Newcastle University

Six weeks of isometric resistance training led to evidence of corticospinal but not reticulospinal adaptation in previously untrained adult males

Abstract The latest hypothesis regarding the source of enhanced neural activation from resistance training is the reticulospinal rather than the corticospinal tract, based on invasive animal and emerging human data. The present study employed a six-week isometric resistance train...

Digenic disease causing variants in a patient with severe nephrocalcinosis

Abstract Background Nephrocalcinosis and cystinuria are two distinct kidney disorders. Nephrocalcinosis is the abnormal, generalised deposition of calcium salts, primarily calcium phosphate or calcium oxalate, within the kidney's parenchyma, and has multiple causes including meta...

Digital learning to support recruitment into cancer clinical research nursing: evaluation of a national e-learning course

Clinical research nurses (CRNs) are essential to the safe delivery of cancer clinical trials and represent an important component of the specialist cancer nursing workforce. However, nursing students often have limited awareness of the role and may not recognise it as a potential...

Rehabilitation and management interventions for people with chronic musculoskeletal condition/s and mental distress: a systematic scoping review

Abstract Background Musculoskeletal (MSK) conditions and mental distress present significant challenges for rehabilitation services. Currently, mental and physical healthcare is often segregated despite growing recognition for integrative interventions. This review aimed to map o...

Dual effect of α-synuclein disease variants on condensate formation

Abstract α-synuclein is a pre-synaptic protein implicated in synucleinopathies including Parkinson’s disease, Parkinson’s disease dementia, and dementia with Lewy bodies, where it accumulates in intracellular aggregates termed Lewy bodies and Lewy neurites. Recent studies have re...

Membrane affinity difference between MinD monomer and dimer is not crucial for MinD gradient formation in Bacillus subtilis

Proteins can diffuse micrometers in seconds, yet bacterial cells are able to maintain stable protein gradients. The best studied bacterial protein gradient is the Min system of Escherichia coli. In rod-shaped bacteria the MinCD proteins prevent formation of minicells by inhibitin...

Coordinated control of heterogeneous grid-connected energy storage systems

In this paper, it is demonstrated how the coordinated control of heterogeneous grid-connected Energy Storage Systems (ESSs) can result in increased profits compared to operating the ESSs independently when participating in the UK frequency market. A heterogeneous set of ESSs is m...

Identifying conflict hotspots in Papua through integrated graph theory and clustering analysis

Abstract Conflict in Papua has long attracted academic and policy attention, yet most studies remain descriptive and qualitative, leaving gaps in predictive capacity and quantitative validation. This study addresses these limitations by applying an integrated computational framew...

What comes after settler colonialism? Land, home and decolonizations in Palestine/Israel

Following the idea that “decolonization is not a metaphor” ( Tuck and Yang 2012 ), this article examines how de-(settler)colonization might look in the case of Palestine/Israel. We consider settler colonialism as an organized form of “violent dwelling”: a mechanism of monopoly on...

Implementation of health independent Domestic Violence Advisors (hIDVA): a qualitative study in five NHS Trusts

Abstract Background People who experience domestic abuse report increased use of healthcare services, compared to those not experiencing abuse. Independent Domestic Violence Advisors (IDVA) are evidence-based programmes that provide emotional and practical support to people exper...

Histological manifestations of vitamin A toxicity in the liver

Vitamin A (VitA) is a fat-soluble micronutrient involved in various physiological processes. Its sustained intake exceeding physiological needs leads to increased hepatic accumulation warranting careful monitoring for potential health implications. Despite being widely studied in...

Cumulative surgeon volume is associated with improved outcomes following hip arthroscopy: A national registry study

Abstract Purpose This study assessed the association between (1) annual and (2) cumulative surgeon volume and patient‐reported outcome measures (PROMS) after hip arthroscopic surgery for femoroacetabular impingement syndrome (FAIS) using data from the UK Nonarthroplasty hip regis...

Integrating human linguistic insights into AI: theory-driven representation for multilingual text-to-speech

This paper explores the integration of human linguistic insights into multilingual text-to-speech (TTS) systems by evaluating the Featurally Underspecified Lexicon (FUL) as a theory-driven input representation. Unlike data-intensive end-to end models, FUL offers a compact, interp...

What works, for whom, and under what circumstances for recipients of training in opportunistic behaviour change conversations: A mixed methods realist evaluation protocol

Abstract Background ‘Making Every Contact Count’ (MECC) is a person-centred initiative that enables service providers across settings to support behaviour change through conversations about health and wellbeing. MECC has been widely implemented across the UK and internationally,...

Diet and physical activity behaviours among people with insomnia symptoms: a cross-sectional survey to understand treatment needs and acceptability

Background High adherence to a Mediterranean diet and regular moderate-intensity physical activity (≥5 days/week, ≥30 minutes/day) reduce the risk of insomnia symptom onset and maintenance, yet engagement in these behaviours among adults with insomnia symptoms and the acceptabili...

The diagnosis and management of primary mediastinal B‐cell lymphoma: A British Society for Haematology guideline

Summary Primary mediastinal B‐cell lymphoma (PMBCL) is a distinct clinicopathological entity within the spectrum of aggressive B‐cell lymphomas, characterised by unique clinical, immunophenotypic and molecular features. Since publication of the 2019 British Society for Haematolog...

Aesthetic persuasion in theater-based interventions: Exploring persuasive capacities of theater as a mode of management learning and education

The article provides a framework for theorizing aesthetic persuasion in theater-based interventions as a mode of management learning and education. Taking an analytical look at the use of dramatic and postdramatic theater in critical management education, we apply the notion of a...

P1.204. Comparison of Freka and MIC Feeding Jejunostomy Complications After Ivor Lewis Esophagectomy

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – early outcomes and complications Background Feeding jejunostomy is frequently used as a nutritional adjunct following esophagectomy. Its routine placement remains debated, partially due to concerns regard...

P1.125. Challenging a Histology-Led Paradigm: Comparable Real-World Survival After Definitive Non-Surgical Treatment in Oesophageal Adenocarcinoma and Squamous Cell Carcinoma

Abstract Topic Esophageal Cancer: Oncology/Radiation Therapy Background Histology is often treated as a surrogate for radiosensitivity in oesophageal cancer, sustaining the prevailing assumption that squamous cell carcinoma (SCC) benefits more from definitive chemoradiotherapy th...

Strategic roadmap for delivery of clinical trials in rare childhood central nervous system (CNS) tumours: a multi-stakeholder consensus

Abstract Rare paediatric central nervous system (CNS) tumours comprise a biologically-heterogeneous group of low-incidence diseases that present significant challenges to both therapeutic development and clinical research, limiting the availability of high-quality evidence to gui...