Second Affiliated Hospital of Zhejiang University

Vitamin D in spine disorders: mechanisms, clinical evidence, and translational gaps—a narrative review

Vitamin D has been increasingly implicated in the pathophysiology of spine disorders, yet its clinical utility remains uncertain. Across a broad spectrum of conditions, including intervertebral disc degeneration, chronic low back pain, lumbar spinal stenosis, spinal deformities,...

Molecular Basis for Activation to Inhibition Switching in Kv7.2 Channel Modulators

ABSTRACT Kv7 voltage‐gated potassium channels play a critical role in controlling electrical properties of excitable tissues. Neuronally‐expressed Kv7 channels are involved in both common and rare neuropsychiatric disorders, ranging from epilepsy to depression and neurodegenerati...

Optimizing Vanadium Single‐Atom Nanozyme via Cluster‐Mediated Charge Orchestration for Modulating Immune Homeostasis in Intracerebral Hemorrhage

ABSTRACT Intracerebral hemorrhage (ICH) triggers excessive reactive oxygen species (ROS) accumulation and persistent neuroinflammation, which synergistically drive progressive neuronal damage and poor neurological functional recovery, severely restricting patient prognosis. Artif...

Associations of C-reactive protein-triglyceride-glucose index and cholesterol-high-density lipoprotein-glucose index with heart disease risk in individuals with cardiovascular-kidney-metabolic syndrome stages 0–3: a cohort study from CHARLS

Abstract Background Although the C-reactive protein-triglyceride-glucose index (CTI) and cholesterol-high-density lipoprotein-glucose index (CHG) have both been implicated in adverse cardiovascular outcomes, their comparative predictive performance for incident heart disease amon...

Vaccinia-related kinase 2 confers pancreatic cancer with gemcitabine resistance through TPI1-driven aerobic glycolysis

Abstract Gemcitabine(GEM)-based chemotherapy is considered the first-line regimen for pancreatic cancer(PC), but the poor responsiveness and chemoresistance greatly limit its application. Metabolic reprogramming, especially aerobic glycolysis, which is regulated by glycolytic enz...

Bidirectional associations between loneliness and physical multimorbidity and the mediating role of social inactivity

Physical multimorbidity and loneliness are increasingly recognised as public health concerns, but the nature of their potential relationships remains unclear. Here we report bidirectional associations between physical multimorbidity and loneliness in middle-aged and older adults...

MDM2/X mediates reduced apoptosis in the plateau zokor: a mechanism of high-altitude adaptation

Murine double minute 2 (MDM2) and murine double minute 4 (MDMX) are critical for the regulation of tumor protein 53 (p53) function and apoptosis. This study compares the Mdm2 / x gene sequences and functional variations of subterranean zokors from the High Plateau and the Loess P...

Safety of TNF-α inhibitors, IL-17 inhibitors, and JAK inhibitors in the treatment of axial spondyloarthritis: a protocol for a multi-method study integrating FAERS data mining, dose–response network meta-analysis, and drug-target Mendelian randomization

Biological and targeted synthetic disease-modifying anti-rheumatic drugs (b/tsDMARDs), including tumor necrosis factor-α inhibitors (TNFi), interleukin-17 inhibitors (IL-17i), and Janus kinase inhibitors (JAKi), are standard treatments for axial spondyloarthritis (axSpA). However...

Mechanism and plasticity of primitive pyroptosis

Pyroptosis is a proinflammatory form of regulated cell death across the tree of life. The gasdermin (GSDM) protein family functions as an evolutionarily conserved executioner of pyroptotic cell death by forming membrane pores. As the canonical activation mechanism, proteolytic cl...

Acute ST-Segment Elevation Myocardial Infarction Following Multimodality Cancer Therapy in a HER2-Positive Breast Cancer Patient: A Case Report

Cardiovascular toxicity associated with anti-tumor therapies is garnering increased attention. Anti-tumor therapies may elevate the risk of acute coronary syndrome, particularly in patients with underlying subclinical atherosclerosis. In this context, a 58-year-old female patient...

Mefatinib versus gefitinib as a first-line treatment for EGFR-mutated non-small cell lung cancer: a randomized, double-blind, multicenter phase III study

Mefatinib, a novel second-generation epidermal growth factor (EGFR) tyrosine kinase inhibitor that has shown promising antitumor activity in targeting non-small cell lung cancer (NSCLC) with common and uncommon EGFR- activating mutations. In this phase III, randomized, double-bli...

Codon optimization depletes stop codons in alternative reading frames of protein-coding nucleic acid therapeutics

Out-of-frame translation events, arising from ribosomal frameshifting or noncanonical initiation, are an unavoidable feature of translation. Their consequences depend on the distribution of stop codons in alternative reading frames, which determines the permissiveness of those fr...

A dual-mode radiofrequency ablation catheter with advanced thermal sensing for saphenous and perforator vein insufficiency: a preclinical study on goats

为克服现有进口器械热损伤风险高、 与国内临床常用的 6 Fr 鞘管不兼容等局限性, 我们研发了一款名为 Saphenus 的新型国产射频消融 (RFA) 导管系统。 其核心创新点包括: 6 Fr 外径设计 (适配国内常用鞘管), 独特的双模工作长度设计 (8 mm 用于穿通静脉, 80 mm 用于大隐静脉), 以及优化的温度传感机制以...

hESC-MSC-EVs attenuate post-cardiac arrest brain injury by inhibiting cGAS/STING-mediated neuronal pyroptosis

Cardiac arrest-induced brain injury significantly affects patient prognosis, yet effective therapeutic strategies remain lacking in clinical practice. In recent years, mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) have garnered considerable attention for their no...

Randomized phase 2 trial of a PARP inhibitor TSL-1502 in germline BRCA-mutated, HER2-negative locally advanced/metastatic breast cancer

Glucuronide prodrug strategies may enhance target specificity and reduce the toxicity of PARP inhibitors, but no clinical evaluation has been performed. We evaluated TSL-1502, a novel glucuronide prodrug of a PARP inhibitor, in a randomized, open-label, phase 2 study at 28 sites...

A multimodal Vision-Mamba model based on non-contrast CT hematoma and shell features predicts early hematoma expansion in hypertensive intracerebral hemorrhage: a multicenter study

To develop and evaluate a multimodal Vision-Mamba deep learning (DL) model integrating clinical data, noncontrast computed tomography (NCCT) hematoma features, and shell features to predict early hematoma expansion (EHE) in hypertensive intracerebral hemorrhage (HICH). In this mu...

Non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio as a lipid-based marker of hypertension: a large-scale cross-sectional investigation

Abstract Background Dyslipidemia is a known contributor to hypertension, yet the utility of the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) for hypertension assessment remains unclear. We examined whether the NHHR is associated wi...

Risk factors for Gram-negative bacterial bloodstream infections: a systematic review and meta-analysis with subgroup analyses for carbapenem-resistant organisms and Acinetobacter baumannii

Abstract Background Gram-negative bacterial (GNB) bloodstream infections (BSIs), particularly those caused by carbapenem-resistant GNB (CR-GNB) and Acinetobacter baumannii (AB), are associated with substantial morbidity and mortality. This study aimed to provide, to our knowledge...

Insulin resistance as a potential mediator between central obesity and diabetic kidney disease risk in type 2 diabetes

Abstract Obesity is a key risk factor for diabetic kidney disease (DKD). However, BMI fails to capture body fat distribution. We hypothesized that central obesity, rather than generalized obesity, is associated with DKD risk in patients with type 2 diabetes mellitus (T2DM), and t...

A machine learning-derived dietary pattern for aging

Diet is a modifiable determinant of aging. We develop and validate the Machine-learning YouTHful (MYTH) Diet, a dietary pattern associated with reduced aging-related mortality. Using data from 191,689 participants in the UK Biobank, we conducted a food-wide association analysis a...