National University of Singapore

A Technology-Blended Exercise Intervention for Cognitive Risk Reduction and Brain Health in Middle-Aged and Older Adults with Type 2 Diabetes in Singapore

BACKGROUND: Type 2 diabetes mellitus (T2DM) is a major modifiable risk factor for accelerated brain ageing, cognitive decline, and dementia. However, sustainable lifestyle interventions targeting cognitive health in at-risk older adult populations remain limited. This mixed-metho...

Wake-Up Call from the Past Investments

Asset impairment accounting requires firms to reassess their existing assets-in-place, namely, the outcomes of past investments, which enriches the information environment within the firm. We investigate whether this reassessment influences corporate investment strategies for lon...

Trinity Antennas: flexible active radio frequency systems with intrinsic heat spreading

Conformal, high-density, and high-power integration for radio frequency systems is critical to future wireless communications. Alumina ceramic offers significant potential owing to its ultra-low dielectric loss tangent. However, wireless systems that exploit alumina’s thermal adv...

Lighting up Metal Nanoclusters as Promising Molecular Emitters

Atomically precise metal nanoclusters (NCs) have emerged as promising optical materials in recent years. At the transition size between metal atoms and plasmonic metal nanoparticles, metal NCs exhibit elusive mechanisms underlying their photoluminescence (PL) properties. This fun...

Autonomous intranasal delivery systems for central nervous system therapeutics

Intranasal delivery provides a rapid, non-invasive route to the central nervous system, bypassing the blood-brain barrier and first-pass metabolism. However, its therapeutic potential remains constrained by the nasal cavity's complex anatomy, the restricted surface area and perme...

Vision-Based Counting of Horticultural Seeds Using ViT-UNet Density Regression for Post-Harvest Quality Assessment

Reliable counting of horticultural seeds is important for seed grading, batch consistency assessment, packaging, sowing-rate control, and post-harvest quality evaluation. Manual counting is labor-intensive, whereas conventional image-processing methods can be sensitive to seed ad...

Physics‐Informed Neural Networks for Flexoelectric Boundary Value Problems: A Reformulated Architecture for High‐ and Mixed‐Order Electromechanically Coupled Systems

ABSTRACT Flexoelectricity denotes a universal electromechanical coupling in dielectric materials, whereby strain gradients break local inversion symmetry and induce electric polarization. The resulting boundary value problem (BVP) is governed by a coupled multi‐physics system of...

Prognostic Stratification of Brain Metastases from Nonanaplastic Follicular Cell–Derived Thyroid Carcinoma: Results of an International Multicenter Retrospective Study

Background: Brain metastases (BMs) from nonanaplastic follicular cell–derived thyroid carcinoma (hereinafter referred to as non-ATC) are rare and not well characterized, with limited evidence guiding treatment and prognostic stratification. We aimed to describe clinical features,...

Making decisions about hormone replacement therapy for transgender and gender diverse youth in clinical settings in Singapore: a qualitative study

Objective: The objective of this study is to explore how clinical decision-making regarding hormone replacement therapy (HRT) for transgender and gender diverse (TGD) youth takes shape within clinical encounters involving healthcare providers, TGD youth, and their parents.Methods...

Menopausal arthralgia and longitudinal changes in sex hormones and climacteric symptoms

Musculoskeletal discomfort (menopausal arthralgia) is the most prevalent and debilitating complaint during the menopausal transition. Despite its high prevalence, menopausal arthralgia has historically been overlooked, and establishing a direct association with menopause remains...

Understanding the needs and frustrations in adolescent idiopathic scoliosis: a qualitative interview study

Abstract Background Scoliosis is a common term used for a group of conditions that involve abnormal curvature and rotation of the spine, thorax, and trunk. If untreated, scoliosis may lead to severe trunk deformities, which consequently limit physical function, exercise capacity,...

Antibiotic development and a path to access in India

Antibiotic development has historically been concentrated in high-income countries. We discuss how India is emerging as an important centre for antimicrobial development, and the implications for global health and equity of access to life-saving therapies. India is emerging as an...

Implant Migration and Dislocation Following Lumbar Total Disc Replacement: A Scoping Review of Risk Factors, Treatment, and Results

<sec><title>Background</title> Lumbar total disc replacement (TDR) is an alternative to interbody fusion for treating symptomatic degenerative disc disease. This approach involves replacing deteriorated lumbar discs with a prosthetic device to alleviate pain and maintain spinal m...

Designing transformative sustainability education: a mixed methods study exploring the values and perspectives of medical students

Abstract Introduction Education for Sustainable Healthcare (ESH) is a novel area of medical education and high-quality evidence to guide effective learning approaches is yet to be established. This study investigates the design of ESH in undergraduate medicine through the lenses...