Pennsylvania State University

BEAR-GRN: Systematic assessment of single-cell multi-omics-based gene regulatory network inference methods

Identifying regulatory gene interactions is inherently challenging as it depends on both the transcriptional and epigenetic landscapes. Multiple methods are proposed to infer gene regulatory networks (GRNs) using single-cell multi-omics data, yet the absence of a standardized ben...

Fulminant Amyloid-β–Related Angiitis after Tenecteplase: A Biopsy-Confirmed Cause of Post-Thrombolysis Neurologic Deterioration

Background Amyloid-β–related angiitis (ABRA) is a rare steroid-responsive inflammatory vasculopathy that can mimic or complicate acute cerebrovascular disease. Its interaction with thrombolytic therapy is poorly understood. We report a biopsy-confirmed case of fulminant ABRA temp...

How Much Physics Should a Neural Network Know? Thermodynamics‐Informed Neural Networks for Rock Constitutive Modeling With Epistemic Uncertainty

Abstract Machine learning offers a flexible route to constitutive modeling, with two emergent questions for geoscience applications: what level of thermodynamic constraint should be embedded in the network architecture, and how should predictive uncertainty be quantified when ext...

Finite-Element-Guided Design of Metallic and Bioresorbable Bone Screws: Linking Thread Geometry, Material Stiffness, and ACL Screw Mechanics

Abstract Bone screw fixation is governed by the thread geometry, material stiffness, contact friction, and loading path. Here, a staged finite-element workflow was used to screen bone-screw designs for bone-to-bone and ACL fixation. Two-dimensional models rapidly compared thread...

Data-driven modeling of spatiotemporal dynamics using multimodal imaging data

Understanding how biological systems evolve across space and time remains a fundamental challenge, particularly when dynamic processes vary substantially across individuals. We present a personalized graph-based dynamical modeling framework for characterizing spatiotemporal biolo...

Precision Diagnosis of Apple Leaf Diseases Across Infection Stages via Web-Based Analysis

Abstract Purpose Throughout the growing season, leaf diseases pose a huge risk to apple fruit yield and quality. While early detection targets timely intervention, understanding disease progression across different stages is essential for effective treatment and resistance breedi...

Trends and disparities in cannabis use disorder-coded inpatient discharges across 18 U.S. states, 2005–2023

Objective Prior studies document rising cannabis use disorder (CUD) prevalence and disparities, but less is known about trends in CUD-coded inpatient discharges across populations and intersecting sociodemographic groups. We examined trends and variation in CUD-coded inpatient di...

High-fidelity spatiotemporal evolution of CO₂ storage in saline aquifers: A physics-synergized deep learning framework for CO₂ plume prediction and super-resolution reconstruction

Abstract Precise forecasting of spatiotemporal CO₂ plume evolution in deep saline aquifers is imperative for ensuring the long-term integrity and efficacy of carbon capture and storage. However, a persistent dichotomy exists in current modeling paradigms: high-fidelity numerical...

Isolation and Characterization of Lytic Bacteriophages Targeting Clinical Staphylococcus Other Than S. aureus

Abstract Staphylococcus spp., other than S. aureus (SOSA, formerly CoNS), are opportunistic pathogens often linked to biofilm infections on indwelling devices. Their rising antibiotic resistance highlights the need for novel therapies. Bacteriophages are promising due to their sp...

Perceived Discrimination and Cognitive Function Among Older Adults: An Analysis of the Health and Retirement Study

Abstract Background Cognitive aging is a major public health concern, and cognitive health disparities disproportionately affect racially and ethnically minoritized communities. Perceived everyday discrimination has been proposed as a contributor to disparities in cognitive funct...

Large‐scale nuclear and plastid phylogenomic analyses inform an updated Angiosperm Phylogeny Group classification: APG V

Abstract We present here a revision of the APG classification that considers the extensive recent analyses of hundreds of nuclear and plastid genes for many angiosperm species. Although previous versions of the APG classification were largely based on uniparentally inherited mark...

Reframing vaccine safety: recognizing mass psychogenic illness as an adverse event following immunization

Abstract Diagnoses of mass psychogenic illness (MPI) following vaccination usually occur after the failure of all efforts to find a plausible biological mechanism for the collective reaction to the vaccine in question. They are experienced as waste-basket diagnoses that leave suf...

The chromosomal genome sequence of the boulder star coral, Orbicella franksi (Gregory, 1895) (Scleractinia: Merulinidae)

We present a genome assembly from a specimen of Orbicella franksi (boulder star coral; Cnidaria; Anthozoa; Scleractinia; Merulinidae). The genome sequence has a total length of 496.97 megabases. Most of the assembly (95.24%) is scaffolded into 15 chromosomal pseudomolecules. The...

Evidence for an inflammatory contribution to cutaneous microvascular endothelial dysfunction in non-Hispanic Black women

Non-Hispanic Black (NHB) adults demonstrate impaired microvascular endothelial function, characterized as reduced nitric oxide (NO)-mediated vasodilation, compared to non-Hispanic White adults. A sexual dimorphism exists, where microvascular dysfunction in NHB men is mediated thr...

Multiplex K-Edge Nanoprobe Imaging Enables 3D Volumetric Molecular Phenotyping of Human Hematoma Membranes

Abstract Spectral photon-counting computed tomography (SPCCT) enables material-resolved imaging through K-edge discrimination, yet its application to multiplexed molecular mapping of human surgical specimens remains underexplored. Here, we report a clinically relevant multiplex K...

4D printing modular twisting metamaterials with reprogrammable functionality and reconfigurable deformation

Developing torsional mechanical metamaterials capable of delivering reconfigurable and adaptive responses through compression-torsion coupling remains a significant challenge. Here, we present a bioinspired multifunctional twisting mechanical metamaterial (MTMM) featuring a modul...

Linking public and private neuroimaging data with decentralized analysis via NeuroFLAME Vaults

Large-scale datasets and global collaborations are increasingly enabling exciting discoveries in neuroimaging research; however, barriers such as data privacy regulations and unequal access to computational infrastructure continue to hinder progress. Federated analysis offers a p...

Building Science Performance of 3D-Printed Concrete Walls: A Review of Thermal and Hygrothermal Properties

The use of 3D-printed concrete (3DPC) for home building has been of interest to several newly formed 3D printing companies over the past few years. This interest is largely due to its time and material efficiency, as well as its flexibility in architectural design. Although the s...

Speciation-Dependent Iron Uptake Drives Biofortification Efficiency and Nutritional Quality in Radish and Pea Microgreens

Abstract In plants and humans, adequate levels of iron (Fe) are essential for proper growth and development. Dietary deficiencies in Fe are particularly prevalent and can cause numerous physical and cognitive impairments in humans. Intervention strategies like agronomic biofortif...

Embracing the DIGNITY of Resident Relationships: A Case Study of the Decision-Making in Aging and Dementia for Autonomy (DIGNITY) Protocol

Public policies governing U.S. nursing homes emphasize resident rights, autonomy, and person-centered care, yet translating these principles into everyday practice remains challenging – particularly for residents living with dementia whose preferences involve perceived risk. Regu...