Qingdao University

Neoadjuvant Anbenitamab and HB1801 in ERBB2 -Positive Breast Cancer

IMPORTANCE The combination of neoadjuvant taxanes with trastuzumab and pertuzumab remains the cornerstone treatment strategy in ERBB2 -positive breast cancer. Anbenitamab (a ERBB2 -biparatopic antibody that induces profound receptor clustering) and HB1801 (a solvent-free albumin-...

Diagnostic performance of ultrasound-derived fat fraction for detecting hepatic steatosis in patients with tumor-related liver disease

Accurate assessment of hepatic steatosis is crucial for preoperative risk stratification in patients with liver tumors. However, the diagnostic performance of the noninvasive ultrasound-derived fat fraction (UDFF) remains uncertain, where tissue heterogeneity can impair measureme...

Neurocognitive Changes and Cerebral Blood Flow in Patients with Symptomatic Carotid Artery Stenosis before and after Carotid Endarterectomy

Objective : Carotid endarterectomy (CEA) reduces stroke risk in carotid stenosis patients, with potential but unclear benefits on cognitive function and cerebral blood flow (CBF). This study aimed to assess cognitive and CBF changes after CEA in patients with transient ischemic a...

One vs twelve month aspirin after percutaneous coronary intervention for acute myocardial infarction: individual patient-data analysis of TARGET-FIRST and ULTIMATE-DAPT trials

Giuseppe Tarantini, Xiaojuan Zhang, Luca Nai Fovino, Jing Kan, Zhen Ge, Guillaume Cayla, Pieter C Smits, Benjamin Honton, Valeria Paradies, Yann Poezevara,

A Lyapunov‐Like Function‐Based Event‐Triggered Stabilization Scheme for Nonlinear Discrete‐Time Systems

ABSTRACT This study investigates stabilization methodologies utilizing event‐triggered mechanisms tailored for specific discrete‐time nonlinear systems. A Lyapunov‐like stability theorem is first established, which relaxes the conventional strict monotonic decrease constraint on...

A machine learning model for predicting early adverse outcomes after surgery in patients with early-onset rectal cancer: a two-center retrospective cohort study

Patients often present at advanced stages of early-onset rectal cancer (EORC), which is becoming more common. Within a year following rectal resection, some patients experience early adverse outcomes (EAO), such as severe complications, recurrence, or death; however, there is cur...

Single-cell and spatial transcriptomics reveal glycolytic remodeling and ENO1-associated metabolic vulnerability in hepatoblastoma

Hepatoblastoma (HB) is the most common malignant liver tumor in children; however, the contribution of glycolytic metabolic reprogramming to HB development and progression remains incompletely characterized. We integrated single-cell RNA sequencing and spatial transcriptomic data...

Comparison of transumbilical single-port and conventional multi-port laparoscopic hepatectomy for benign liver lesions

Transumbilical single-port laparoscopic hepatectomy represents a further refinement of minimally invasive liver surgery, but its safety and perioperative value remain insufficiently defined. This study aimed to compare transumbilical single-port laparoscopic hepatectomy with conv...

Development and validation of a multifeature-integrated nomogram for predicting postoperative survival in macrotrabecular-massive hepatocellular carcinoma

Macrotrabecular-Massive Hepatocellular Carcinoma (MTM-HCC) represents a highly aggressive histologic subtype associated with a poor prognosis. This study aimed to construct and validate a Multifeature-Integrated Nomogram model based on clinical, pathological, and imaging characte...

Targeting the Thy-1 mechanotransduction regulator rescues regenerative wound healing and induces hair follicle neogenesis under high tension

Abstract Mechanical tension is a critical driver of hypertrophic scar (HS) formation, primarily by inducing the differentiation of fibroblasts into pathological myofibroblasts. However, the upstream mechanotransduction regulators that initiate this fibrotic cell fate switch remai...

Moderate Food Preferences and Depression with Grey Matter as a Potential Mediator: A Large-Scale Longitudinal Study

Background: While stable dietary patterns and hedonic responses in food preferences are associated with depression, whether neurobiological mechanisms mediate this relationship remains unknown. This study therefore investigates the food preference–depression associations and thei...

Deep‐Learning‐Assisted Design of Dynamically Tunable Near‐Infrared Dual‐Band Lithium Niobate Metamaterial Absorber for Optical Communication

ABSTRACT To overcome the fixed operating wavelengths and limited tunability of conventional metamaterial absorbers, this study proposes a dynamically tunable near‐infrared dual‐band lithium niobate (LN) metamaterial absorber platform at optical communication wavelengths. Using an...

Hostile microenvironment-driven oxygenator hydrogel with spatiotemporally feedback regulated hif-1α for accelerating diabetic wound healing

Diabetic wounds remain notoriously intractable due to a hostile microenvironment characterized by hyperglycemia, hypoxia, and oxidative stress. However, existing therapies often lack the ability to autonomously and sustainably remodel this pathological niche. Herein, a smart nano...

Design, Fabrication, and Performance Study of 3D‐Printed Multi‐Tooth Interlocking Discrete Functionally Gradient Stretchable Substrates

ABSTRACT Flexible hybrid electronics (FHE), which integrate the deformation capability of flexible substrates with the functional stability of rigid components, show broad application prospects in wearable devices and aerospace fields. Among these, functionally graded substrates...

Electronic Conductivity as a Rate‑Limiting Factor for Calcium‑Ion Storage in Layered Vanadium Oxides

ABSTRACT Rechargeable calcium batteries are promising for sustainable energy storage but lack cathode materials that reversibly intercalate Ca 2+ at practical rates. While considerable efforts have focused on improving ionic conductivity, this work investigates how electronic con...

Phosphorothioate-Enabled Cas12a Autocatalytic Networkfor Amplification-Free Ultrasensitive Nucleic Acid Detection

Abstract Autocatalytic CRISPR/Cas systems offer a promising route toward amplification-free nucleic acid detection, yet their performance is limited by indiscriminate transcleavage of ssDNA activators and the reliance on structurally complex, thermodynamically unstable DNA archit...

Study on the pathogenic mechanisms and clinical treatment of advanced glycation end products (AGEs) in diabetic complications

The accumulation of Advanced Glycation End Products (AGEs), resulting from the Maillard Reaction formed via exogenous intake from food and a hyperglycemic internal environment in the body, can cause or exacerbate various complications of Diabetes Mellitus. This article discusses...

Soil microbial community structure and assembly are more strongly associated with soil background nitrogen content than by short-term nitrogen addition in a salt marsh

Soil microbes drive nutrient cycling, and microbial community composition and assembly are often shaped by plant succession and environmental heterogeneity. Nitrogen (N) is a vital nutrient for microorganisms, yet it remains unclear whether microbial responses to elevated N input...

Morphological and Size‐Dependent Enrichment of Endotoxins in Coastal Spray Aerosols: Implications for Regional Respiratory Health Risks

Abstract Sea spray aerosols (SSA) transport bioactive substances that affect the Earth's environmental and climate system. We investigated the enrichment of endotoxins (LPS), characterized their influence on the SSA morphologies, and evaluated the respiratory tract deposition. LP...

Acridine-Based[68Ga]Ga- and [18F]AlF-Labeled PSMA RadiotracersEnabling High-Contrast PET Imagingwith Minimized Undesired Retention

Abstract Prostate-specific membrane antigen (PSMA)-targeted radioligands have achieved clinical success in prostate cancer imaging, yet nonspecific uptake in normal tissues remains a challenge. Here, we developed a series of acridine-based PSMA ligands and systematically investig...