Renmin Hospital of Wuhan University

CST1 stabilizes GPX4 to suppress ferroptosis and promote bladder cancer progression

Cystatin SN (CST1), a cysteine protease inhibitor, participates in various cancers, yet its function and mechanism in bladder cancer (BCa) are unclear. Public databases, BCa cells and clinical samples were used to analyze CST1 expression profiles. Functional experiments detected...

Neferine Exerts a Protective Effect on Rat Osteoarthritis by Upregulating Autophagy

Osteoarthritis (OA) is a prevalent chronic joints disorder, characterized by progressive degeneration of articular cartilage accompanied by joint inflammation. The development of a safe and effective pharmacological therapy is highly anticipated. This research was designed to com...

Single-Cell Transcriptomic Analysis Reveals Copper Metabolism Heterogeneity and Phenotypic Remodeling in Vaginal Anterior Wall Stromal Cells in Pelvic Organ Prolapse

Pelvic organ prolapse (POP) is a common disease characterized by disordered extracellular matrix (ECM) remodeling of pelvic support tissues. Copper dysregulation drives fibrosis in multiple diseases, whereas its function in POP remains unclear. We analyzed single-cell transcripto...

Interactions between lactobacillus and yeast: A recent update

Abstract Lactobacillus and yeast are microorganisms widely distributed in nature. Their interactions significantly impact fermentation processes, human health, and medical care. However, there is a lack of a systematic summary of the characteristics of these interactions, and the...

Temporal Single-Nucleus Transcriptomics Defines PPARα/CPT1A-Associated Metabolic Reprogramming During Proximal Tubular Injury and Repair

Background: Metabolic reprogramming and mitochondrial dysfunction are central features of acute kidney injury (AKI), yet their temporal relationship with proximal tubular cell-state remodeling remains incompletely understood. This study aimed to characterize early metabolic alter...

Maresin 2 Attenuates Hypertensive Vascular Remodeling via Inhibiting Macrophage Infiltration and Pro‐fibrotic Polarization

ABSTRACT Immune‐inflammatory responses are pivotal regulators of hypertensive vascular remodeling. Specialized pro‐resolving mediators (SPMs), including Maresin 2 (MaR2), are endogenous anti‐inflammatory molecules. However, the specific role of MaR2 in regulating hypertension and...

Artificial intelligence-based assessment of gastric mucosal exposure and its association with lesion detection: a multicenter study

Completely and clearly visualizing the mucosa during esophagogastroduodenoscopy (EGD) improves high-risk lesion detection. Here we propose a new EGD quality control indicator and present the optimal gastric mucosal exposure area (OGMEA) system to automatically assess mucosal expo...

C/EBPβ/AEP pathway mediates synaptic impairments and depression-like phenotypes induced by chronic stress

Depression is a common psychiatric disorder characterized by episodes of low mood. Disruptions in synaptic homeostasis contribute to the onset of depression. However, the molecular mechanisms underlying synaptic impairments in depression remain elusive. Here we show that chronic...

Therapeutic targeting of the SLC39A13-AS1/TCF20/RUNX1 axis inhibits glutamine metabolism and ovarian cancer progression

“Glutamine addiction” is among the key features of tumor metabolic reprogramming and is an important target for tumor therapy. Unfortunately, the mechanisms underlying the abnormal expression of genes related to glutamine metabolism in ovarian cancer (OC) remain unclear. Here, we...

Cardiac fibroblast-derived GNL3 aggravates acute doxorubicin-induced cardiac injury via FasL-linked fibroblast–cardiomyocyte crosstalk

Doxorubicin (DOX)-induced cardiac injury remains a major clinical challenge in oncology, with limited preventive strategies beyond dexrazoxane. Although cardiomyocyte-centered mechanisms dominate current understanding, the contribution of cardiac fibroblasts (CFs) remains incompl...

Sigma-1 receptor protects against renal ischemia-reperfusion injury by enhancing mitophagy via Rac1 regulation

Renal ischemia-reperfusion injury (IRI) is a leading cause of acute kidney injury, associated with mitochondrial dysfunction, excessive reactive oxygen species (ROS) production, and tubular cell apoptosis. The Sigma-1 receptor (Sigma1R), an intracellular chaperone, plays a crucia...

Associations of Anatomical Location and Reader Experience With the Diagnostic Performance of Multiparametric MRI ‐Derived VI ‐ RADS for Muscle Invasive Bladder Cancer: A Multicenter Multireader Study

ABSTRACT Background The associations of tumor location and reader experience with Vesical Imaging‐Reporting and Data System (VI‐RADS) performance remain unclear. Purpose To evaluate the associations of tumor location and reader experience with VI‐RADS performance in detecting mus...

MicroRNA-2110 acts as a tumor suppressor in gastric cancer via direct targeting of IGF1R

Abstract Background MicroRNA-2110 has been implicated in cancer, but its expression and function in gastric cancer (GC) remain understudied. This study aims to explore the role of miR-2110 in GC and its regulation of IGF1R. Methods RT-qPCR was used to measure miR-2110, IGF1R expr...

Gentiopicroside Regulates EGFR and Induces Its Lysosomal Degradation to Attenuate Heart Failure

ABSTRACT Cardiac hypertrophy is a major pathological response to cardiovascular stress and a critical contributor to heart failure (HF). Gentiopicroside (GPS), a naturally occurring iridoid glycoside derived from Gentiana scabra, exhibits anti‐inflammatory, antioxidant, and anti‐...

Nanomedicine‐driven innovations in postoperative cancer immunotherapy: Remodeling tumor microenvironment and precision delivery strategies

Abstract Postoperative recurrence remains a critical challenge in cancer management, necessitating innovative strategies to reshape the tumor microenvironment (TME) and enhance immune surveillance. This review highlights nanomedicine‐driven breakthroughs in postoperative immunoth...

Early recognition and systemic management of retinal vasculitis in a 15-year-old male

Retinal vasculitis is an inflammatory disorder of the retinal vasculature with diverse etiologies. This case is reported for its relatively uncommon age and distinctive signs, emphasizing the identification of subclinical involvement and the efficacy of early systemic interventio...

REDD1 Silencing Aggravates Aortic Dissection and Promotes VSMC Apoptosis with Autophagy-Related Changes

Background: Aortic dissection (AD) is a life-threatening vascular disease with high mortality, yet its molecular pathogenesis remains incompletely understood. This study investigated the role of regulated in development and DNA damage responses 1 (REDD1) in vascular smooth muscle...

Longitudinal Study on Post‐Traumatic Stress Disorder, Anxiety, and Depression Among Medical Staff in China

ABSTRACT Background Evidence of the longitudinal relationship between anxiety, depression, and post‐traumatic stress disorder (PTSD) is not uniform. This study aimed to explore the dynamic changes, independent factors, and bidirectional predictive relationships of anxiety, depres...

A Novel Mouse Model for Venous High-Load Remodeling Induced by Unilateral Jugular Vein Transection

Chronic venous disease (CVD) is a prevalent peripheral vascular disorder characterized by vascular remodeling driven by hemodynamic overload, yet available animal models are limited by high surgical difficulty and unstable induction efficiency. Here, we developed a novel mouse ve...

Adjunctive n-3 PUFA supplementation improves niacin skin flush response and shows biomarker-stratified signals in schizophrenia

BACKGROUND: Findings regarding the efficacy of n-3 polyunsaturated fatty acid (PUFA) supplementation as an adjunct treatment for schizophrenia (SZ) have been inconsistent. This study investigated whether n-3 PUFA supplementation was associated with changes in niacin skin flush re...