Second Affiliated Hospital of Zhejiang University

Association of the dietary carbohydrate-to-fiber ratio with prevalent rheumatoid arthritis in NHANES 2009–2018

This study examines the cross-sectional association between the carbohydrate-to-fiber ratio (CFR), an indicator of carbohydrate quality, and prevalent rheumatoid arthritis (RA) in the National Health and Nutrition Examination Survey (NHANES). The exposure was overall CFR, calcula...

Next-generation natural killer cell therapy: bench to bedside and beyond

Natural killer (NK) cells have emerged as central players in cancer immunotherapy, progressing from basic discovery to clinically validated platforms over five decades. This review synthesizes the evolving understanding of NK cell biology, including subset heterogeneity, epigenet...

Gastric serum biomarkers for long-term risk stratification of gastric and extra-gastric cancers: a 26-year cohort study

Gastric serum biomarkers are established for gastric cancer risk assessment, but their utility for extra-gastric malignancies and long-term risk stratification remains unexplored. We prospectively evaluated serum pepsinogens (PGI, PGII), gastrin-17 (G-17) and anti- H. pylori IgG...

A spatiotemporally programmed bioactive scaffold for orbital reconstruction

Orbital implants are widely used for post-enucleation reconstruction, but poor fibrovascularization and infection risk still limit their clinical performance. Herein, a three-dimensional (3D)-printed copper-doped hardystonite (HT, Ca 2 ZnSi 2 O 7 ) scaffold with polar-graded poro...

A Dual‐Delivery System Designed to Overcome EV‐Mediated Ferroptosis Resistance for Efficient Solid Tumor Therapy

ABSTRACT Tumor‐derived extracellular vesicles (EVs) are emerging as critical mediators of metabolic adaptation, yet their role in orchestrating ferroptosis resistance within the tumor microenvironment remains poorly understood. Here, we show that highly malignant osteosarcoma (OS...

Remote‐Controlled Genetic Circuits: Light, Ultrasound, and Magnetic Fields for Programmable Gene Regulation

Remote-controlled genetic circuits use externally applied physical signals to regulate gene expression and cellular functions with spatial and temporal precision. Light, ultrasound, and magnetic fields provide complementary advantages in controllability, tissue accessibility, and...

A Peripheral Sulfonium Moiety Engineering Strategy to Enhance AIEgen-Based Antitumor Photodynamic Therapy

Abstract The therapeutic efficacy of photosensitizers (PSs) strongly depends on their capacity to efficiently generate reactive oxygen species (ROS). Herein, we report a peripheral sulfonium moiety engineering strategy and identify a lead aggregation-induced emission (AIE)-based...

IRP1 affects the long-term survival and function of iTregs by regulating ferroptosis and apoptosis

As an important classification of Tregs, iTregs play a critical role in inducing transplant immune tolerance. Iron metabolism is closely linked to iTreg function, and IRP1 serves as a central regulator of cellular iron homeostasis. However, the relationship between IRP1 and iTreg...

From quantitative features to imaging signs: agentic AI-driven autonomous discovery in glioblastoma

Abstract The development of semantic imaging signs is time-consuming and relies heavily on clinicians’ experiential knowledge, whereas the abundance of quantitative radiomic features often poses challenges in interpretability and clinical translation. We developed an agentic AI p...

Neonatal overfeeding accelerates age-related sarcopenia and metabolic disorders through lifelong gut mucosa and microbiota programming in mice

Early-life nutrition shapes lifelong health, yet the long-term consequences of childhood overnutrition, particularly on musculoskeletal aging, remain unclear. Here, we show that neonatal overfeeding acts as a developmental insult that accelerates age-related sarcopenia in both se...

Macrophage pyroptosis drives luminal senescence and club-cell reprogramming in 5α-reductase inhibitor-treated prostatic hyperplasia

Abstract Benign prostatic hyperplasia (BPH) is a common age-associated disease whose prevalence rises sharply with advancing age. Therapeutic responses to 5α-reductase inhibitors (5-ARIs) in BPH are heterogeneous and may ultimately culminate in the need for surgery; however, the...

A DMD-enabled multimode fiber wavefront shaping interface for spatially addressable optogenetic stimulation

Spatially confined and rapidly addressable light delivery is important for optogenetic stimulation when optical access to the target plane is limited. Digital micromirror device (DMD) has shown its potential for rapid optical control and wavefront shaping through scattering media...

Chlorogenic Acid Derivative B11 Inhibits Glioma Proliferation by Targeting MST4 to Regulate Oxidative Stress

ABSTRACT This study focuses on the mechanism of action of chlorogenic acid derivative B11 on glioma. Although chlorogenic acid exhibits certain anti‐tumor activity, it has limitations such as low bioavailability, broad action targets, and insufficient specificity, which restrict...

Barriers and facilitators to home-based osteoporosis self-management among older lung transplant recipients: a qualitative study

Osteoporosis is common after lung transplantation and is a particular concern in older recipients. It is associated with increased risks of fracture, frailty, disability, and hospital readmission and may compromise functional recovery. After discharge, recipients need to sustain...

Targeting the CD4+ effector memory T cells re-expressing CD45RA suppressor galectin-7: a multi-omics-guided therapeutic strategy for idiopathic pulmonary fibrosis

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive interstitial lung disease with limited therapeutic options. Although single-cell and spatial transcriptomics have revealed cellular heterogeneity within the IPF lung microenvironment, the immune drivers with causal rel...

Cross-cultural adaptation, translation, and psychometric evaluation of the simplified Chinese version of the Team Emergency Assessment Measure (TEAM)

The Team Emergency Assessment Measure (TEAM) questionnaire is a validated tool for evaluating non-technical skills in emergency team performance, such as trauma or resuscitation teams. Despite its translation into multiple languages, a Simplified Chinese version has not been vali...

Efficacy and Safety of Crisugabalin for Inadequately Controlled Diabetic Peripheral Neuropathic Pain: A Randomized, Active‐Controlled, Phase 2 Trial

AIMS: Crisugabalin (HSK16149), a selective γ-aminobutyric acid (GABA) analog, has shown preliminary efficacy in controlling diabetic peripheral neuropathic pain (DPNP), but efficacy in patients with inadequate response to prior pregabalin treatment remains unknown. MATERIALS AND...

Single-cell profiling and genetic regulation of alternative polyadenylation in the human brain

Abstract Alternative polyadenylation (APA) has a central role in regulation of the fate of mRNA and exhibits high variability in the brain and in neurons. However, brain APA regulation has not been mapped at cell type resolution, and the genetic control of APA in brain cell types...

Neddylation E2 enzyme UBE2M inhibits inflammatory lung tumor microenvironment by blocking the cGAS-STING signal upon KrasG12D activation.

activation in the lung.

Prevalence and geographic variation of enteric pathogens among asymptomatic individuals in China: a nationwide, cross-sectional, multiplex molecular survey

The increasing use of multiplex molecular assays has improved the detection of enteric pathogens, but baseline carriage in asymptomatic populations remains poorly characterized, complicating the interpretation of positive test results. We aimed to investigate the prevalence and g...