Renmin Hospital of Wuhan University

MINK1 inhibition suppresses triple-negative breast cancer by abrogating ALDOA S39 phosphorylation and reprogramming glucose metabolism

Triple negative breast cancer (TNBC) represents the most malignant subtype of breast cancer, with heightened invasiveness, frequent recurrence and poor prognosis. Deciphering the molecular mechanisms underlying TNBC pathogenesis and drug resistance is critical for developing prec...

Environmental pollutant UV-328 exacerbates chronic colitis and is associated with altered cholesterol metabolism

Environmental exposure is increasingly recognized as an important contributor to the onset and progression of inflammatory bowel disease (IBD). Although the benzotriazole ultraviolet stabilizer UV-328 is widely present in environmental matrixes and biological samples, and exhibit...

The evolving role of TP53 mutation in hepatocellular carcinoma (HCC)

Hepatocellular carcinoma (HCC) is one of the most common cancer types globally, which is characteristically aggressive, with a poor prognosis and a high mortality rate. The pathways leading to the development and progression of this fatal disease have been studied at the macro an...