Second Affiliated Hospital of Zhejiang University

Mendelian Randomization and Machine Learning for Anatomical Subtyping of Adolescent Sleep Apnea

Introduction and aims Obstructive sleep apnea (OSA) is associated with dentofacial skeletal and soft-tissue anomalies, but whether these anatomical pathways contribute independently, and whether they define clinically distinct subtypes, remain unresolved. We integrated genetic ca...

Aortic valve disease: Novel animal models for advancing our understanding of the underlying mechanisms

Abstract The global public health burden of aortic valve disease (AVD) is growing due to its high mortality rate and lack of suitable pharmaceutical therapies in clinical practice, a challenge that is largely attributable to our poor understanding of its complicated underlying me...

Co-occurrence patterns and related risk factors of type 2 diabetes mellitus and metabolic dysfunction-associated steatotic liver disease

Type 2 diabetes mellitus (T2DM) and metabolic dysfunction-associated steatotic liver disease (MASLD) are interrelated metabolic disorders worldwide. We aimed to characterize global co-occurrence patterns of T2DM and MASLD from a spatial perspective and to identify shared risk fac...

Cross-population genome-wide meta-analysis identifies pancreatic cancer susceptibility loci and etiologic pathways

Abstract Background Pancreatic cancer is a fatal malignancy influenced by genetic, metabolic, and lifestyle factors. We aimed to identify susceptibility loci and clarify associated genes, biological pathways, and potential etiologic factors. Methods We performed a cross-populatio...

Longitudinal Trajectories of the Atherogenic Index of Plasma and Their Associations with Clinical Outcomes After Transcatheter Aortic Valve Replacement

Background/Objectives: The atherogenic index of plasma (AIP) reflects atherogenic dyslipidemia, but the clinical relevance of its longitudinal patterns after transcatheter aortic valve replacement (TAVR) remains unclear. We aimed to characterize AIP trajectories and explore their...

Shared Genetic and Regulatory Architecture of Congenital Heart Disease and Autism Spectrum Disorder Revealed by Cross-Tissue Multi-Omic Integration

Background: Congenital heart disease (CHD) and autism spectrum disorder (ASD) co-occur more frequently than expected, suggesting shared developmental susceptibility. We aimed to identify cross-tissue molecular candidates linking cardiac and neurodevelopmental abnormalities. Metho...

Structural insight into the activation of adenosine A2AR/A2BR by the dual-agonist MRS3997

Abstract A 1 R, A 2A R, A 2B R, and A 3 R adenosine receptors comprise a G protein-coupled receptor (GPCR) subfamily that regulates many bodily processes. Subtype-selective agonists potentially treat inflammatory and ischemic conditions. The dual A 2A R/A 2B R agonist MRS3997 pro...

Associations of psoriasis history with general discrimination‐related experiences in US adults

The data underlying this article are publicly available from IPUMS Health Surveys and the National Center for Health Statistics 2023 National Health Interview Survey.

A canonical role of SMAD4 in safeguarding 3D genome architecture to suppress lung tumorigenesis

Dysregulation of three-dimensional (3D) genome architecture is a hallmark of cancer, yet the mechanisms by which its disruption drives tumorigenesis remain incompletely understood. Here, we demonstrated that SMAD4 regulated 3D genome organization through its canonical transcripti...

Comparative mediation roles of body shape indices in the association between Healthy Eating Index-2015 and phenotypic age acceleration

Aging is a universal physiological process, yet the rate of aging varies significantly among individuals. Phenotypic Age is a biomarker-based measure that reflects biological aging by quantifying the deviation of an individual’s physiological state from their chronological age. D...

Causal association between allergic diseases and short stature: a mendelian randomization study revealing the potential mediating role of inflammatory proteins

OBJECTIVE: Although observational studies have proven a correlation between allergic diseases and short stature (SS), the causal relationship remains unestablished. Furthermore, inflammatory proteins are closely linked with both conditions; their potential mediating role has yet...

From endovascular therapy to perivascular therapy: A new concept and perspective

The cardiovascular system relies on an organ-spanning vascular network not only for transport but also for systemic homeostatic control. Surrounding the vessel wall is a complex perivascular microenvironment, including the vasa vasorum, autonomic and sensory nerves, perivascular...

Rupture of an occult hepatic hemangioma after prolonged cardiopulmonary resuscitation in a patient receiving ECPR for pulmonary embolism: a case report

High-risk pulmonary embolism (PE) may cause refractory cardiac arrest. Venoarterial extracorporeal membrane oxygenation (VA-ECMO) can provide temporary circulatory and oxygenation support during extracorporeal cardiopulmonary resuscitation (ECPR) while definitive reperfusion is p...

Recurrent reversible mutations at gaf1 driving metastable TORC1 inhibitor resistance in fission yeast

ABSTRACT Metastable phenotypic inheritance is often attributed to epigenetic mechanisms, but reversible genetic alterations can produce similar instability. Here, we investigated the basis of unstable resistance to TORC1 inhibitor (rapamycin plus caffeine) in Schizosaccharomyces...

Protocol for designing and evaluating antibody-drug conjugates to promote endocytosis and lysosomal trafficking

Receptor endocytosis and lysosomal delivery are critical for efficient intracellular delivery of antibody-drug conjugates (ADCs), yet many cancer targets exhibit limited internalization. Here, we present a protocol for engineering and evaluating ADCs to induce receptor ubiquitina...

The imaging features of neurovascular compression in hemifacial spasm patients

Neurovascular compression is considered the main cause of primary hemifacial spasm. However, it also occurs on the asymptomatic facial nerves in primary hemifacial spasm patients and in healthy controls. This study aimed to compare neurovascular compression features among the thr...

Delayed Imaging Response After Chemoradiotherapy in a Patient with Unresectable Brainstem Pilocytic Astrocytoma

Adult brainstem gliomas (BSGs) are rare malignant tumors of the central nervous system (CNS) that are difficult to resect completely via surgery, so chemoradiotherapy (CRT) is the primary treatment modality. However, there is substantial interpatient variability in therapeutic re...

Targeted NAD + Metabolic Reprogramming Enables Functional Endometrial Regeneration and Fertility Restoration in Intrauterine Adhesions

ABSTRACT Regeneration of the injured endometrium requires re‐establishment of a permissive microenvironment that supports coordinated epithelial renewal, angiogenesis, and matrix remodeling. However, this regenerative transition remains incomplete in intrauterine adhesions, sugge...

Efficacy of hemodynamic profiling-guided antihypertensive therapy in elderly patients with early morning hypertension: a randomized controlled multicenter clinical study

Abstract Objective To evaluate the efficacy of hemodynamic profiling (HDpro)-guided antihypertensive therapy in elderly patients with uncontrolled morning hypertension. Methods A multicenter randomized controlled trial was conducted in 9 hospitals in Zhejiang Province, enrolling...

Digital echoes of death and dying distress among family members of intensive care unit patients: A qualitative study

Objectives To explore how ICU family members experience and articulate death and dying distress through social media narratives. Methods This study employed a qualitative design informed by the socioecological model and a constructivist epistemological perspective. Data were draw...