tumor cells. Herein, by selectively targeting NPC1L1-cancer...

Supramolecular Salicylic Acid Chemical Peeling Combined with Supramolecular Active Zinc for Malassezia Folliculitis: Efficacy and Safety from a Multicenter, Single-Arm Trial

Traditional antifungal therapy for Malassezia folliculitis (MF) is often associated with high recurrence rates and limited long-term options. This study evaluated the efficacy and safety of 30% supramolecular salicylic acid (SSA) combined with supramolecular active zinc (SAZ) in...

Vaginal microbiome and metabolome profiling identifies candidate signatures associated with persistent high-risk HPV infection

Abstract The role of vaginal microbiota dysbiosis in the progression of human papillomavirus (HPV) infection is increasingly recognized. Yet, the factors determining why only a minority of infections persist and evolve into clinically significant disease remain poorly defined. Fr...

Biomechanical comparison of three C2 subfacetal screw trajectories: a finite element analysis with reference to established posterior atlantoaxial fixation techniques

C2 subfacetal screw fixation has emerged as a crucial alternative for atlantoaxial instability when a high-riding vertebral artery (HRVA) precludes the use of conventional C2 pedicle screws. However, a comprehensive finite element analysis focusing on the biomechanical variances...

Tolerogenic dendritic cells modulate macrophage inflammatory response in Ulcerative colitis: role of IL-1RN

Abstract Background Ulcerative colitis (UC) is a chronic, idiopathic inflammatory disease whose pathogenesis involves various immune cells. Measures that suppress the inflammatory responses of intestinal macrophages are considered crucial for improving ulcerative colitis. In rece...

An integrated immune-related signature reveals prognostic and immune–microbiome–genomic interactions in head and neck squamous cell carcinoma

Background Head and neck squamous cell carcinoma (HNSCC) is characterized by substantial biological diversity and heterogeneous clinical outcomes. Immune-based therapies have improved treatment options for some patients; however, reliable biomarkers capable of accurately defining...

Longitudinal assessment of early childhood caries increment and exploratory dmft progression among children of medical college employees

Abstract Background This study aimed to evaluate the progression of early childhood caries (ECC) and identify its associated risk factors among preschool children of medical college employees. Methods From October 2021 to March 2023, baseline and two follow-up examinations were c...

Nanoplastic uptake through ROS-induced plasma membrane damage exacerbates renal fibrosis under hypoxia

Exposure to environmental nanoplastics and renal hypoxia are two commonly encountered detrimental factors for human health. However, their combined effects on the kidney and the underlying mechanisms remain poorly understood. This study aimed to determine (1) whether hypoxia infl...

Decoding the adipose-fibrotic axis: multi-organ mechanisms, crosstalk networks and emerging therapeutic targets

Adipose tissue is a dynamic endocrine and immunometabolic organ that shapes fibrotic remodeling within and beyond its anatomical boundaries. This review synthesizes evidence across skin, heart, liver and intestine to articulate a unifying adipose-fibrotic axis. We highlight depot...

Induction of transferrin receptor 1-mediated ferroptosis by ultrasound-triggered microbubble destruction sensitizes glioblastoma to radiotherapy

Abstract Ultrasound-triggered microbubble destruction (UTMD), a non-invasive technique, has been proposed as a promising means of improving the efficacy of radiotherapy against glioblastoma (GBM); however, the underlying mechanisms remain to be fully clarified. Here, UTMD was sho...

Integrated multi-omics decodes the AKI-to-CKD transition: from ensemble discovery to structure-guided translational targeting

The transition from acute kidney injury (AKI) to chronic kidney disease (CKD) constitutes a major global health burden. Identifying causal drivers remains challenging due to proteomic complexity and confounding biases. We aimed to construct a discovery framework to identify actio...

Common SAEs and their impact on the prognosis of children treated with the CCCG-ALL-2015 protocol: a retrospective multicentre Chinese study

This study was intended to evaluate common serious adverse events (SAEs) and analyze their effects on the prognosis of acute lymphoblastic leukemia (ALL) children. We retrospectively collected the data of 7640 consecutive ALL children with/ without SAEs who were enrolled in CCCG-...

Kidney fibrosis is mediated by GARP-restricted TGF-β activation in fibroblasts

TGF-β is a central driver of kidney fibrosis, a common pathological hallmark of chronic kidney disease (CKD). Initiation of TGF-β signaling requires not only its synthesis but also the conversion of latent TGF-β to its bioactive form. However, the mechanisms governing TGF-β activ...

Inhibition of Jaw Bone Marrow Mesenchymal Stem Cell Cuproptosis Attenuates Bone Loss in Apical Periodontitis via Suppressing the FoxO Signalling Pathway

ABSTRACT Aim Apical periodontitis (AP) is an infectious disorder characterized by periapical inflammation and alveolar bone destruction. Recent evidence suggests that cuproptosis, a distinctive form of copper‐regulated cell death, has been implicated in the regulation of bone los...