Qingdao University

Associations of cumulative exposure and change pattern of the C-reactive protein-triglyceride-glucose index with stroke risk in a population with cardiovascular-kidney-metabolic syndrome stages 0–3: a longitudinal analysis based on CHARLS

The C-reactive protein–triglyceride-glucose index (CTI) has shown potential in cardiometabolic risk assessment. However, evidence regarding cumulative CTI (cuCTI) exposure, longitudinal CTI change pattern, and incident stroke in individuals with cardiovascular-kidney-metabolic (C...

Prediction of prognosis and treatment effect of cervical cancer by immunogenic cell death-related genes

Background Immunogenic cell death (ICD) is a potential mechanism that mediates adaptive immune responses during anticancer therapy. However, expression patterns and clinical implications of ICD related genes in cervical squamous cell carcinoma and endocervical adenocarcinoma (CES...

Natural pigment-based semiconductor isomers as interfacial layers in organic photovoltaic devices

Purpose This study aims to develop bio-based interfacial materials for organic photovoltaic applications by engineering carotenoid-derived molecular frameworks with favorable energy level alignment and enhanced light-harvesting capability. Design/methodology/approach Three diphen...

Design of a load-responsive mechanical pressure limiter for overload protection in hydraulic actuators

To improve the overload protection performance of hydraulic actuators under dynamic load variations, a load-responsive mechanical pressure-limiting device is proposed with a wheel loader as the application background. The device integrates a pressure-sensitive element, a pressure...

Intramolecularly Self-Activated Degradable Aromatic Polyesters Inspired by RNA Autohydrolysis

Abstract The long-term persistence of conventional aromatic polyesters remains a major challenge for polymer sustainability. Inspired by RNA autohydrolysis, we developed two self-activated degradable aromatic polyesters, poly(2,2-ethyl carboxylate-1,3-propanediol terephthalate) (...

Palladium-Catalyzed Enantioselective Dearomative Domino Heck/Stille Reaction of Indoles

Abstract Palladium-catalyzed enantioselective dearomative difunctionalization of N-substituted indoles was developed via dearomative carbonpalladation and subsequent capture of benzyl-Pd species by organostannane reagents (domino Heck/Stille reaction). A wide range of 2,3-disubst...

Supramolecular Polymerization of Triphenylamine[3]arenes for Switchable and Stimuli‐Responsive Chiroptical Properties

ABSTRACT The design of advanced photonic materials with integrated stimuli‐responsive properties remains coveted yet challenging. Herein, we demonstrate that chiral supramolecular assembly of triphenylamine[3]arenes (TPA[3]s) offers an efficient and modular solution to address th...

Metabolic Dysregulation and Metabolite-Targeted Interventions in Autism Spectrum Disorder: Mechanisms and Translational Perspectives

Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder marked by impaired social communication and restricted repetitive behaviors. Metabolic dysregulation is increasingly recognized as a key intermediate mechanism linking genetic and environmental factors...

Targeting the CD4+ effector memory T cells re-expressing CD45RA suppressor galectin-7: a multi-omics-guided therapeutic strategy for idiopathic pulmonary fibrosis

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive interstitial lung disease with limited therapeutic options. Although single-cell and spatial transcriptomics have revealed cellular heterogeneity within the IPF lung microenvironment, the immune drivers with causal rel...

Electrochemiluminescence shunt via bi-based co-reaction accelerator for the identification of pentanol isomers

Pentanol represents an attractive clean-burning biofuel, yet fuel commonly contain multiple structurally similar pentanol isomers that perturb the flash-point and impair combustion performance, necessitating the differentiated identification of pentanol isomers. Herein, we propos...

Global epidemiological and genetic burden of rare neurological diseases in children

We assessed the global burden of rare childhood neurological diseases from 1990 to 2021 and projected trends to 2050 using Global Burden of Disease data, alongside an analysis of the genetic burden from ClinVar. Four neurological conditions were classified as rare childhood neuro...

A hybrid CNN-transformer network with global-local context feature aggregation for lung medical image segmentation

Accurate lung segmentation is a key prerequisite for computer-aided diagnosis of pulmonary diseases on chest CT and X-ray images. Lung segmentation, however, remains highly challenging due to the complex anatomy of the lung, ambiguous lesion boundaries, low tissue contrast, and t...

Air/CO 2 Stepwise Induction of Fe Nanocluster Enrichment in FeMgAlOx Solid‐Solution Catalysts for Single‐Walled Carbon Nanotube Growth

ABSTRACT Solid‐solution catalysts hold great promise as low‐cost catalysts for the growth of small‐diameter single‐walled carbon nanotubes (SWCNTs); however, their catalytic performance is limited by low metal‐site utilization and unfavorable interfacial structures in conventiona...

Effect of wave-induced motion on the energy harvesting performance of a floating solar-powered AUV

This paper proposes a novel concept of a solar-powered autonomous underwater vehicle (AUV) featuring a foldable solar wing panel. The design enables energy harvesting during surface floating operations. We investigate the time-varying energy harvesting characteristics due to the...

Quercetin Ameliorates Cognitive Impairment in Obese Mice by Activating the PI3K/AKT/GSK3β Signaling Pathway via the Microbiota–Gut–Brain Axis

Abstract Obesity and its associated insulin resistance are important risk factors for cognitive impairment. In this study, a 10-week C57BL/6 mouse model was established to investigate the effects of dietary quercetin supplementation at 0.05% (w/w) on HFFD-induced obesity-related...

APOF regulates the malignancy and inflammatory response of hepatocellular carcinoma cells through PPAR signaling pathway

Hepatocellular carcinoma (HCC) is a malignant tumor with high incidence. It is often diagnosed at an advanced stage, with intrahepatic or extrahepatic metastasis, and cannot be cured by radical surgery. In human HCC cell lines, Apolipoprotein F (APOF) gene promoter activity was s...

Low miR-106a-5p is associated with burn-related DVT and may regulate endothelial injury via TXNIP

Among burn patients, deep vein thrombosis (DVT) frequently arises as a critical complication. This article aims to explore the mechanism of miR-106a-5p in DVT in burn patients, providing a basis for identifying early diagnostic markers and developing therapeutic targets. This stu...

Transition from a fund-based to a lifecycle-oriented EPR system: the evolution of extended producer responsibility for electrical and electronic equipment in China

Abstract The Extended Producer Responsibility (EPR) system for electrical and electronic equipment in China has evolved from a “fund-based” to a “special fund” model. To transcend conventional end-of-pipe governance, we propose an “EPR 3.0” framework that extends environmental re...

Combined femoral nerve block and posterior knee pain-point infiltration for early passive knee training after total knee arthroplasty: a two-center sham-controlled proof-of-concept randomized trial

Abstract Background We assessed whether a combined regional analgesic regimen administered immediately before passive knee training on postoperative day 3 was associated with active knee range of motion (ROM) 90 days after the intervention. Methods In this two-center, parallel-gr...

Carbon nanotubes serving as fixed and flowable beds for enhanced methane storage in hydrates

Achieving the rapid formation of methane hydrates together with high density is critical to utilize this hydrate-based energy storage technology. Herein, CNTs were adopted as the media for methane hydrate formation, which were designed as fixed or flowable beds by regulating the...