Peking University Third Hospital

Clinical and radiographic outcomes of second molars with external root resorption following impacted third molar removal: a retrospective CBCT-based cohort study

To evaluate the clinical and radiographic outcomes of second molars (M2s) affected by external root resorption (ERR) following impacted third molar (M3) removal, and to assess the influence of adjunctive guided bone regeneration (GBR). This retrospective cohort study included pat...

Active commuting and biological aging: Cross-sectional evidence from the UK Biobank

Objective To investigate whether commuting mode is associated with biological aging, including KDM 's Biological Age Acceleration (KDM-BAA), PhenoAge Acceleration (PhenoAA) and leukocyte telomere length (LTL) based on the UK Biobank (UKB). Methods We performed a cross-sectional s...

A durably colonising engineered native symbiont enables sustained intestinal delivery for metabolic dysfunction and colitis

Background Engineered bacterial therapeutics represent a promising strategy for sustained intestinal delivery of therapeutic molecules, but their efficacy is limited by inefficient colonisation, safety concerns and the need for repeated administration or auxiliary delivery system...

Onvansertib-mediated PLK1 inhibition impairs spermatogenesis in the murine testis

Onvansertib (ONV) is a selective inhibitor of polo-like kinase 1 (PLK1) and has promise in treating cancer. However, its potential effects on male reproductive function remain insufficiently characterized. In this study, male mice received clinically relevant doses of ONV by intr...

SCFJFK regulates osteoblast differentiation through targeting RUNX2

RUNX2 (Runt-related transcription factor 2) is a master regulator of osteogenesis, and its genetic mutations are associated with ~65% cases of cleidocranial dysplasia (CCD), an autosomal dominant abnormal bone development disorder in humans with defective intramembranous bone for...

Circumferential pulmonary vein isolation (CPVI) with adjunctive linear ablation vs. CPVI alone for long-standing persistent atrial fibrillation (SINUS): study protocol for a prospective, multi-center, randomized controlled trial

Previous studies have shown that circumferential pulmonary vein isolation (CPVI) alone has a relatively lower success rate for long-standing persistent atrial fibrillation (LSPAF). This study aims to compare the efficacy and safety between CPVI combined with modified linear ablat...

Bone aging: a paradigm of multiscale degeneration and targeted rejuvenation

Bone aging is not merely a process of bone mass loss but rather a multi-level, networked degenerative phenomenon spanning molecular, cellular, tissue, and system levels. With the accelerating pace of global population aging, bone degenerative diseases have emerged as a major publ...

Utilization of Carbon Fiber Spinal Instrumentation in Primary Spinal Tumors: Outcome Analysis from the AO Spine Primary Tumor Research and Outcomes Network

Background The use of carbon fiber-reinforced polyetheretherketone (CFR-PEEK) instrumentation in spinal surgery has emerged as an alternative to traditional titanium-based implants in recent years. This study aims to evaluate the use and performance of carbon fiber instrumentatio...

Deep learning predicts gene rearrangements from histopathology in large B-cell lymphoma

Abstract Large B-cell lymphomas are molecularly heterogeneous mature B-cell neoplasms in which assessment of MYC , BCL2 , and BCL6 rearrangement status contributes to integrated diagnosis, risk stratification, and treatment planning. Fluorescence in situ hybridization (FISH) rema...

Early weight bearing with ultrasound monitoring is associated with accelerated functional recovery after open repair of acute achilles tendon rupture: a retrospective cohort study

Optimal rehabilitation after open repair of acute Achilles tendon rupture (AATR) remains controversial. Early weight-bearing may enhance recovery, but its clinical use is limited by lack of objective criteria. This study evaluated the safety and efficacy of an ultrasound-monitore...

Clinical and imaging characteristics of cervical ossification of the posterior longitudinal ligament and factors influencing its severity: a retrospective cross-sectional study

Abstract Background Although the prevalence of cervical ossification of the posterior longitudinal ligament (OPLL) and its risk factors for onset and postoperative progression have been well documented, a comprehensive profile of patients with this condition remains lacking, and...

Regional alterations in bone microstructure, muscle, and fat of the knee following anterior cruciate ligament rupture: a laboratory study in rabbit model

To investigate the temporal alterations in bone, muscle, and fat tissues in an anterior cruciate ligament transection (ACLT) rabbit model. A total of 24 male New Zealand White rabbits underwent ACLT in the right knee. The animals were euthanized at 3, 6, 9, and 12 weeks post-ACLT...

Epididymal Versus Testicular Sperm for ICSI in Obstructive Azoospermia: Embryological, Clinical, and Neonatal Outcomes in a Retrospective Cohort

BACKGROUND: Whether sperm source influences intracytoplasmic sperm injection (ICSI) outcomes in men with obstructive azoospermia (OA) remains uncertain. OBJECTIVE: To compare embryological, clinical, and neonatal outcomes of ICSI using percutaneous epididymal sperm aspiration (PE...

A multimodal deep learning method based on multiple medical images for Fuchs endothelial corneal dystrophy diagnosis

To establish a multimodal deep learning network for the automated diagnosis of Fuchs endothelial corneal dystrophy (FECD). The ResNet-50 neural network was trained and validated using patients with FECD, patients with other corneal endothelial disorders, and healthy controls. At...

Recent advances in delivery strategies for CRISPR-based genome editing

Abstract The rapid development of CRISPR genome editing technologies has established a transformative paradigm within biomedical research, drug discovery, and gene therapy. Despite the robust nuclease activity and programmable targeting exhibited by these systems, the clinical tr...

Multifunctional CuSbS2 Nanocrystals as an Integrated Flexocatalytic–Photocatalytic–Nanozymatic Platform for Antibacterial Therapy

Abstract Ultrasound-enabled catalytic strategies offer a non-invasive route for antibacterial therapy but are typically limited to non-centrosymmetric piezoelectric materials. Herein, we developed ultrasound-assisted flexocatalysis as a symmetry-independent approach for reactive...

Longitudinal blood pressure trajectories before 20 weeks of gestation and adverse outcomes in women with chronic hypertension

OBJECTIVE: To explore the different patterns in early-pregnancy mean arterial pressure (MAP) trajectories before 20 weeks of gestation in pregnant women with chronic hypertension, and whether it can stratify risk for adverse perinatal outcomes. METHODS: We conducted a retrospecti...

Macrophage FOXO1 Inhibition Protects Against Hyperglycaemia‐Associated Kidney Injury

ABSTRACT Diabetic kidney disease (DKD) is one of the most significant microvascular complications of diabetes, characterized by high incidence and mortality; however, its pathogenesis remains unclear. Renal inflammation and macrophage infiltration play pivotal roles in driving DK...

The illusion of clinical reasoning: a benchmark reveals the pervasive gap in vision-language models for clinical competency

The rapid integration of foundation models into clinical practice and their use for public health inquiries necessitates a rigorous evaluation of their true clinical reasoning capabilities, which extends beyond success on narrow examinations. Current benchmarks, often based on me...

Clinical value of the endoscopic scratch sign in diagnosing Helicobacter pylori infection status

Accurate assessment of Helicobacter pylori ( H. pylori ) infection status is essential for clinical decision-making. This study aimed to evaluate the clinical utility of the endoscopic scratch sign which refers to linear reddish streaks observed along the greater curvature of the...