Qingdao University

Comprehensive genomic characterization of extraintestinal pathogenic Escherichia coli isolated from neonates: multiple center insights into virulence, resistance, and transmission dynamics

Neonatal extraintestinal pathogenic Escherichia coli (ExPEC), which can cause severe long-term sequelae by systemic infections, is gradually becoming the primary pathogen threatening neonatal health. The lack of large-scale genomic epidemiological investigation hinders further un...

Inhibitors ofthe Influenza Virus Polymerase Basic2 (PB2): Recent Advances and Future Perspectives

Abstract Influenza, an acute respiratory infectious disease caused by influenza viruses, poses a serious public health threat with high infectivity and virulence. Existing antivirals suffer from numerous limitations, such as the frequent emergence of drug resistance and inconveni...

Risk factors for incident chronic kidney disease following unilateral nephrectomy: a systematic review and meta-analysis

Nephrectomy is standard for kidney tumors and living kidney donation, but postoperative chronic kidney disease (CKD) is a critical determinant of long-term outcomes. Risk factors for incident CKD after unilateral nephrectomy remain incompletely synthesized. PubMed, Embase, Web of...

Abdominal fat thickness predicts the risk of pregnancy-associated hypertension: A prospective cohort study.

BACKGROUND AND OBJECTIVES: Pregnancy-associated hypertension (PAH) is a prevalent complication during pregnancy. Maternal obesity is a known risk factor for PAH. As nutrition is a key modifiable driver of obesity and metabolic health, this study aimed to evaluate whether early-pr...

A mitochondria-related 9-gene induced sputum signature for severe asthma: an integrative transcriptomic analysis with external validation

OBJECTIVE: Severe asthma is biologically heterogeneous, and airway-derived biomarkers for disease stratification remain limited. We aimed to identify a mitochondria-related induced sputum transcriptomic signature associated with severe asthma. METHODS: Two public induced sputum m...

Post-injury high-sensitivity C-reactive protein to lymphocyte ratio and nonunion risk in adult extremity fractures: evidence from a multicenter retrospective cohort

Early immuno-inflammatory response serves a critical role in the process of fracture healing, and both excessive and insufficient activation after injury may predict adverse outcomes. This study aimed to investigate the association between post-injury high-sensitivity C-reactive...