Newcastle University

USP5 acts as a proteolytic switch to control SDE2 function via UBL-directed cleavage

Abstract Proteolytic processing is a fundamental regulatory mechanism in eukaryotic cells, yet the molecular identities and mechanisms underlying such events are often poorly defined. Silencing Defective 2 (SDE2), an essential human protein, plays important roles in mRNA splicing...

Optimal combination of composite likelihoods using approximate Bayesian computation with application to state-space models

Composite likelihood provides approximate inference when the full likelihood is intractable and sub-likelihood functions of marginal events can be evaluated relatively easily. It has been successfully applied for many complex models. However, its wider application is limited by t...

Adherence to the Eatwell Guide and associations with markers of adiposity: a prospective analysis within the UK Biobank cohort

Abstract Background Obesity remains a major public health concern in the UK, contributing towards increased disease risk and premature mortality. The Eatwell Guide - the UK’s health eating model - is widely applied in policy and practice, yet evidence linking adherence to this di...

Electrochemical click chemistry for controlled and localized biosensor surface functionalization

Biosensor performance depends strongly on the properties of the functionalized electrode interface, making robust and controllable surface modification strategies highly desirable. In this work, we investigate electrochemical click chemistry (E-click) as an electrochemically driv...

Solving the Gross-Pitaevskii equation with quantic tensor trains: Ground states and nonlinear dynamics

We develop a tensor network framework based on the quantic tensor train (QTT) format to efficiently solve the Gross-Pitaevskii equation (GPE), which governs Bose-Einstein condensates under mean-field theory. For sufficiently regular functions, the QTT approach enables exponential...

Stochastic Gassmann fluid substitution for rapid assessment of hydrogen and carbon dioxide saturations in clastic storage reservoirs.

Safe subsurface storage of carbon dioxide and hydrogen will likely be essential to decarbonising global energy systems. Such storage requires monitoring capable of detecting dynamic changes and unintended migration pathways; seismic methods are expected to form a key component. W...

Global City as an Emergent Category of Practice in Jakarta: Conjuncture, Capaciousness and Contentions

ABSTRACT In April 2024, the Indonesian government officially declared Jakarta a global city. Although scholars have noted that Jakarta's connectedness to the global system and the aspiration to transform Jakarta into a global city are not new, the lexicon was not yet substantivel...

Geographies of Inequalities: Towards Just Places

ABSTRACT In this intervention, I introduce the theme for the RGS‐IBG 2026 Annual Conference and argue that the complex geographies of inequalities are a key focus of the discipline and that the current moment requires urgent attention to be given to addressing such issues. Approa...

Vulnerable groups’ engagement with interventions to mitigate the health impacts of exposure to extreme temperature events: a qualitative systematic review

Abstract Extreme temperature events are becoming more frequent. Such events are defined as unusually hot weather persisting for at least two consecutive days (heatwave) or unusually cold weather persisting for at least two consecutive days (cold wave) within the context of geogra...

‘Even if you are guilty, you’re still a human being’: the impact of stigma on dignity and quality of healthcare from the perspective of people detained in police custody in England

Abstract Background The aim of this paper is to explore harms to health and dignity generated through stigma from the perspective of people detained in police custody, a neglected population in healthcare research. We adopt an original theoretical approach, bringing together a hu...

Representation of Long‐Term Observed UK Winter Precipitation Trends and Variability in UKCP18 Global Climate Models

ABSTRACT Evaluating the representation of observed precipitation trends in historical climate model simulations is challenging due to the combined effects of dynamical and thermodynamic changes and the strong influence of natural variability. Here, we assess the representation of...

Promising security, delivering dependency: the material constraints of EU semiconductor collective securitisation

This article argues that the European Union’s collective securitisation of semiconductors reveals an overlooked constraint in securitisation theory: the structural mismatch between the ‘urgency’ logic of securitisation, and the multi-year timescales required to develop material c...