Qingdao University

On the Bottom‐Up Construction of Many‐Electron Relativistic QED Hamiltonian

ABSTRACT It was shown more than a decade ago [J. Chem. Phys. 139, 014108 (2013)] that a many‐electron relativistic quantum electrodynamics (QED) Hamiltonian for high‐precision electronic structure calculations can be constructed in a bottom‐up fashion, by virtue of charge‐conjuga...

A Multifunctional Finishing Strategy for Lyocell Fabric Integrating Durable Flame Retardancy and Enhanced Dyeing Performance via One‐Bath Process

ABSTRACT In our previous work, a fully bio‐based flame retardant (PALA) was synthesized from phytic acid and L‐arginine and applied to Lyocell fabric, significantly enhancing its flame retardancy and washing durability. This study further develops a one‐bath synergistic process i...

Analysis of birefringence modulation performance in RM-embedded CO-polymer waveguides

Uncontrolled birefringence causes measurement errors and signal distortion in high-precision optical systems, yet existing modulation methods suffer from complex fabrication or poor stability. Polymer waveguides serve as low-cost, flexible alternatives to traditional lithium niob...

Mefatinib versus gefitinib as a first-line treatment for EGFR-mutated non-small cell lung cancer: a randomized, double-blind, multicenter phase III study

Mefatinib, a novel second-generation epidermal growth factor (EGFR) tyrosine kinase inhibitor that has shown promising antitumor activity in targeting non-small cell lung cancer (NSCLC) with common and uncommon EGFR- activating mutations. In this phase III, randomized, double-bli...

Holistic Inside‐Out Reconfiguration of Ni‐Rich Cathodes via a Thermally Self‐Driven Strategy for Exceptional Chemomechanical Stability

ABSTRACT Ni‐rich layered oxides (LiNi x Co y Mn 1− x − y O 2 , x ≥ 0.8) are indispensable for high‐energy‐density lithium‐ion batteries, yet they suffer from severe chemomechanical degradation driven by the synergy of internal microcracking and interfacial parasitic side reaction...

Rapid Non-Destructive Mango Variety Identification Using Multi-Scale Global Context Network with NIR Spectroscopy

Accurate identification of mango varieties holds substantial significance for the elevation of product added value and the facilitation of market differentiation through quality-based pricing. Near-infrared (NIR) spectral analysis offers a rapid, non-destructive solution for mang...

Estimating individualized gonadotropin starting doses in women with PCOS: a target-driven machine learning model for GnRH-antagonist stimulation

Abstract Background Women with polycystic ovary syndrome (PCOS) are prone to excessive ovarian response and ovarian hyperstimulation syndrome (OHSS) during controlled ovarian stimulation, whereas overly conservative gonadotropin (Gn) dosing reduces oocyte yield and efficiency. Th...

Microfluidic engineering of CeO2/Peptide nanosheet-integrated bioactive hydrogel microspheres for multi-enzymatic biomimetic catalytic therapy of osteoarthritis

Osteoarthritis (OA) is a degenerative joint disease characterized by chronic inflammation and oxidative stress-induced cartilage degeneration, yet effective disease-modifying therapies remain limited. Herein, we report a CeO 2 /peptide nanosheet (CeP)-integrated hydrogel microsph...

Activating Cannabinoid receptor 2 alleviates iron overload-induced liver damage via dual modulation of STAT3/hepcidin and Nrf2/FPN1 pathways

Iron overload-related liver injury is a major clinical problem in hereditary hemochromatosis, transfusional siderosis, and chronic liver diseases, yet current treatments such as iron chelation therapy and phlebotomy are limited by safety and efficacy issues. Cannabinoid receptor...

Landscape Ecological Risk Evolution and Its Nonlinear Driving Mechanisms in a Topographically Constrained River-Valley Basin: A Case Study of the Taiyuan Section of the Fen River Basin

In regions where severe topographic constraints coincide with intensive human activity, the mechanisms underlying landscape ecological risk (LER) and its spatial differentiation remain poorly understood. In particular, the nonlinear responses and threshold effects arising from th...

Macrophage-derived IL-1β drives endothelial-mesenchymal transition in diabetes mellitus erectile dysfunction

Diabetes mellitus erectile dysfunction (DMED) is frequently accompanied by corpus cavernosum (CC) fibrosis and endothelial dysfunction; however, the cellular drivers and molecular mechanisms underlying these pathological changes remain incompletely understood. Endothelial-to-mese...

Magnetic Insights Into Heterogeneous and Nonequilibrium Electrochemical Reactions

ABSTRACT Electrochemical energy systems are governed by interfacial reactions that are spatially heterogeneous and far from equilibrium, causing deviations from ideal behavior and unexpected phenomena. Despite significant advances, conventional characterization techniques remain...

Neural regulation in lung cancer: from mechanisms to new therapeutic perspectives

Lung cancer remains a leading cause of cancer-related deaths worldwide. Despite advances in targeted therapy and immunotherapy, treatment outcomes are often constrained by tumor heterogeneity and the complex tumor microenvironment. Recent studies highlight the critical role of th...

The Matricellular Protein CCN1 Induces Corneal Stromal Cells Senescence and Inflammation to Trigger Extracellular Matrix Remodeling in Keratoconus

Purpose: Keratoconus (KC) is a multifactorial corneal degenerative disorder characterized by reduced extracellular matrix (ECM) and cellular content. This study investigates the role and mechanism of cellular communication network factor 1 (CCN1) in KC progression. Methods: The e...

Comprehensive genomic characterization of extraintestinal pathogenic Escherichia coli isolated from neonates: multiple center insights into virulence, resistance, and transmission dynamics

Neonatal extraintestinal pathogenic Escherichia coli (ExPEC), which can cause severe long-term sequelae by systemic infections, is gradually becoming the primary pathogen threatening neonatal health. The lack of large-scale genomic epidemiological investigation hinders further un...

Inhibitors ofthe Influenza Virus Polymerase Basic2 (PB2): Recent Advances and Future Perspectives

Abstract Influenza, an acute respiratory infectious disease caused by influenza viruses, poses a serious public health threat with high infectivity and virulence. Existing antivirals suffer from numerous limitations, such as the frequent emergence of drug resistance and inconveni...

Risk factors for incident chronic kidney disease following unilateral nephrectomy: a systematic review and meta-analysis

Nephrectomy is standard for kidney tumors and living kidney donation, but postoperative chronic kidney disease (CKD) is a critical determinant of long-term outcomes. Risk factors for incident CKD after unilateral nephrectomy remain incompletely synthesized. PubMed, Embase, Web of...

Abdominal fat thickness predicts the risk of pregnancy-associated hypertension: A prospective cohort study.

BACKGROUND AND OBJECTIVES: Pregnancy-associated hypertension (PAH) is a prevalent complication during pregnancy. Maternal obesity is a known risk factor for PAH. As nutrition is a key modifiable driver of obesity and metabolic health, this study aimed to evaluate whether early-pr...

A mitochondria-related 9-gene induced sputum signature for severe asthma: an integrative transcriptomic analysis with external validation

OBJECTIVE: Severe asthma is biologically heterogeneous, and airway-derived biomarkers for disease stratification remain limited. We aimed to identify a mitochondria-related induced sputum transcriptomic signature associated with severe asthma. METHODS: Two public induced sputum m...

Post-injury high-sensitivity C-reactive protein to lymphocyte ratio and nonunion risk in adult extremity fractures: evidence from a multicenter retrospective cohort

Early immuno-inflammatory response serves a critical role in the process of fracture healing, and both excessive and insufficient activation after injury may predict adverse outcomes. This study aimed to investigate the association between post-injury high-sensitivity C-reactive...