Southern Medical University

Inflammatory Biomarker Score and Asthma Risk: Longitudinal Evidence from Chinese and English Aging Cohorts

BACKGROUND: Asthma is a prevalent airway disease influenced by various factors. Despite the known association between inflammation and asthma, no study has systematically investigated the relationship between inflammatory scores (INS) and asthma risk. This study explored this lon...

Obstructive sleep apnea as a risk factor for postoperative complications in lumbar spine surgery: a nationwide inpatient sample database study

Obstructive sleep apnea (OSA) is a prevalent sleep-disordered breathing condition associated with systemic comorbidities; however, its specific impact on postoperative outcomes following lumbar spine surgery (LSS) remains under-characterized. This study aimed to determine the evo...

Phoenix Sepsis Score as a prognostic tool for mortality in immunocompromised children with sepsis and septic shock: a six-year study from a Thai referral center

Immunocompromised children with sepsis and septic shock face substantially higher mortality rates. This study aimed to evaluate the Phoenix Sepsis Score as a prognostic tool for mortality and to identify factors associated with mortality in immunocompromised children with sepsis...

Mechanosensitive epitranscriptomics in cancer: linking tumor mechanics, RNA modification, and immune escape

Solid tumors are mechanically abnormal ecosystems in which extracellular matrix stiffening, compressive stress, interstitial pressure, and aberrant fluid flow reshape cancer, stromal, and immune cell behavior. In parallel, the cancer epitranscriptome has emerged as a dynamic regu...

Cognitive function among COVID-19 survivors in the subacute phase during the epidemic of Omicron variant in China

Following the relaxation of pandemic control measures in China, the impact of coronavirus disease 2019 (COVID-19) on cognitive function in the Chinese population has not been investigated. Therefore, this study aimed to assess cognitive function and identify its risk factors in t...

Association between endothelial activation and stress index and all-cause mortality risk in cerebral infarction patients

Abstract Background Acute cerebral infarction (ACI) is a major cause of global morbidity and mortality, with endothelial dysfunction being a key factor in its pathophysiology. The Endothelial Activation and Stress Index (EASIX) is a novel biomarker reflecting endothelial injury a...

Automated Multimodal Correlative Registration for Organelle-Specific Elemental and Isotopic Imaging

Abstract Mapping the subcellular partitioning of therapeutics is important for understanding their trafficking, mechanisms of action, and off-target effects. NanoSIMS provides chemical images of labeled therapeutics, but assigning these signals to cellular structures requires cor...

Novel mutations of PIKFYVE identified in 322 sporadic cataract patients

BACKGROUND: PIKFYVE, a novel pathogenic gene causing congenital cataract, its association with sporadic cataracts has not been systematically investigated. This study aimed to explore PIKFYVE mutation profiles in major sporadic cataract subtypes. METHODS: We enrolled 322 sporadic...

An Apoptotic Body‐Mimetic Nanoagonist for Synergistic Diabetic Wound Immunotherapy

Diabetic skin injury (DSI), which are challenging to heal, contribute to global economic losses exceeding US$ 250 billion annually. The impaired healing process is primarily driven by severe local inflammation, excessive oxidative stress, and restricted angiogenesis, with dysfunc...

Immunomodulatory Amacstatins facilitate feeding and Rickettsia parkeri transmission by Amblyomma maculatum ticks

Ticks rely on salivary immunomodulators to sustain prolonged blood feeding and transmit pathogens, yet the protein effectors that mediate these processes remain incompletely defined. Here, we characterize three divergent cysteine protease inhibitors—Amacstatins—from the Gulf Coas...

Genetic prioritization and multi-omic characterization of GNS-associated thromboinflammatory signatures in venous thromboembolism

Venous thromboembolism (VTE) remains a major cause of cardiovascular morbidity and mortality. Beyond dysregulated coagulation, accumulating evidence implicates immune and inflammatory pathways in thromboinflammatory susceptibility. However, the genetic determinants of VTE and the...

Sprayable hydrogel loaded with engineered fusion cellular vesicles for cancer recurrence suppression

Surgical resection often leaves residual lesions that lead to tumor recurrence and high mortality across various cancer types, a challenge that is particularly pronounced in oral squamous cell carcinoma. Herein, we developed a sprayable hydrogel loaded with fusion cellular vesicl...

Rethinking sympathetic regulation in cancer: From uniform signaling to context-dependent precision targeting

Accumulating evidence has established the sympathetic nervous system (SNS) as a critical regulator of tumor progression, making adrenergic signaling an attractive therapeutic target in oncology. Consequently, β-adrenergic blockade has been widely investigated as a strategy to inh...

Delayed diagnosis and genetic testing in spinal muscular atrophy: a case series

BACKGROUND: ) gene. Delayed diagnosis of SMA remains a common issue worldwide, particularly in regions with unequal medical resources. CASE PRESENTATION: Patient 1 was a 21-year-old man who had experienced limb weakness and muscle atrophy for 20 years. At the age of 6, he underwe...

Seminiferous Tubules‐Targeted Resveratrol Carbon Dots With Sertoli Cell Biomimetic Vesicles Fusion for Improving Spermatogenesis of Cryptorchidism

ABSTRACT Impaired blood‐testis barrier (BTB) integrity, induced by oxidative stress, is one of the primary factors leading to spermatogenic disorders in cryptorchidism. Therefore, the targeted elimination of testicular oxidative stress and repair of the BTB are promising strategi...

Efficacy and Safety of the First Adalimumab Biosimilar in Chinese Children with Severe Plaque Psoriasis: The PISCES Study, a Multicenter Prospective Study

Adalimumab, a monoclonal antibody targeting tumor necrosis factor-alpha, has been approved for the treatment of severe plaque psoriasis in children aged 4 years and older. Data on its use in the clinical management of pediatric psoriasis in China remains limited. This study is th...

Digital 3D-Printed Surgical Guide for Removal of a Separated Instrument at the Maxillary Sinus Floor and Apical Microsurgery

This case report describes a maxillary first molar with chronic apical periodontitis (CAP) and a separated endodontic instrument migrated to the maxillary sinus floor, which was successfully managed with digital guide-assisted endodontic microsurgery. A 20-year-old female patient...

Efficacy and Safety of Recibokibart, an Interleukin-36 Receptor Antibody, in Generalized Pustular Psoriasis: A Phase 2 Randomized Trial

BACKGROUND: Generalized pustular psoriasis (GPP) is a rare, severe inflammatory skin disease characterized by acute flares. Recibokibart is a humanized IgG1 monoclonal antibody targeting the interleukin-36 (IL-36) receptor. In a phase 1b open-label study, a single intravenous dos...

Risk Scrutiny and Future Opportunities of Robot-Assisted Implant Surgery: A Narrative Review

Introduction and aims Robot-assisted implant surgery (RAIS) signifies a major advancement in computer-guided implant technology. In comparison to traditional hand-guided placement, RAIS enhances the precision and standardization of implant positioning. However, the increased tech...

Neoadjuvant Anbenitamab and HB1801 in ERBB2 -Positive Breast Cancer

IMPORTANCE The combination of neoadjuvant taxanes with trastuzumab and pertuzumab remains the cornerstone treatment strategy in ERBB2 -positive breast cancer. Anbenitamab (a ERBB2 -biparatopic antibody that induces profound receptor clustering) and HB1801 (a solvent-free albumin-...