Peking University Third Hospital

Maximal Outcome Improvements Predict Patient Satisfaction After Autologous Osteoperiosteal Transplantation for Cystic Osteochondral Lesions of the Talus, With Body Mass Index and Plug Number Associated With Threshold Achievement

PURPOSE: To determine maximal outcome improvement (MOI) thresholds for patient-reported outcome measures and identify predictors of achieving them after autologous osteoperiosteal transplantation (AOPT) for cystic osteochondral lesions of the talus. METHODS: Patients with Hepple...

Association of a mobile health HH model intervention with BMI changes in office employees: a sex‑stratified prospective non‑randomized controlled cohort study

This study examined the associations of a novel mobile health model integrating the Health Action Process Approach (HAPA) with comprehensive health management strategies, termed the HH model, with body mass index (BMI) and metabolic outcomes among office employees, with a focus o...

Golgi disassembly: a key process for autophagy-mediated regulation of oocyte spindle migration

Although the Golgi apparatus undergoes extensive disassembly during mitosis to ensure its equitable partitioning into two daughter cells, the extreme asymmetry of oocyte meiosis obviates this need, raising fundamental questions about the existence and necessity of Golgi disassemb...

Remote‐Controlled Genetic Circuits: Light, Ultrasound, and Magnetic Fields for Programmable Gene Regulation

Remote-controlled genetic circuits use externally applied physical signals to regulate gene expression and cellular functions with spatial and temporal precision. Light, ultrasound, and magnetic fields provide complementary advantages in controllability, tissue accessibility, and...

Mass-momentum synergistic transport criterion in gravity-controlled closed phase-change systems: Numerical validation using nanofluid-enhanced heat pipes

In closed phase-change heat transfer system under gravitational control, the essence of coordinating the material basis (mass source) and the driving potential (momentum source) to maintain efficient circulation dynamics lies in the fact that the geometric topology of the liquid...

Precision targeting and alternative effector cells: Revolutionizing CAR-based therapy for T-cell malignancies.

T-cell malignancies are highly heterogeneous and associated with high relapse rate and poor prognosis. While chimeric antigen receptor-T (CAR-T) cell therapy has achieved remarkable success in relapsed or refractory B-cell malignancies, its application in T-cell malignancies rema...

Pola-R-CHP in previously untreated DLBCL with international prognostic index score 0–1: a multicenter real-world retrospective study in China

Abstract Purpose Approximately 30% of newly diagnosed diffuse large B-cell lymphoma (DLBCL) cases are categorized as low-risk by the international prognostic index (IPI). Polatuzumab vedotin, rituximab, cyclophosphamide, doxorubicin, and prednisone (Pola-R-CHP) has demonstrated e...

Characteristics of p53 and Smad4 immunohistochemistry in pancreatic ductal adenocarcinoma and validation by next-generation sequencing.

BACKGROUND: has been extensively adopted in routine pathology practice. However, standardized IHC pattern classification schemes and rigorous validation of their predictive accuracy for underlying genomic alterations remain lacking in PDAC. METHODS: mutations was rigorously evalu...

Integrated metabolomic and targeted lipidomic profiling reveals systemic metabolic dysregulation in the follicular microenvironment of polycystic ovary syndrome

Polycystic ovary syndrome (PCOS) is a prevalent endocrine and metabolic disorder that significantly impacts female fertility. The follicular microenvironment, particularly follicular fluid (FF), plays a critical role in oocyte development, yet the systemic metabolic dysregulation...

Association of depressive symptoms with retinal layer thickness: insights from the population-based Beijing eye study 2011

The aim of this study is to investigate the association between depressive symptoms and retinal layer thickness in a population-based adult Chinese cohort. This population-based, cross-sectional study included 2127 eyes of 2127 participants of Beijing Eye Study 2011, free of any...

Gestational Changes in Placental Iron Homeostasis are Associated With Ferroptosis‐Associated Redox Signaling and Trophoblast Behavior

Well-regulated trophoblast proliferation, migration, invasion, and cell turnover are essential for normal placental development in humans and rodents. Given the established role of oxidative stress in placentation and the redox activity of iron, we investigated whether ferroptosi...

A physics-guided neural framework for rheology measurement from dynamical laser speckles

Unlocking new frontiers in biomedicine and materials science requires rapid, non-destructive viscoelastic characterization of soft matter in its native state. Laser Speckle Rheology (LSR) has emerged as a transformative optical solution, fundamentally circumventing the invasive a...

Staged and Simultaneous Bilateral Hip Arthroscopy for Femoroacetabular Impingement Syndrome Achieves Clinical Outcomes Comparable With Unilateral Surgery at a Minimum 2‐Year Follow‐Up: A Systematic Review

Purpose To synthesize the available evidence comparing patient‐reported outcomes and reoperation rates between bilateral and unilateral hip arthroscopy in patients with femoroacetabular impingement syndrome, irrespective of whether bilateral procedures were performed in a staged...

Femtosecond laser photoporation enables efficient delivery of apoptotic vesicles for enhanced osteogenesis

Abstract A major barrier to the translation of vesicle-based therapeutics in regenerative medicine is the ability to achieve efficient intracellular delivery without compromising, and ideally amplifying, biological activity. As a bioactive class of cell-derived vesicles with pro-...

Benign nature of incidental orbital uptake on bone scintigraphy: insights from multi-modality imaging and follow-up

To characterize incidental orbital radionuclide uptake on bone scintigraphy using multi-modal imaging and follow-up. This retrospective study included 66 patients with focal orbital uptake on whole-body bone scintigraphy (2019–2022). Subsets underwent follow-up bone scintigraphy...

In Vitro Activity of Imipenem/Relebactam and Ceftolozane/Tazobactam Against Multidrug-Resistant Klebsiella pneumoniae: A Retrospective Single-Center Study in China

Background: Multidrug-resistant Klebsiella pneumoniae (MDR-KP) is a global health threat with limited treatment options. Comparative in vitro data for imipenem-relebactam (I/R) and ceftolozane-tazobactam (C/T) across diverse MDR-KP clinical populations remain limited. Methods: Su...

Caspase-11-mediated non-canonical pyroptosis is a key mechanism of alveolar epithelial cell injury in LPS-induced ARDS

Alveolar epithelial cells (AECs) injury is a critical event in the pathogenesis of acute respiratory distress syndrome (ARDS); however, the underlying mechanisms remain complex, and it is still unclear which cell death or inflammatory pathway predominates. In this study, we analy...

Retinoic acid maintains the primordial follicle reserve by inhibiting PI3K/Akt signaling

In female mammals, nonrenewable primordial follicles are orderly activated to maintain reproductive lifespan. However, the initiating regulator(s) of primordial follicle maintenance and activation remain poorly characterized. RA synthesis enzymes were mainly expressed in the pre-...

The association between passive anterior tibial subluxation and anterior cruciate ligament reconstruction failure

Abstract Purpose Increased passive anterior tibial subluxation (PATS) has been observed in patients with failed anterior cruciate ligament (ACL) reconstruction (ACLR). However, whether primary PATS is associated with future risk of graft failure and how PATS evolves over time rem...

Parenting styles and fertility intention: Mediating effects of childbearing beliefs and psychological resilience

China's declining fertility rate is partly due to low fertility intention among childbearing population. To understand family influence on young people's fertility intention and its underlying mechanisms, this study examines how parenting styles (authoritarian vs. permissive) aff...