Southern Medical University

An Adaptive In SituBiointerfacial Armoring Platformfor Long-Term Gut Microbiota Modulation

Abstract Despite the immense potential against diverse chronic inflammatory and metabolic disorders, the clinical translation of microbial therapies is largely thwarted by the delivery challenges of live biotherapeutics. Probiotics often succumb to harsh gastrointestinal conditio...

Single‐Molecule Real‐Time Sequencing Reveals Hidden Diversity and Corrects Misdiagnosis in α‐Thalassemia

ABSTRACT Objectives Conventional methods for α‐thalassemia gene diagnosis, such as Gap‐PCR, are primarily designed for common deletions. However, their limitations in detecting complex rearrangements that maintain the total copy number of α‐globin genes can lead to misdiagnosis,...

Rhodium-Catalyzed C–H Functionalization Enabling Divergent Heterocycle Syntheses

Abstract Direct C–H bond functionalization represents a facile synthetic strategy that adheres to the principle of atom economy. Among a variety of metal catalysts, rhodium catalysts demonstrate distinctive advantages owing to their excellent reactivity. This account summarizes o...

Recent Advances in the Functionalization Design and Applications of Natural Polyphenols in Metal–Organic Frameworks

As naturally occurring bioactive molecules derived from plants, polyphenols exhibit significant potential for the functional modification and structural regulation of metal–organic frameworks (MOFs) due to their unique ortho-phenolic hydroxyl groups, excellent metal-coordinating...

METTL14-dependent N6-methyladenosine modification of FGF16 participates in IGFBP5 deficiency-enhanced angiogenesis.

A-FGF16 axis may offer novel therapeutic strategies for ischemic disease.

METTL14-dependent N6-methyladenosine modification of FGF16 participates in IGFBP5 deficiency-enhanced angiogenesis

Abstract N 6 -methyladenosine (m 6 A) RNA modification plays critical roles in physiological and pathological processes. Our prior study demonstrated that IGFBP5 expression is upregulated in the ischemic limb, whereas endothelial-specific IGFBP5 knockout (Igfbp5 EKO ) protects ag...

Thyroid function and hypertensive disorders of pregnancy: Insights from a sex‐specific cohort study, Mendelian randomization, and experimental validation

OBJECTIVE: To investigate the association of a history of hypertensive disorders of pregnancy (HDP) and a higher risk of cardiovascular disease using a sex-specific cohort study, bidirectional two-sample Mendelian randomization (MR), and in vitro experiments. METHODS: Multivariab...

Endothelial regulators in the infrapatellar fat pad of osteoarthritis revealed by integrative multi-omics and genetic causal inference

Osteoarthritis (OA) is a multifactorial degenerative joint disease involving multiple joint components, including the infrapatellar fat pad (IFP), whose role in OA pathogenesis remains poorly understood. In this study, we employed an integrative multi-omics strategy to delineate...