Second Affiliated Hospital of Zhejiang University

Non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio as a lipid-based marker of hypertension: a large-scale cross-sectional investigation

Abstract Background Dyslipidemia is a known contributor to hypertension, yet the utility of the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) for hypertension assessment remains unclear. We examined whether the NHHR is associated wi...

Integrating nutrition counseling into clinical skills training: a simulation-based interprofessional education program for medical and nursing students

The increasing prevalence of diet-related chronic diseases highlights the urgent need for effective nutrition education in health professions training. This study evaluated a simulation-based interprofessional education (IPE) program designed to enhance nutrition counseling knowl...

Insulin resistance as a potential mediator between central obesity and diabetic kidney disease risk in type 2 diabetes

Abstract Obesity is a key risk factor for diabetic kidney disease (DKD). However, BMI fails to capture body fat distribution. We hypothesized that central obesity, rather than generalized obesity, is associated with DKD risk in patients with type 2 diabetes mellitus (T2DM), and t...

A machine learning-derived dietary pattern for aging

Diet is a modifiable determinant of aging. We develop and validate the Machine-learning YouTHful (MYTH) Diet, a dietary pattern associated with reduced aging-related mortality. Using data from 191,689 participants in the UK Biobank, we conducted a food-wide association analysis a...

3D epigenomic landscape of the human retinal pigment epithelium

The retinal pigment epithelium (RPE) is crucial for visual function, and its dysfunction contributes to retinal diseases such as age-related macular degeneration. Despite the translational potential of iPSC-derived RPE (iPSC-RPE) in cell replacement therapy, the functional visual...

Stability‐Enhanced Therapeutic Artificial Cells Based on a Lipid–Polymer Integrated Architecture

ABSTRACT Current artificial cells often lack robustness in the face of the complex physiological milieu. Additionally, the strategies for mimicking natural cargo exchange mostly rely on biological techniques, which involve integrating native channel proteins or adopting intact na...

Airway administered artificial mitochondria-enriched nanovesicles for efficient and selective mitochondria transfer to intervene in pulmonary fibrosis

Mitochondrial transplantation is a promising therapeutic approach involving the transfer of exogenous mitochondria into diseased cells to restore impaired mitochondrial homeostasis. However, its clinical translation is severely limited by the lack of efficient methods for precise...

Deconstruction of Human Age‐Related Cataract Capsules Defines Aging

ABSTRACT Age‐related cataracts (ARC), a disease associated with aging, is the leading cause of blindness worldwide. To better understand the heterogeneous pathogenesis of ARC and identify potential therapeutic targets, we generate a comprehensive atlas of age‐related cataracts at...

A non-invasive simplified scoring system to predict airway mucus plugs in asthma

Abstract Background Airway mucus plugs are a core pathological feature of severe asthma and are closely associated with airflow limitation and poor prognosis. However, rapid and efficient clinical screening tools for identifying airway mucus plugs in asthma are currently lacking....

Ki-67/p53-associated angiogenic heterogeneity for preoperative WHO grading of meningiomas: a spatial habitat radiomics study

This study aimed to develop and validate a classification model for preoperative prediction of WHO grading of meningioma based on spatial habitat radiomics that can be explained by Ki-67 and p53 biomarkers. A retrospective cohort of 400 patients (261 WHO grade I; 139 grade II/III...

Serum inflammatory cytokines IL-1, IL-6, and TNF-α as biomarkers for predicting the severity of pediatric hand-foot-mouth disease: A retrospective cohort study

This study aimed to explore the association between inflammatory cytokines and the severity of pediatric hand-foot-mouth disease (HFMD) and identify predictive biomarkers. We conducted a retrospective analysis of 240 children, including 120 severe HFMD cases and 120 mild HFMD cas...

Early life sugar rationing and ageing related diseases, biological ageing and mortality

Early-life nutrition may influence lifelong ageing, yet human evidence is scarce. Using Britain’s postwar sugar rationing as a natural experiment, we examine its long-term effects in 64,809 United Kingdom Biobank participants. Exposure to sugar rationing during the first 1,000 da...