Newcastle University

Long-term outcomes of indeterminate breast (B3) lesions managed with vacuum-assisted excision

Abstract Background UK guidelines for indeterminate (B3) breast lesions recommend vacuum-assisted excision (VAE) over diagnostic surgery. However, there is little long-term follow-up published post VAE management. This study evaluates immediate and long-term outcomes of women wit...

Mental health effects of the universal credit rollout 2009–2019 on adults with dependent children: evidence from the UK household longitudinal survey

Background: Universal Credit (UC) is the UK’s largest recent welfare reform intended to streamline the benefits system and improve work incentives. However, UC features, including sanctions and work-related conditionality, may undermine financial security and harm mental health....

Impact of renewable biomass addition on carbon structure evolution during metallurgical cokemaking assessed by multi-scale spectroscopy

Partial substitution of metallurgical coal with renewable biomass may reduce fossil carbon input in cokemaking, but its influence on carbon ordering during pyrolysis remains unclear. Fixed 10 wt-% additions of microalgae (MA) and torrefied bamboo (TB) were blended with two Austra...

When two worlds collide – the experiences of academic and Local Authority teams in implementing a cluster randomised control trial to test the impact of the MapMe tool on child healthy weight maintenance: a qualitative study

Aims: Little is known about Local Authority (LA) teams’ involvement in and delivery of research trials. The National Childhood Measurement Programme (NCMP) measures the weight status of 4- to 5- and 10- to 11-year-olds and communicates the results to parents, via letter. However,...

Genome-wide synthetic lethality screen of Bam complex-associated genes in Escherichia coli

Abstract Biogenesis of the bacterial outer membrane is key to bacterial survival and antibiotic resistance. Central to this is the β-barrel assembly machine (Bam) complex and its associated chaperones, which are responsible for transport, folding and insertion of outer membrane p...

Influence of Polymer Hydrophilicity on Solvent-Driven Rare-Earth Element Binding Thermodynamics and Heat Capacity Changes

Abstract Rare-earth elements (REEs: La–Lu, Y, Sc) are critical to modern technology; however, their acquisition, purification, and separation from each other can be challenging, and current methods are often environmentally damaging. Metal-binding polymers are a promising materia...

Third place visiting among mid-to-older adults: a cross-classified multilevel analysis

Background Visiting ‘third places’ outside of the home or workplace is associated with better health. For mid-to-older adults, visiting third places provides opportunities for social connectedness and physical activity that can support healthy ageing. We aimed to identify factors...

‘Am I going to be forced to have an Irish passport?’: A qualitative study of Brexit and identity in Northern Ireland

Matters of identity in Northern Ireland are often premised on the idea of a neatly bipartite, constitutional division, yet academic scholarship reflects a more complex reality. Expressions of national and cultural affiliations have evolved, particularly in the decades since the B...

A call for action with the burden of cirrhosis in Australia

Unlike most other chronic diseases and cancers in Australia, outcomes for cirrhosis and hepatocellular cancer are not improving. Public hospitals are overwhelmed by decompensated cirrhosis and struggling to provide best practice care for the large population of patients with less...

Amphiphilic Non‐Isocyanate Polyurethane Coatings With Tunable Antifouling and Fouling‐Release Performance: A Log‐Ratio Assessment Framework

ABSTRACT This study investigates amphiphilic non‐isocyanate polyurethane (NIPU) coatings containing reactive hydrophobic poly(dimethylsiloxane) (PDMS) and hydrophilic methoxy poly(ethylene glycol) (MPEG) prepolymers for marine antifouling (AF) and fouling‐release (FR) application...

Public knowledge, barriers and facilitators to UK dietary guideline adherence: a nationally representative survey

Abstract Aim Adherence to UK dietary guidelines is poor, yet no evidence exists regarding population-level knowledge of these guidelines, or the barriers and facilitators to adherence. This study aimed to characterise knowledge of UK dietary guidelines and perceived barriers and...

A global study of novel agents in paediatric and adolescent relapsed and refractory B-cell non-Hodgkin lymphoma (Glo-BNHL): protocol for an adaptive international platform clinical trial

The second Paediatric Strategy Forum of the international multi-stakeholder organisation, ACCELERATE (Nov-2017), concluded that an international approach to conducting clinical trials in relapsed and refractory paediatric B-cell non-Hodgkin lymphoma (r/r B-NHL) was critical and t...

Binarity at LOw Metallicity (BLOeM): massive star variability revealed using a novel software tool for point-spread function fitting of TESS images

Supporting data for peer-reviewed publication entitled: 'Binarity at LOw Metallicity (BLOeM): massive star variability revealed using a novel software tool for point-spread function fitting of TESS images'. For the purpose of open access, the authors have applied a CC BY licence...

Active Ingredients in Quantitative Dosage for Children With Phonological Impairment: A Scoping Review

BACKGROUND: Speech Sound Disorder (SSD) reduces speech intelligibility, affecting a child's ability to make themselves understood. If SSD is not resolved in the early years it will negatively impact children's education and general well-being. Effective and efficient speech and l...

OphthoEvidence Report: Comparative effects of treatments for geographic atrophy secondary to age-related macular degeneration: A protocol for a living systematic review and network meta-analysis

Background Geographic atrophy (GA), an advanced form of age-related macular degeneration (AMD), leads to legal blindness in approximately 16% of affected individuals within 6 years. Numerous trials have evaluated interventions to slow GA progression, and many studies are ongoing....

Impact of a Mediterranean diet and physical activity intervention on the gut microbiome and faecal metabolites: findings from the MedEx-UK randomised controlled trial

Abstract Diet and physical activity (PA) are potential modulators of the gut microbiome, although research findings are inconsistent, and few studies have explored their combined effects. This study used data from ninety-three participants (forty-seven with pre- and post-interven...

Mapping the evidence base of kidney, prostate and urinary tract tumours to inform the WHO classification of tumours

Background The project ‘World Health Organization (WHO) Classification of Tumours (WCT): a Living Evidence Gap Map by Tumour Type’ applies the Evidence and Gap Map (EGM) methodology to systematically synthesise evidence to support iterative refinements of the WCT. As part of this...

“Is it worth our time?” Understanding the educational culture of medical students and educators in addressing vaccine hesitancy

Abstract Background Vaccine uptake is declining, with vaccine hesitancy a primary cause. Although doctor recommendations are effective in influencing patient decisions, many lack confidence and skill in discussing hesitancy. This study examines how doctors and medical students pe...

From Assemblies to Institutions and Back Again? Cycles of Democracy and Representation in the Spanish Labour Movement

ABSTRACT Despite growing interest in union renewal, worker voice and new forms of labour organisation, industrial relations scholarship has paid limited attention to assemblies as an organisational form in their own right. This article argues that assemblies constitute a historic...

Spatially resolved multiomics of human meningeal development reveal lineage and disease dynamics

Abstract The meninges are increasingly recognized as key stromal and immune niches supporting cranial development. Here we constructed a paired single-nuclei RNA and Assay for Transposase-Accessible Chromatin atlas of human meningeal development from 6 to 21 postconception weeks...