Peking University Third Hospital

Immune checkpoint inhibitor-associated acute interstitial nephritis: Pathogenesis and heterogeneity

Immune checkpoint inhibitor (ICI)-associated acute kidney injury is a significant complication of cancer immunotherapy, with acute interstitial nephritis (AIN) being the most common pathological type. This review systematically elaborates on the core pathogenesis, spectrum of pat...

A Tumor-Microenvironment-Responsive Chemically MaskedIL-2 Prodrug Potentiates PD-1 Checkpoint Blockade andElicits Robust Antitumor Efficacy

Abstract Interleukin-2 (IL-2) is a potent mediator of T-cell activation with significant potential for cancer immunotherapy, yet its clinical utility is severely constrained by its narrow therapeutic window. Here we report a chemically masked IL-2 prodrug (Cm-proIL2) that enables...

Emerging Trends in the Incidence (1999–2022) and Mortality (1999–2023) of Thyroid Cancer in the United States: CDC WONDER Database Study

Background: Thyroid cancer (TC) is a common endocrine malignancy with a rising global incidence. This study examined trends in TC incidence and mortality in the United States over the past two decades. Methods: TC mortality data from 1999-2023 and incidence data from 1999-2022 we...

Machine learning-based fall risk prediction in community-dwelling older adults using dual-task spatiotemporal gait parameters

With global aging, falls have become a major threat to geriatric health. Traditional clinical assessments often suffer from a “ceiling effect,” failing to detect subtle motor impairments in high-functioning older adults. Moreover, steady-state gait analysis lacks ecological valid...