Second Affiliated Hospital of Zhejiang University

Deconstruction of Human Age‐Related Cataract Capsules Defines Aging

ABSTRACT Age‐related cataracts (ARC), a disease associated with aging, is the leading cause of blindness worldwide. To better understand the heterogeneous pathogenesis of ARC and identify potential therapeutic targets, we generate a comprehensive atlas of age‐related cataracts at...

A non-invasive simplified scoring system to predict airway mucus plugs in asthma

Abstract Background Airway mucus plugs are a core pathological feature of severe asthma and are closely associated with airflow limitation and poor prognosis. However, rapid and efficient clinical screening tools for identifying airway mucus plugs in asthma are currently lacking....

Ki-67/p53-associated angiogenic heterogeneity for preoperative WHO grading of meningiomas: a spatial habitat radiomics study

This study aimed to develop and validate a classification model for preoperative prediction of WHO grading of meningioma based on spatial habitat radiomics that can be explained by Ki-67 and p53 biomarkers. A retrospective cohort of 400 patients (261 WHO grade I; 139 grade II/III...

Serum inflammatory cytokines IL-1, IL-6, and TNF-α as biomarkers for predicting the severity of pediatric hand-foot-mouth disease: A retrospective cohort study

This study aimed to explore the association between inflammatory cytokines and the severity of pediatric hand-foot-mouth disease (HFMD) and identify predictive biomarkers. We conducted a retrospective analysis of 240 children, including 120 severe HFMD cases and 120 mild HFMD cas...

Early life sugar rationing and ageing related diseases, biological ageing and mortality

Early-life nutrition may influence lifelong ageing, yet human evidence is scarce. Using Britain’s postwar sugar rationing as a natural experiment, we examine its long-term effects in 64,809 United Kingdom Biobank participants. Exposure to sugar rationing during the first 1,000 da...