Renmin Hospital of Wuhan University

Efficacy and Safety of Recibokibart, an Interleukin-36 Receptor Antibody, in Generalized Pustular Psoriasis: A Phase 2 Randomized Trial

BACKGROUND: Generalized pustular psoriasis (GPP) is a rare, severe inflammatory skin disease characterized by acute flares. Recibokibart is a humanized IgG1 monoclonal antibody targeting the interleukin-36 (IL-36) receptor. In a phase 1b open-label study, a single intravenous dos...

Development and benchmark validation of PubChat for PubMed-grounded multilingual biomedical literature retrieval

The rapid growth of biomedical literature has rendered traditional systematic reviews unsustainable. Although large language models (LLMs) offer automation potential, citation fabrication and unreliable evidence discrimination remain critical barriers. Here, using PubChat as a Pu...

Experiences of social participation and inclusion among primary caregivers of children with cerebral palsy in China: a qualitative descriptive study

Primary caregivers of children with cerebral palsy (CP) may experience challenges affecting their social participation and inclusion. However, these experiences remain insufficiently understood in the Chinese context. Understanding these experiences is important for family-centre...

A Novel Sparse Cellular Labeling System with Tunable Gradients and Long‐Term Stability

ABSTRACT The dense packing of cells within tissues poses challenges for studying cellular properties. Sparse labeling, genetically targeting a small subset of densely distributed cells, provides a powerful approach to investigate cellular morphology, connectivity, dynamics, and f...

Extracellular matrix remodeling upregulates hippocampal neurogenic niche stiffness and impairs neurogenesis in Alzheimer's disease

Abstract INTRODUCTION Preserving adult hippocampal neurogenesis alleviates cognitive deficits in Alzheimer's disease (AD), yet how biophysical alterations in such as stiffness in the neurogenic niche regulate neurogenesis remains unclear. METHODS Stiffness in the hippocampal dent...

Serum miR-378d is associated with liver stiffness and fibrosis risk in patients with metabolic dysfunction-associated steatotic liver disease

Tissue biopsy is the gold standard for diagnosing metabolic dysfunction-associated steatohepatitis (MASH), but it is invasive and time-consuming to analyze. This paper aimed to explore the association between serum miR-378d and liver stiffness and fibrosis risk in patients with m...

Identification of Ferro‐Aging‐Related Biomarkers for Ulcerative Colitis Through Integrated Machine Learning, Single‐Cell Analysis, and Spatial Transcriptomics

Ulcerative colitis (UC) is characterized by chronic mucosal inflammation, epithelial injury, oxidative stress, and marked molecular heterogeneity. Ferro-aging has recently been proposed as an ACSL4-associated, iron-dependent aging-related state in primates, but whether its associ...

Targeted microglial ROS-scavenging alleviates neuroinflammation and cognitive deficits via restoration of the 2-AG/CB2R signaling axis in schizophrenia

Cognitive impairment in schizophrenia is inadequately treated. The molecular link between oxidative stress and neuroinflammation in its pathophysiology remains unclear. We measured CB2R in circulating microglia‑derived exosomes from schizophrenia patients and healthy controls. In...

Trilobatin, a Natural Dihydrochalcone, Stabilizes Nrf2 to Protect the Heart from Angiotensin II–Induced Oxidative and Hypertrophic Stress

Aims: Oxidative stress–driven cardiac remodeling is a key pathological feature of heart failure and hypertensive heart disease, yet effective antioxidant therapies remain limited. This study aimed to determine whether the natural dihydrochalcone trilobatin (Tri) protects against...

A phase III clinical trial of PXT3003 in Chinese patients with Charcot-Marie-Tooth disease type 1A

Charcot-Marie-Tooth disease type 1A (CMT1A) is the most common inherited peripheral neuropathy and currently lacks disease-modifying therapy. PXT3003, a low-dose oral combination targeting PMP22 overexpression, has shown efficacy in two trials, while one recent confirmatory trial...

SRPK3 exacerbates cardiac ischemia/reperfusion injury by regulating KLF3-mTOR/P70 S6K-mediated autophagy

Myocardial ischemia-reperfusion (I/R) injury remains a leading cause of cardiac dysfunction and mortality worldwide. Serine/arginine-Rich Protein Kinase 3 (SRPK3) is highly expressed in cardiac muscle, yet its specific pathological role in I/R injury has not been fully characteri...

Adolescent environmental enrichment prevents early-life stress-induced schizophrenia-like phenotypes via restoration of CREB-BDNF-TrkB signaling

Early-life stress (ELS) is a major environmental risk factor for schizophrenia, yet effective preventive strategies targeting its neurodevelopmental consequences remain limited. Here, we show that adolescent environmental enrichment (EE) prevents the emergence of schizophrenia-li...

Patient-specific static and dynamic 3D-printed models for planning endovascular repair of complex aortic disease with physician-modified stent grafts

Abstract Objective To develop a patient-specific static and dynamic 3D-printing workflow for preoperative planning of endovascular repair in complex aortic disease with physician-modified stent grafts, to assess the respective roles of rigid anatomical and dynamic models, and to...

CACA guidelines for the management of adult cancer pain

Abstract Cancer pain, one of the most prevalent and distressing symptoms in cancer patients, is closely associated with cancer diagnosis, therapeutic interventions, quality of life, and survival outcomes. Effective cancer pain management requires multidisciplinary collaborative a...

Decreased cerebrospinal fluid NDRG2 is associated with non-Alzheimer's disease derived mild cognitive impairment

Background Mild cognitive impairment (MCI) lacks clear clinical biomarkers. N-Myc downstream-regulated gene 2 (NDRG2) is predominantly localized in astrocytes and is implicated in cognitive function. Objective This study aims to explore whether cerebrospinal fluid (CSF) NDRG2 cou...

Individualized hybrid electroconvulsive therapy (i-HECT) shows rapid anti-depressant effect in young patients with depression

Abstract Background For young patients with depression, electroconvulsive therapy (ECT) is highly effective but causes acute cognitive side effects. We designed a new individualized hybrid electroconvulsive therapy (i-HECT) combines ECT with low-charge electrotherapy (LCE) and in...

Hepatocyte OTUD1 promotes hepatic stellate cell activation and liver fibrosis by stabilizing HSP90β

Crosstalk between parenchymal and nonparenchymal cells of the liver mediates the activation of hepatic stellate cells (HSCs). Activated HSCs transform into myofibroblasts and produce the extracellular matrix (ECM), and massive ECM accumulation can affect liver function and eventu...

Innovative abdominoperineal surgery for fertility-preserving cervicovaginal reconstruction in five patients with the rare condition of congenital cervical malformation coexisting with vaginal atresia

Congenital cervical malformation coexisting with vaginal atresia is a rare but challenging anomaly that obstructs menstrual outflow and threatens future fertility. This study aimed to describe a fertility-preserving laparoscopic abdominoperineal cervicovaginal reconstruction tech...

Associations of outdoor artificial light at night with type 2 diabetes and metabolic syndrome among Chinese adults

This study investigated the associations between outdoor artificial light at night (ALAN) and type 2 diabetes (T2DM) and metabolic syndrome (MetS) and aimed to characterize the dose-response relationships and potential exposure thresholds. This cross-sectional study included 57,8...

The COACH theory formalizes clinical reasoning in the development and validation of medical artificial intelligence systems

The development and deployment of medical artificial intelligence (AI) systems are limited by two persistent gaps: clinician knowledge is often introduced late in development as labels or annotations, and deployed systems often provide outputs that are difficult to reconcile with...