Qingdao University

Design, Fabrication, and Performance Study of 3D‐Printed Multi‐Tooth Interlocking Discrete Functionally Gradient Stretchable Substrates

ABSTRACT Flexible hybrid electronics (FHE), which integrate the deformation capability of flexible substrates with the functional stability of rigid components, show broad application prospects in wearable devices and aerospace fields. Among these, functionally graded substrates...

Hostile microenvironment-driven oxygenator hydrogel with spatiotemporally feedback regulated hif-1α for accelerating diabetic wound healing

Diabetic wounds remain notoriously intractable due to a hostile microenvironment characterized by hyperglycemia, hypoxia, and oxidative stress. However, existing therapies often lack the ability to autonomously and sustainably remodel this pathological niche. Herein, a smart nano...

Electronic Conductivity as a Rate‑Limiting Factor for Calcium‑Ion Storage in Layered Vanadium Oxides

ABSTRACT Rechargeable calcium batteries are promising for sustainable energy storage but lack cathode materials that reversibly intercalate Ca 2+ at practical rates. While considerable efforts have focused on improving ionic conductivity, this work investigates how electronic con...

Soil microbial community structure and assembly are more strongly associated with soil background nitrogen content than by short-term nitrogen addition in a salt marsh

Soil microbes drive nutrient cycling, and microbial community composition and assembly are often shaped by plant succession and environmental heterogeneity. Nitrogen (N) is a vital nutrient for microorganisms, yet it remains unclear whether microbial responses to elevated N input...

Study on the pathogenic mechanisms and clinical treatment of advanced glycation end products (AGEs) in diabetic complications

The accumulation of Advanced Glycation End Products (AGEs), resulting from the Maillard Reaction formed via exogenous intake from food and a hyperglycemic internal environment in the body, can cause or exacerbate various complications of Diabetes Mellitus. This article discusses...

Phosphorothioate-Enabled Cas12a Autocatalytic Networkfor Amplification-Free Ultrasensitive Nucleic Acid Detection

Abstract Autocatalytic CRISPR/Cas systems offer a promising route toward amplification-free nucleic acid detection, yet their performance is limited by indiscriminate transcleavage of ssDNA activators and the reliance on structurally complex, thermodynamically unstable DNA archit...

Acridine-Based[68Ga]Ga- and [18F]AlF-Labeled PSMA RadiotracersEnabling High-Contrast PET Imagingwith Minimized Undesired Retention

Abstract Prostate-specific membrane antigen (PSMA)-targeted radioligands have achieved clinical success in prostate cancer imaging, yet nonspecific uptake in normal tissues remains a challenge. Here, we developed a series of acridine-based PSMA ligands and systematically investig...

On the Bottom‐Up Construction of Many‐Electron Relativistic QED Hamiltonian

ABSTRACT It was shown more than a decade ago [J. Chem. Phys. 139, 014108 (2013)] that a many‐electron relativistic quantum electrodynamics (QED) Hamiltonian for high‐precision electronic structure calculations can be constructed in a bottom‐up fashion, by virtue of charge‐conjuga...

Morphological and Size‐Dependent Enrichment of Endotoxins in Coastal Spray Aerosols: Implications for Regional Respiratory Health Risks

Abstract Sea spray aerosols (SSA) transport bioactive substances that affect the Earth's environmental and climate system. We investigated the enrichment of endotoxins (LPS), characterized their influence on the SSA morphologies, and evaluated the respiratory tract deposition. LP...

Mefatinib versus gefitinib as a first-line treatment for EGFR-mutated non-small cell lung cancer: a randomized, double-blind, multicenter phase III study

Mefatinib, a novel second-generation epidermal growth factor (EGFR) tyrosine kinase inhibitor that has shown promising antitumor activity in targeting non-small cell lung cancer (NSCLC) with common and uncommon EGFR- activating mutations. In this phase III, randomized, double-bli...

Analysis of birefringence modulation performance in RM-embedded CO-polymer waveguides

Uncontrolled birefringence causes measurement errors and signal distortion in high-precision optical systems, yet existing modulation methods suffer from complex fabrication or poor stability. Polymer waveguides serve as low-cost, flexible alternatives to traditional lithium niob...

A Multifunctional Finishing Strategy for Lyocell Fabric Integrating Durable Flame Retardancy and Enhanced Dyeing Performance via One‐Bath Process

ABSTRACT In our previous work, a fully bio‐based flame retardant (PALA) was synthesized from phytic acid and L‐arginine and applied to Lyocell fabric, significantly enhancing its flame retardancy and washing durability. This study further develops a one‐bath synergistic process i...

Activating Cannabinoid receptor 2 alleviates iron overload-induced liver damage via dual modulation of STAT3/hepcidin and Nrf2/FPN1 pathways

Iron overload-related liver injury is a major clinical problem in hereditary hemochromatosis, transfusional siderosis, and chronic liver diseases, yet current treatments such as iron chelation therapy and phlebotomy are limited by safety and efficacy issues. Cannabinoid receptor...

Landscape Ecological Risk Evolution and Its Nonlinear Driving Mechanisms in a Topographically Constrained River-Valley Basin: A Case Study of the Taiyuan Section of the Fen River Basin

In regions where severe topographic constraints coincide with intensive human activity, the mechanisms underlying landscape ecological risk (LER) and its spatial differentiation remain poorly understood. In particular, the nonlinear responses and threshold effects arising from th...

Estimating individualized gonadotropin starting doses in women with PCOS: a target-driven machine learning model for GnRH-antagonist stimulation

Abstract Background Women with polycystic ovary syndrome (PCOS) are prone to excessive ovarian response and ovarian hyperstimulation syndrome (OHSS) during controlled ovarian stimulation, whereas overly conservative gonadotropin (Gn) dosing reduces oocyte yield and efficiency. Th...

Microfluidic engineering of CeO2/Peptide nanosheet-integrated bioactive hydrogel microspheres for multi-enzymatic biomimetic catalytic therapy of osteoarthritis

Osteoarthritis (OA) is a degenerative joint disease characterized by chronic inflammation and oxidative stress-induced cartilage degeneration, yet effective disease-modifying therapies remain limited. Herein, we report a CeO 2 /peptide nanosheet (CeP)-integrated hydrogel microsph...

Rapid Non-Destructive Mango Variety Identification Using Multi-Scale Global Context Network with NIR Spectroscopy

Accurate identification of mango varieties holds substantial significance for the elevation of product added value and the facilitation of market differentiation through quality-based pricing. Near-infrared (NIR) spectral analysis offers a rapid, non-destructive solution for mang...

Holistic Inside‐Out Reconfiguration of Ni‐Rich Cathodes via a Thermally Self‐Driven Strategy for Exceptional Chemomechanical Stability

ABSTRACT Ni‐rich layered oxides (LiNi x Co y Mn 1− x − y O 2 , x ≥ 0.8) are indispensable for high‐energy‐density lithium‐ion batteries, yet they suffer from severe chemomechanical degradation driven by the synergy of internal microcracking and interfacial parasitic side reaction...

Macrophage-derived IL-1β drives endothelial-mesenchymal transition in diabetes mellitus erectile dysfunction

Diabetes mellitus erectile dysfunction (DMED) is frequently accompanied by corpus cavernosum (CC) fibrosis and endothelial dysfunction; however, the cellular drivers and molecular mechanisms underlying these pathological changes remain incompletely understood. Endothelial-to-mese...

Neural regulation in lung cancer: from mechanisms to new therapeutic perspectives

Lung cancer remains a leading cause of cancer-related deaths worldwide. Despite advances in targeted therapy and immunotherapy, treatment outcomes are often constrained by tumor heterogeneity and the complex tumor microenvironment. Recent studies highlight the critical role of th...